Hotels in 77221 - Houston TX

Only hotels in 77221 zip code are listed below. Search for cheap and discount hotel rates in Houston, TX for your upcoming leisure or conference / group travel. We list the best 77221 hotels and motels so you can review the Houston hotel list below to find the perfect lodging. Hotels in Harris county and area code 713 are also listed.

77221 Hotels, Motels & Accommodations

Cliù Luxury Boutique Condo Hotel
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
3144 Southmore Blvd. Unit 10, Houston, TX 77004 +1-888-389-4121 ~1.13 miles northwest of 77221
  • 4 star Downtown property
  • 2 floors in hotel
More Photos
From$100
Average 3.0 /5 Review Score Call BookMore Details
Extended Stay America Suites Houston Med Ctr Greenway Plaza - Houston
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
2330 Southwest Frwy, Houston, TX 77098 +1-888-675-2083 ~1.17 miles west of 77221
  • Inexpensive Downtown property
  • Free comp. breakfast
More Photos
From$61
Average 3.0 /5 Recent Reviews Call BookMore Details
Summit Inn - Houston Medical Center : 3138 Old Spanish Trail
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
3138 Old Spanish Trail, Houston, TX 77054 +1-800-716-8490 ~1.37 miles west of 77221
  • Cheap property
  • Check in time: 11:00
More Photos
From$60
Average 3.0 /5 Read Reviews Call BookMore Details
Mainstay Suites Medical Center / Reliant Park
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
3134 Old Spanish Trail, Houston, TX 77054 +1-800-805-5223 ~1.41 miles west of 77221
  • Low priced Convention Center property
  • Check in: 11:00
More Photos
From$60
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Hiton University of Houston : 4800 Calhoun Rd.
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
4800 Calhoun Rd., Houston, TX 77004 +1-888-965-1860 ~1.54 miles northeast of 77221
  • Four star Downtown hotel
  • 12 suites in hotel
More Photos
From$125
Average 3.0 /5 Latest Reviews Call BookMore Details
Americas Best Value Inn Medical Center Downtown
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
2419 Riverside Dr., Houston, TX 77004 +1-888-788-5576 ~1.65 miles northwest of 77221
  • Two star property
  • 40 sleeping rooms in hotel
More Photos
From$60
Very Good 4.0 /5 Review Score Call BookMore Details
Home2 Suites : 6840 Almeda Rd.
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
6840 Almeda Rd., Houston, TX 77030 +1-888-897-9207 ~1.82 miles west of 77221
  • 3-star Suburban hotel
  • Check-in: 3:00 PM
More Photos
From$99
Excellent 5.0 /5 Latest Reviews Call BookMore Details
Hilton Garden Inn - Houston
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
6840b Almeda Rd., Houston, TX 77030 +1-888-311-4278 ~1.82 miles west of 77221
  • Three Star Suburban hotel
  • 157 rooms in property
More Photos
From$109
Average 3.0 /5 Reviews Call BookMore Details
Hilton Garden : 6840 B Almeda Rd.
