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77221 Hotels/Accommodations

Cliù Luxury Boutique Condo Hotel
+1-888-389-4121
3144 Southmore Blvd. Unit 10, Houston, TX 77004 ~1.13 miles northwest of 77221
  • High end Downtown property
  • 8 suites in hotel
From$100
Average 3.0 /5 Latest Reviews Call BookMore Details
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Extended Stay America Suites Houston Med Ctr Greenway Plaza
+1-888-675-2083
2330 Southwest Frwy, Houston, TX 77098 ~1.17 miles west of 77221
  • Economical Downtown property
  • 3 floors in property
From$61
Average 3.0 /5 Read Reviews Call BookMore Details
Summit Inn - Houston Medical Center
+1-800-716-8490
3138 Old Spanish Trail, Houston, TX 77054 ~1.37 miles west of 77221
  • Cheap property
  • 33 sleeping rooms in hotel
From$60
Average 3.0 /5 Review Score Call BookMore Details
Mainstay Suites Medical Center / Reliant Park - Houston
+1-800-805-5223
3134 Old Spanish Trail, Houston, TX 77054 ~1.41 miles west of 77221
  • Cheap Convention Center property
  • Fitness + Health Center
From$60
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Hilton University of Houston - Houston
+1-888-965-1860
4800 Calhoun Rd., Houston, TX 77004 ~1.54 miles northeast of 77221
  • 4 star Downtown property
  • 8 floors in hotel
From$125
Average 3.0 /5 Recent Reviews Call BookMore Details
Americas Best Value Inn Medical Center Downtown in Houston
+1-888-788-5576
2419 Riverside Dr., Houston, TX 77004 ~1.65 miles northwest of 77221
  • Cheap hotel
  • 2 floors in property
From$60
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Home2 Suites - Houston
+1-888-897-9207
6840 Almeda Rd., Houston, TX 77030 ~1.82 miles west of 77221
  • Three Star Suburban property
  • 143 suites in property
From$99
Excellent 5.0 /5 Guest Reviews Call BookMore Details
Hilton Garden Inn : 6840b Almeda Rd.
+1-888-311-4278
6840b Almeda Rd., Houston, TX 77030 ~1.82 miles west of 77221
  • 3 star Suburban hotel
  • 157 sleeping rooms in hotel
From$109
Average 3.0 /5 Latest Reviews Call BookMore Details
Hilton Garden
+1-888-469-4795
6840 B Almeda Rd., Houston, TX 77030 ~1.82 miles west of 77221
  • Three Star hotel
From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Medical District : 2700 Old Spanish Trail
+1-888-734-9421
2700 Old Spanish Trail, Houston, TX 77021 ~1.92 miles west of 77221
  • Four star hotel
From$75
Average 3.0 /5 Review Score Call BookMore Details
Sonder The Hampstead - Houston
+1-888-841-5292
1508 Blodgett, Houston, TX 77004 ~2.33 miles northwest of 77221
  • 3 star Downtown hotel
  • 36 rooms in property
From$80
Average 3.0 /5 Review Score Call BookMore Details
Scott Inn Suites Downtown Houston - Houston
+1-888-455-5160
1933 Scott St., Houston, TX 77003 ~2.34 miles north of 77221
  • Affordable hotel
  • 2 floors in hotel
From$90
Very Good 4.0 /5 Read Reviews Call BookMore Details
Best Way Inn Houston - Medical Center - Houston
+1-888-965-8297
3100 Holmes Rd., Houston, TX 77051 ~2.49 miles southwest of 77221
  • Cheap hotel
  • Check-in: 13:00
From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Extended Stay America Suites Houston Med Ctr Braeswood Bl in Houston
+1-888-906-6358
1301 Braeswood Blvd., Houston, TX 77030 ~2.52 miles west of 77221
  • 3-star Convention Center hotel
  • Gym / Fitness Center Available
From$64
Average 3.0 /5 Latest Reviews Call BookMore Details
Hotel Zaza Houston Museum District
+1-888-749-6785
5701 Main St., Houston, TX 77005 ~2.57 miles northwest of 77221
  • High-end Downtown property
  • Hotel has 315 rooms
From$159
Very Good 4.5 /5 Guest Reviews Call BookMore Details
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Blossom Houston Medical Center
+1-888-878-9982
7114 Bertner Ave., Houston, TX 77030 ~2.68 miles west of 77221
  • Three Star hotel
  • Hotel has 230 rooms
From$90
Very Good 4.0 /5 Reviews Call BookMore Details
Blossom Hotel Houston
+1-888-389-4485
7118 Bertner Ave., Houston, TX 77030 ~2.69 miles west of 77221
  • High-end Convention Center property
  • 12 conference rooms in property
From$99
Average 3.0 /5 Recent Reviews Call BookMore Details
Days Inn & Suites by Wyndham Downtown / University of Houston
+1-888-389-4121
6190 Gulf Freeway, Houston, TX 77023 ~2.73 miles east of 77221
  • Mid-scale Downtown hotel
  • Free breakfast available
From$55
Average 3.0 /5 Hotel Reviews Call BookMore Details
Lexington Hotel Houston Medical Center
+1-888-675-2083
1025 Swanson St., Houston, TX 77030 ~2.78 miles west of 77221
  • Economical Downtown property
  • Free breakfast
From$60
Average 3.5 /5 Hotel Reviews Call BookMore Details
Hyatt Place in Houston
+1-800-716-8490
7329a Fannin St., Houston, TX 77030 ~2.79 miles west of 77221
  • Three Star hotel
From$80
Average 3.0 /5 Review Score Call BookMore Details
Hyatt Place Hyatt House Houston Medical Center : 7329 Fannin St.
