Star Rating
Hotel Name
Price Range (USD) to
Amenities
+ More

77221 Hotels & Accommodations

CliĆ¹ Luxury Boutique Condo Hotel : 3144 Southmore Blvd. Unit 10
+1-888-389-4121
3144 Southmore Blvd. Unit 10, Houston, TX 77004 ~1.13 miles northwest of 77221
  • Four-star Downtown property
  • Check-in: 4:00pm CST
From$100
Average 3.0 /5 Guest Reviews Call BookMore Details
Tired of clicking around? Talk to an expert Hotel Planner: (855) 276-7561 or say...
alexa hotel planner skill"Alexa, ask Hotel Planner to make a new reservation in 77221" Get Alexa Skill →
Extended Stay America Suites Houston Med Ctr Greenway Plaza in Houston
+1-888-675-2083
2330 Southwest Frwy, Houston, TX 77098 ~1.17 miles west of 77221
  • Cheap Downtown property
  • 122 rooms in property
From$61
Average 3.0 /5 Read Reviews Call BookMore Details
Summit Inn - Houston Medical Center
+1-800-716-8490
3138 Old Spanish Trail, Houston, TX 77054 ~1.37 miles west of 77221
  • 2 star hotel
  • 33 sleeping rooms in hotel
From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Mainstay Suites Medical Center / Reliant Park
+1-800-805-5223
3134 Old Spanish Trail, Houston, TX 77054 ~1.41 miles west of 77221
  • Low Cost Convention Center property
  • Check-in time: 11:00
From$60
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Hiton University of Houston : 4800 Calhoun Rd.
+1-888-965-1860
4800 Calhoun Rd., Houston, TX 77004 ~1.54 miles northeast of 77221
  • 4 star Downtown property
  • Free breakfast
From$125
Average 3.0 /5 Guest Reviews Call BookMore Details
Americas Best Value Inn Medical Center Downtown - Houston
+1-888-788-5576
2419 Riverside Dr., Houston, TX 77004 ~1.65 miles northwest of 77221
  • Economical property
  • Check-in: 15:00
From$60
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Home2 Suites
+1-888-897-9207
6840 Almeda Rd., Houston, TX 77030 ~1.82 miles west of 77221
  • Three Star Suburban property
  • Gym / Fitness Center Available
From$99
Excellent 5.0 /5 Reviews Call BookMore Details
Hilton Garden Inn in Houston
+1-888-311-4278
6840b Almeda Rd., Houston, TX 77030 ~1.82 miles west of 77221
  • 3 star Suburban hotel
  • Gym is available on property
From$109
Average 3.0 /5 Read Reviews Call BookMore Details
Hilton Garden in Houston
+1-888-469-4795
6840 B Almeda Rd., Houston, TX 77030 ~1.82 miles west of 77221
  • 3 star property
From$80
Average 3.0 /5 Reviews Call BookMore Details
Medical District in Houston
+1-888-734-9421
2700 Old Spanish Trail, Houston, TX 77021 ~1.92 miles west of 77221
  • High end hotel
From$75
Average 3.0 /5 Reviews Call BookMore Details
Sonder The Hampstead
+1-888-841-5292
1508 Blodgett, Houston, TX 77004 ~2.33 miles northwest of 77221
  • 3 star Downtown hotel
  • Hotel has 4 floors
From$80
Average 3.0 /5 Guest Reviews Call BookMore Details
Scott Inn Suites Downtown Houston
+1-888-455-5160
1933 Scott St., Houston, TX 77003 ~2.34 miles north of 77221
  • 3 star property
  • 2 floors in hotel
From$90
Very Good 4.0 /5 Review Score Call BookMore Details
Best Way Inn Houston - Medical Center - Houston
+1-888-965-8297
3100 Holmes Rd., Houston, TX 77051 ~2.49 miles southwest of 77221
  • Low priced hotel
  • Hotel has 42 rooms
From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Extended Stay America Suites Houston Med Ctr Braeswood Bl
+1-888-906-6358
1301 Braeswood Blvd., Houston, TX 77030 ~2.52 miles west of 77221
  • Mid-scale Convention Center hotel
  • 4 suites in property
From$64
Average 3.0 /5 Guest Reviews Call BookMore Details
Hotel Zaza Houston Museum District
+1-888-749-6785
5701 Main St., Houston, TX 77005 ~2.57 miles northwest of 77221
  • High-end Downtown property
  • 15 conference rooms in property
From$159
Very Good 4.5 /5 Recent Reviews Call BookMore Details
Need some questions answered? Talk to an expert Hotel Planner: (855) 276-7561 or say...
alexa hotel planner skill"Alexa, ask Hotel Planner to make a new reservation in 77221" Get Alexa Skill →
Blossom Houston Medical Center : 7114 Bertner Ave.
+1-888-878-9982
7114 Bertner Ave., Houston, TX 77030 ~2.68 miles west of 77221