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
6840 B Almeda Rd., Houston, TX 77030 +1-888-469-4795 ~1.82 miles west of 77221
  • Affordable hotel
More Photos
From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
Medical District
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
2700 Old Spanish Trail, Houston, TX 77021 +1-888-734-9421 ~1.92 miles west of 77221
  • High end property
More Photos
From$75
Average 3.0 /5 Reviews Call BookMore Details
Sonder The Hampstead in Houston
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
1508 Blodgett, Houston, TX 77004 +1-888-841-5292 ~2.33 miles northwest of 77221
  • 3-star Downtown hotel
  • Check-in time: 4:00 PM
More Photos
From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Scott Inn Suites Downtown Houston
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
1933 Scott St., Houston, TX 77003 +1-888-455-5160 ~2.34 miles north of 77221
  • Affordable property
  • Check in time: 15:00
More Photos
From$90
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Best Way Inn Houston - Medical Center
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
3100 Holmes Rd., Houston, TX 77051 +1-888-965-8297 ~2.49 miles southwest of 77221
  • Economical hotel
  • Check in time: 13:00
More Photos
From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Extended Stay America Suites Houston Med Ctr Braeswood Bl - Houston
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
1301 Braeswood Blvd., Houston, TX 77030 +1-888-906-6358 ~2.52 miles west of 77221
  • Affordable Convention Center hotel
  • Check in: 3:00pm
More Photos
From$64
Average 3.0 /5 Hotel Reviews Call BookMore Details
Hotel Zaza Houston Museum District - Houston
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
5701 Main St., Houston, TX 77005 +1-888-749-6785 ~2.57 miles northwest of 77221
  • Expensive Downtown property
  • Access to gym on-site
More Photos
From$159
Very Good 4.5 /5 Hotel Reviews Call BookMore Details
Blossom Houston Medical Center - Houston
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
7114 Bertner Ave., Houston, TX 77030 +1-888-878-9982 ~2.68 miles west of 77221
  • Midscale hotel
  • Hotel has 230 rooms
More Photos
From$90
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Blossom Houston in Houston
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
7118 Bertner Ave., Houston, TX 77030 +1-888-389-4485 ~2.69 miles west of 77221
  • Four star Convention Center hotel
  • Check-in: 3:00PM
More Photos
From$125
Average 3.0 /5 Recent Reviews Call BookMore Details
Days Inn & Suites by Wyndham Downtown / University of Houston - Houston
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
6190 Gulf Freeway, Houston, TX 77023 +1-888-389-4121 ~2.73 miles east of 77221
  • Midscale Downtown property
  • Check in time: 2:00pm
More Photos
From$55
Average 3.0 /5 Latest Reviews Call BookMore Details
Lexington Hotel Houston Medical Center in Houston
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
1025 Swanson St., Houston, TX 77030 +1-888-675-2083 ~2.78 miles west of 77221
  • Low-priced Downtown property
  • Fitness / Gym is on-site
More Photos
From$60
Average 3.5 /5 Read Reviews Call BookMore Details
Hyatt Place Hyatt House Houston Medical Center in Houston
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
7329 Fannin St., Houston, TX 77030 +1-800-716-8490 ~2.79 miles west of 77221
  • Affordable Suburban property
  • Hotel has 14 floors
More Photos
From$99
Average 3.0 /5 Latest Reviews Call BookMore Details
Hyatt Place : 7329a Fannin St.
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
7329a Fannin St., Houston, TX 77030 +1-800-805-5223 ~2.79 miles west of 77221
  • 3-star hotel
More Photos
From$80
Average 3.0 /5 Review Score Call BookMore Details
Houston Marriott Medical Center/Museum District : 6580 Fannin St.
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
6580 Fannin St., Houston, TX 77030 +1-888-965-1860 ~2.80 miles west of 77221
  • 4-star Downtown property
  • Hotel has 22 suites
More Photos
From$75
Very Good 4.5 /5 Latest Reviews Call BookMore Details
The Westin Hou Medical Center
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
1709 Dryden Rd., Houston, TX 77030 +1-888-788-5576 ~2.81 miles west of 77221
  • Affordable hotel
  • Fitness center on property
More Photos
From$90
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Sonder at Mid Main
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
3550 Main St., Houston, TX 77002 +1-888-897-9207 ~2.87 miles northwest of 77221
  • Midscale Downtown property
  • Hotel has 4 floors
More Photos
From$75
Average 3.0 /5 Reviews Call BookMore Details
Hampton Inn & Suites Houston Medical Center Nrg Park
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
1715 Old Spanish Trail, Houston, TX 77054 +1-888-311-4278 ~2.92 miles west of 77221
  • 3-star Convention Center hotel
  • Check in time: 3:00PM
More Photos
From$69
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
SureStay Plus by Best Western Houston Medical Center
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
6700 Main St., Houston, TX 77030 +1-888-469-4795 ~2.94 miles west of 77221
  • 3 star Downtown property
  • Has environment-friendly policy Learn more
More Photos
From$57
Average 3.5 /5 Latest Reviews Call BookMore Details
InterContinental Houston, an IHG Hotel : 6750 Main St.