+1-800-805-5223
7329 Fannin St., Houston, TX 77030 ~2.79 miles west of 77221
  • 3 star Suburban property
  • 3 meeting rooms in property
From$99
Average 3.0 /5 Review Score Call BookMore Details
Houston Marriott Medical Center/Museum District - Houston
+1-888-965-1860
6580 Fannin St., Houston, TX 77030 ~2.80 miles west of 77221
  • Expensive Downtown hotel
  • 26 floors in property
From$75
Very Good 4.5 /5 Reviews Call BookMore Details
The Westin Hou Medical Center : 1709 Dryden Rd.
+1-888-788-5576
1709 Dryden Rd., Houston, TX 77030 ~2.81 miles west of 77221
  • 3-star hotel
  • Check-in time: 15:00
From$90
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Sonder at Mid Main - Houston
+1-888-897-9207
3550 Main St., Houston, TX 77002 ~2.87 miles northwest of 77221
  • 3-star Downtown hotel
  • Check-in time: 4:00 pm
From$75
Average 3.0 /5 Review Score Call BookMore Details
Hampton Inn & Suites Houston Medical Center Nrg Park in Houston
+1-888-311-4278
1715 Old Spanish Trail, Houston, TX 77054 ~2.92 miles west of 77221
  • Affordable Convention Center hotel
  • Hotel has 37 suites
From$69
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Houston Medical Center Hotel in Houston
+1-888-469-4795
6700 Main St., Houston, TX 77030 ~2.94 miles west of 77221
  • Three Star Downtown hotel
  • Comp. Breakfast
From$115
Average 3.5 /5 Latest Reviews Call BookMore Details
InterContinental Houston, an IHG Hotel : 6750 Main St.
+1-888-734-9421
6750 Main St., Houston, TX 77030 ~2.98 miles west of 77221
  • High end Downtown property
  • Has environment-friendly policy Read more
From$75
Average 3.0 /5 Guest Reviews Call BookMore Details
Doubletree by Hilton Houston Medical Center Hotel & Suites
+1-888-841-5292
6800 Main St., Houston, TX 77030 ~3.01 miles west of 77221
  • 3 star Downtown hotel
  • Fitness center on property
From$80
Average 3.0 /5 Latest Reviews Call BookMore Details
Extended Stay America - Houston - Med Ctr-NRG Park-Fannin : 7979 Fannin
+1-888-455-5160
7979 Fannin, Houston, TX 77054 ~3.02 miles west of 77221
  • Inexpensive Convention Center hotel
  • 3 floors in hotel
Holiday Inn Express Hotel & Suites Houston-Downtown Conv Ctr by I
+1-888-965-8297
1810 Bell St., Houston, TX 77003 ~3.11 miles north of 77221
  • 3 star Downtown property
  • Hotel has 22 suites
From$108
Very Good 4.0 /5 Guest Reviews Call BookMore Details
SpringHill Suites Houston Medical Center/NRG Park : 1400 Old Spanish Trail
+1-888-906-6358
1400 Old Spanish Trail, Houston, TX 77054 ~3.33 miles west of 77221
  • 3 star Downtown property
  • Gym is available on property
From$80
Average 3.0 /5 Reviews Call BookMore Details
Whyhotel Houston Downtown - Houston
+1-888-749-6785
1515 Austin St., Houston, TX 77002 ~3.33 miles north of 77221
  • 3-star hotel
  • Hotel has 103 rooms
From$90
Very Good 4.0 /5 Read Reviews Call BookMore Details
Athens Hotel Suites : 1308 Clay St.