  • Affordable hotel
  • 230 sleeping rooms in hotel
From$90
Very Good 4.0 /5 Review Score Call BookMore Details
Blossom Houston : 7118 Bertner Ave.
+1-888-389-4485
7118 Bertner Ave., Houston, TX 77030 ~2.69 miles west of 77221
  • Four star Convention Center property
  • Check-in: 3:00PM
From$125
Average 3.0 /5 Hotel Reviews Call BookMore Details
Days Inn & Suites by Wyndham Downtown / University of Houston - Houston
+1-888-389-4121
6190 Gulf Freeway, Houston, TX 77023 ~2.73 miles east of 77221
  • 3-star Downtown property
  • Fitness / Gym is on-site
From$55
Average 3.0 /5 Latest Reviews Call BookMore Details
Lexington Hotel Houston Medical Center
+1-888-675-2083
1025 Swanson St., Houston, TX 77030 ~2.78 miles west of 77221
  • Cheap Downtown hotel
  • Access to gym on-site
From$60
Average 3.5 /5 Latest Reviews Call BookMore Details
Hyatt Place in Houston
+1-800-716-8490
7329a Fannin St., Houston, TX 77030 ~2.79 miles west of 77221
  • 3-star hotel
From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Hyatt Place Hyatt House Houston Medical Center
+1-800-805-5223
7329 Fannin St., Houston, TX 77030 ~2.79 miles west of 77221
  • Affordable Suburban property
  • 3 meeting rooms in property
From$99
Average 3.0 /5 Recent Reviews Call BookMore Details
Houston Marriott Medical Center/Museum District
+1-888-965-1860
6580 Fannin St., Houston, TX 77030 ~2.80 miles west of 77221
  • 4 star Downtown property
  • 14 conference rooms in property
From$75
Very Good 4.5 /5 Latest Reviews Call BookMore Details
The Westin Hou Medical Center - Houston
+1-888-788-5576
1709 Dryden Rd., Houston, TX 77030 ~2.81 miles west of 77221
  • Mid-scale hotel
  • Gym is available on property
From$90
Very Good 4.0 /5 Review Score Call BookMore Details
Sonder at Mid Main
+1-888-897-9207
3550 Main St., Houston, TX 77002 ~2.87 miles northwest of 77221
  • Mid-scale Downtown hotel
  • Hotel has 26 rooms
From$75
Average 3.0 /5 Recent Reviews Call BookMore Details
Hampton Inn & Suites Houston Medical Center Nrg Park in Houston
+1-888-311-4278
1715 Old Spanish Trail, Houston, TX 77054 ~2.92 miles west of 77221
  • Three Star Convention Center hotel
  • 5 floors in hotel
From$69
Very Good 4.0 /5 Review Score Call BookMore Details
Houston Medical Center Hotel - Houston
+1-888-469-4795
6700 Main St., Houston, TX 77030 ~2.94 miles west of 77221
  • Mid-scale Downtown property
  • 2 conference rooms in property
From$115
Average 3.5 /5 Read Reviews Call BookMore Details
InterContinental Houston, an IHG Hotel - Houston
+1-888-734-9421
6750 Main St., Houston, TX 77030 ~2.98 miles west of 77221
  • Expensive Downtown hotel
  • 354 rooms in hotel
From$75
Average 3.0 /5 Hotel Reviews Call BookMore Details
Doubletree by Hilton Houston Medical Center Hotel & Suites - Houston
+1-888-841-5292
6800 Main St., Houston, TX 77030 ~3.01 miles west of 77221
  • Mid-scale Downtown property
  • Check-in time: 3:00PM
From$80
Average 3.0 /5 Read Reviews Call BookMore Details
Extended Stay America - Houston - Med Ctr-NRG Park-Fannin
+1-888-455-5160
7979 Fannin, Houston, TX 77054 ~3.02 miles west of 77221
  • 2 star Convention Center hotel
  • 153 sleeping rooms in hotel
Holiday Inn Express Hotel & Suites Houston-Downtown Conv Ctr, an
+1-888-965-8297
1810 Bell St., Houston, TX 77003 ~3.11 miles north of 77221
  • Affordable Downtown property
  • 4 floors in property
From$108
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Springhill Suites Marriott Medical Center Nrg Park : 1400 Old Spanish Trail
+1-888-906-6358
1400 Old Spanish Trail, Houston, TX 77054 ~3.33 miles west of 77221
  • 3-star Downtown hotel
  • Hotel has 190 suites
From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
Whyhotel Houston Downtown : 1515 Austin St.
+1-888-749-6785
1515 Austin St., Houston, TX 77002 ~3.33 miles north of 77221
  • 3-star property
  • Hotel has 103 rooms
From$90
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Athens Hotel Suites
+1-888-878-9982
1308 Clay St., Houston, TX 77002 ~3.39 miles north of 77221