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
6750 Main St., Houston, TX 77030 +1-888-734-9421 ~2.98 miles west of 77221
  • 4 star Downtown property
  • Check in time: 15:00
More Photos
From$75
Average 3.0 /5 Reviews Call BookMore Details
Doubletree by Hilton Houston Medical Center Hotel & Suites
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
6800 Main St., Houston, TX 77030 +1-888-841-5292 ~3.01 miles west of 77221
  • Three Star Downtown property
  • 10 floors in hotel
More Photos
From$80
Average 3.0 /5 Guest Reviews Call BookMore Details
Extended Stay America - Houston - Med Ctr-NRG Park-Fannin
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
7979 Fannin, Houston, TX 77054 +1-888-455-5160 ~3.02 miles west of 77221
  • Cheap Convention Center hotel
  • Check in: 3pm
More Photos
From$49
Poor 2.5 /5 Latest Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites Houston-Downtown Conv Ctr, an
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
1810 Bell St., Houston, TX 77003 +1-888-965-8297 ~3.11 miles north of 77221
  • Affordable Downtown hotel
  • Fitness center on property
More Photos
From$108
Very Good 4.0 /5 Review Score Call BookMore Details
Springhill Suites Marriott Medical Center Nrg Park in Houston
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
1400 Old Spanish Trail, Houston, TX 77054 +1-888-906-6358 ~3.33 miles west of 77221
  • 3 star Downtown property
  • Check-in time: 3.00 pm
More Photos
From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
Whyhotel Houston Downtown : 1515 Austin St.
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
1515 Austin St., Houston, TX 77002 +1-888-749-6785 ~3.33 miles north of 77221
  • Affordable property
  • Check in: 15:00
More Photos
From$90
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Athens Hotel Suites in Houston
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
1308 Clay St., Houston, TX 77002 +1-888-878-9982 ~3.39 miles north of 77221
  • 3-star Downtown hotel
  • Free breakfast available
More Photos
From$89
Average 3.0 /5 Hotel Reviews Call BookMore Details
Hilton Americas Houston : 1600 Lamar St.
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
1600 Lamar St., Houston, TX 77010 +1-888-389-4485 ~3.41 miles north of 77221
  • High end Downtown property
  • 66 suites in hotel
More Photos
From$101
Very Good 4.5 /5 Reviews Call BookMore Details
La Colombe D Or Hotel : 3410 Montrose Blvd.
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
3410 Montrose Blvd., Houston, TX 77006 +1-888-389-4121 ~3.41 miles northwest of 77221
  • Mid-scale property
  • Check in time: 16:00
More Photos
From$90
Average 3.0 /5 Read Reviews Call BookMore Details
Hotel Saint Augustine
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
4110 Loretto Dr., Houston, TX 77006 +1-888-675-2083 ~3.41 miles northwest of 77221
  • Four-star Downtown hotel
  • 2 floors in hotel
More Photos
From$250
Average 3.0 /5 Guest Reviews Call BookMore Details
Embassy Suites Houston Downtown in Houston
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
1515 Dallas, Houston, TX 77010 +1-800-716-8490 ~3.43 miles north of 77221
  • Affordable Downtown hotel
  • Hotel has 262 suites
More Photos
From$135
Very Good 4.0 /5 Reviews Call BookMore Details
Sonder Midtown : 306 Mcgowen St.