  • Midscale Downtown property
  • Hotel has a green policy See policy
From$89
Average 3.0 /5 Read Reviews Call BookMore Details
La Colombe D Or Hotel
+1-888-389-4485
3410 Montrose Blvd., Houston, TX 77006 ~3.41 miles northwest of 77221
  • Mid-scale property
  • Check in time: 16:00
From$90
Average 3.0 /5 Hotel Reviews Call BookMore Details
Hilton Americas Houston
+1-888-389-4121
1600 Lamar St., Houston, TX 77010 ~3.41 miles north of 77221
  • 4-star Downtown hotel
  • Check in: 3:00 PM
From$101
Very Good 4.5 /5 Recent Reviews Call BookMore Details
Hotel Saint Augustine - Houston
+1-888-675-2083
4110 Loretto Dr., Houston, TX 77006 ~3.41 miles northwest of 77221
  • 4-star Downtown property
  • Hotel has 71 rooms
From$250
Average 3.0 /5 Recent Reviews Call BookMore Details
Embassy Suites Houston Downtown
+1-800-716-8490
1515 Dallas, Houston, TX 77010 ~3.43 miles north of 77221
  • Affordable Downtown property
  • 5 conference rooms in property
From$135
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Sonder Midtown - Houston
+1-800-805-5223
306 Mcgowen St., Houston, TX 77006 ~3.44 miles northwest of 77221
  • 3-star Downtown hotel
  • Hotel has 6 floors
From$75
Average 3.0 /5 Latest Reviews Call BookMore Details
Holiday Inn Houston Downtown, an IHG Hotel : 1616 Main St.
+1-888-965-1860
1616 Main St., Houston, TX 77002 ~3.46 miles north of 77221
  • 3-star Downtown hotel
  • Hotel has 16 floors
Marriott Marquis Houston : 1777 Walker St.
+1-888-788-5576
1777 Walker St., Houston, TX 77010 ~3.47 miles north of 77221
  • 4 star hotel
  • Hotel has 76 meeting rooms
From$375
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Courtyard by Marriott Houston Medical Center/NRG Park in Houston
+1-888-897-9207
Houston Medical Center 7702 Main St., Houston, TX 77030 ~3.48 miles west of 77221
  • Mid-scale Suburban property
  • 8 floors in property
From$69
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Sonder Lofts at Ballpark in Houston
+1-888-311-4278
610 St. Emanuel St. Houston Tx 77003, Houston, TX 77003 ~3.48 miles north of 77221
  • Three Star Downtown property
  • 22 rooms in property
From$100
Average 3.0 /5 Reviews Call BookMore Details
The Reside in Houston
+1-888-469-4795
7755 South Main St., Houston, TX 77054 ~3.51 miles west of 77221
  • Mid-scale Downtown property
  • 36 suites in hotel
From$55
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Holiday Inn Houston S - Nrg Area - Medical Center, an IHG Hotel - Houston
+1-888-734-9421
8111 Kirby Dr., Houston, TX 77054 ~3.51 miles west of 77221
  • 3 star Suburban property
  • 238 rooms in property
From$126
Average 3.5 /5 Recent Reviews Call BookMore Details
Four Seasons Hotel Houston
+1-888-841-5292
1300 Lamar St., Houston, TX 77010 ~3.51 miles north of 77221
  • Luxury 5-star Downtown property
  • Hotel has 404 rooms
From$275
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Extended Stay America Suites Houston Med Ctr NRG Park Kirby
+1-888-455-5160
1303 La Concha Ln, Houston, TX 77054 ~3.52 miles west of 77221
  • 2 star Convention Center property
  • Hotel has 84 rooms
From$41
Average 3.0 /5 Latest Reviews Call BookMore Details
Courtyard Houston Medical Center / Nrg Park
+1-888-965-8297
7702 Main St., Houston, TX 77030 ~3.55 miles west of 77221
  • Affordable Downtown hotel
  • Hotel has 197 rooms
From$80
Average 3.0 /5 Latest Reviews Call BookMore Details
Bayou City Event Center in Houston
+1-888-906-6358
9401 Knight Rd., Houston, TX 77045 ~3.56 miles southwest of 77221
  • Cheap hotel
From$60
Average 3.0 /5 Reviews Call BookMore Details
Residence Inn Houston Medical Center / Nrg Park : 7807 Kirby Dr.
+1-888-749-6785
7807 Kirby Dr., Houston, TX 77030 ~3.56 miles west of 77221
  • Three Star Downtown property
  • Free breakfast available
From$109
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Moody Manor - Houston
+1-888-878-9982
7706 Main St., Houston, TX 77030 ~3.58 miles west of 77221
  • 3-star Downtown property
  • Check-in: 3:00pm
From$69
Average 3.5 /5 Read Reviews Call BookMore Details