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
306 Mcgowen St., Houston, TX 77006 +1-800-805-5223 ~3.44 miles northwest of 77221
  • 3 star Downtown property
  • Hotel has 11 suites
More Photos
From$75
Average 3.0 /5 Recent Reviews Call BookMore Details
Holiday Inn Houston Downtown, an IHG Hotel
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
1616 Main St., Houston, TX 77002 +1-888-965-1860 ~3.46 miles north of 77221
  • Three Star Downtown property
  • Hotel has 213 rooms
More Photos
From$79
Poor 2.0 /5 Review Score Call BookMore Details
Marriott Marquis Houston : 1777 Walker St.
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
1777 Walker St., Houston, TX 77010 +1-888-788-5576 ~3.47 miles north of 77221
  • Four star property
  • Hotel has 29 floors
More Photos
From$375
Very Good 4.0 /5 Reviews Call BookMore Details
Courtyard by Marriott Houston Medical Center/NRG Park
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
Houston Medical Center 7702 Main St., Houston, TX 77030 +1-888-897-9207 ~3.48 miles west of 77221
  • Three Star Suburban property
  • 8 floors in hotel
More Photos
From$69
Very Good 4.0 /5 Review Score Call BookMore Details
Sonder Lofts at Ballpark - Houston
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
610 St. Emanuel St. Houston Tx 77003, Houston, TX 77003 +1-888-311-4278 ~3.48 miles north of 77221
  • 3 star Downtown hotel
  • 22 sleeping rooms in hotel
More Photos
From$100
Average 3.0 /5 Recent Reviews Call BookMore Details
The Reside in Houston
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
7755 South Main St., Houston, TX 77054 +1-888-469-4795 ~3.51 miles west of 77221
  • Mid-scale Downtown property
  • Gym is available on property
More Photos
From$55
Very Good 4.0 /5 Review Score Call BookMore Details
Holiday Inn Houston S - Nrg Area - Medical Center, an IHG Hotel
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
8111 Kirby Dr., Houston, TX 77054 +1-888-734-9421 ~3.51 miles west of 77221
  • Affordable Suburban hotel
  • 6 suites in property
More Photos
From$126
Average 3.5 /5 Recent Reviews Call BookMore Details
Four Seasons Hotel Houston in Houston
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
1300 Lamar St., Houston, TX 77010 +1-888-841-5292 ~3.51 miles north of 77221
  • Luxury 5-star Downtown property
  • 12 meeting rooms in hotel
More Photos
From$275
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Extended Stay America Suites Houston Med Ctr NRG Park Kirby - Houston
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
1303 La Concha Ln, Houston, TX 77054 +1-888-455-5160 ~3.52 miles west of 77221
  • Economy Convention Center property
  • Hotel has 3 floors
More Photos
From$41
Average 3.0 /5 Latest Reviews Call BookMore Details
Courtyard by Marriott Houston Medical Center/NRG Park in Houston
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
7702 Main St., Houston, TX 77030 +1-888-965-8297 ~3.55 miles west of 77221
  • 3-star Downtown property
  • Hotel has a green policy See more
More Photos
From$80
Average 3.0 /5 Latest Reviews Call BookMore Details
Bayou City Event Center - Houston
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
9401 Knight Rd., Houston, TX 77045 +1-888-906-6358 ~3.56 miles southwest of 77221
  • Two-star hotel
More Photos
From$60
Average 3.0 /5 Review Score Call BookMore Details
Residence Inn Houston Medical Center / Nrg Park : 7807 Kirby Dr.
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
7807 Kirby Dr., Houston, TX 77030 +1-888-749-6785 ~3.56 miles west of 77221
  • Three Star Downtown hotel
  • Access to gym on-site
More Photos
From$109
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Moody Manor
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
7706 Main St., Houston, TX 77030 +1-888-878-9982 ~3.58 miles west of 77221
  • Three Star Downtown property
  • 2 floors in property
More Photos
From$69
Average 3.5 /5 Guest Reviews Call BookMore Details
Back to Top