Next: Show All Available 77221 Hotels with Pricing

Graph: Upcoming 20 Days of Houston Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Houston, TX discounts available. The chart reflects the cheapest Houston hotel for each day and each star rating category.

FAQs about hotels near 77221

What are the most favored hotels near 77221?

Home2 Suites, Hotel Zaza Houston Museum District and Houston Marriott Medical Center are the best rated hotels based on customer reviews in the last 365 days.

What are the most luxurious hotels near 77221?

Four Seasons Hotel Houston, CliĆ¹ Luxury Boutique Condo Hotel and Hiton University of Houston are the top 3 luxury hotels near 77221.

What hotels are closest to the area of 77221?

CliĆ¹ Luxury Boutique Condo Hotel, Extended Stay America Suites Houston Med Ctr Greenway Plaza, and Summit Inn - Houston Medical Center are the properties closest to 77221.

How much does a cheap hotel near 77221 cost per night?

In the last year, a 2 star hotel near 77221 can be as cheap as $63.37 per night. (based on HotelPlanner prices)

How much does a 3 star hotel near 77221 cost per night?

In the last year, the average 3 star hotel near 77221 has been $85.49 per night. (based on HotelPlanner prices)

How much does a 4-5 star hotel near 77221 cost?

In the last year, the average 4 star hotel near 77221 has been $111.54 per night. (based on HotelPlanner prices)

What are the best independent hotels near 77221?

Hotel Zaza Houston Museum District, Scott Inn Suites Downtown Houston and Blossom Houston Medical Center are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels near 77221?

Houston Marriott Medical Center, The Westin Hou Medical Center and Marriott Marquis Houston are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best IHG hotels near 77221?

Holiday Inn Express Hotel & Suites Houston-Downtown Conv Ctr, an, Holiday Inn Houston S - Nrg Area - Medical Center, an IHG Hotel and Holiday Inn Houston Downtown, an IHG Hotel are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

Back to Top