+1-888-878-9982
1308 Clay St., Houston, TX 77002 ~3.39 miles north of 77221
  • Mid-scale Downtown property
  • 21 rooms in property
From$89
Average 3.0 /5 Hotel Reviews Call BookMore Details
La Colombe D Or Hotel - Houston
+1-888-389-4485
3410 Montrose Blvd., Houston, TX 77006 ~3.41 miles northwest of 77221
  • 3-star hotel
  • Hotel has 15 rooms
From$90
Average 3.0 /5 Review Score Call BookMore Details
Hilton Americas Houston - Houston
+1-888-389-4121
1600 Lamar St., Houston, TX 77010 ~3.41 miles north of 77221
  • High end Downtown hotel
  • 66 suites in property
From$101
Very Good 4.5 /5 Read Reviews Call BookMore Details
Hotel Saint Augustine
+1-888-675-2083
4110 Loretto Dr., Houston, TX 77006 ~3.41 miles northwest of 77221
  • Four star Downtown property
  • Check in: 3:00 PM
From$401
Average 3.0 /5 Reviews Call BookMore Details
Embassy Suites Houston Downtown - Houston
+1-800-716-8490
1515 Dallas, Houston, TX 77010 ~3.43 miles north of 77221
  • Mid-scale Downtown property
  • 262 rooms in property
From$135
Very Good 4.0 /5 Read Reviews Call BookMore Details
Sonder Midtown
+1-800-805-5223
306 Mcgowen St., Houston, TX 77006 ~3.44 miles northwest of 77221
  • 3 star Downtown hotel
  • 11 sleeping rooms in hotel
From$75
Average 3.0 /5 Recent Reviews Call BookMore Details
Holiday Inn Houston Downtown by IHG
+1-888-965-1860
1616 Main St., Houston, TX 77002 ~3.46 miles north of 77221
  • Affordable Downtown hotel
  • 213 rooms in hotel
Marriott Marquis Houston in Houston
+1-888-788-5576
1777 Walker St., Houston, TX 77010 ~3.47 miles north of 77221
  • High-end hotel
  • 29 floors in hotel
From$375
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Courtyard by Marriott Houston Medical Center/NRG Park
+1-888-897-9207
Houston Medical Center 7702 Main St., Houston, TX 77030 ~3.48 miles west of 77221
  • Mid-scale Suburban hotel
  • 3 meeting rooms in property
From$69
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Sonder Lofts at Ballpark
+1-888-311-4278
610 St. Emanuel St. Houston Tx 77003, Houston, TX 77003 ~3.48 miles north of 77221
  • Three Star Downtown property
  • Check-in: 4:00 PM
From$100
Average 3.0 /5 Read Reviews Call BookMore Details
The Reside
+1-888-469-4795
7755 South Main St., Houston, TX 77054 ~3.51 miles west of 77221
  • Affordable Downtown hotel
  • Hotel has 36 suites
From$55
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Holiday Inn Houston S - Nrg Area - Medical Center by IHG
+1-888-734-9421
8111 Kirby Dr., Houston, TX 77054 ~3.51 miles west of 77221
  • 3-star Suburban property
  • 238 rooms in hotel
From$126
Average 3.5 /5 Recent Reviews Call BookMore Details
Four Seasons Hotel Houston
+1-888-841-5292
1300 Lamar St., Houston, TX 77010 ~3.51 miles north of 77221
  • Luxurious 5-star Downtown property
  • 12 meeting rooms in property
From$275
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Extended Stay America Suites Houston Med Ctr NRG Park Kirby
+1-888-455-5160
1303 La Concha Ln, Houston, TX 77054 ~3.52 miles west of 77221
  • Two star Convention Center hotel
  • Free complimentary breakfast
From$41
Average 3.0 /5 Review Score Call BookMore Details
Courtyard Houston Medical Center / Nrg Park : 7702 Main St.
+1-888-965-8297
7702 Main St., Houston, TX 77030 ~3.55 miles west of 77221
  • Midscale Downtown property
  • Check-in: 03:00 PM
From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Bayou City Event Center
+1-888-906-6358
9401 Knight Rd., Houston, TX 77045 ~3.56 miles southwest of 77221
  • 2 star property
From$60
Average 3.0 /5 Reviews Call BookMore Details
Residence Inn Houston Medical Center / Nrg Park : 7807 Kirby Dr.
+1-888-749-6785
7807 Kirby Dr., Houston, TX 77030 ~3.56 miles west of 77221
  • 3-star Downtown hotel
  • 182 suites in hotel
From$109
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Moody Manor in Houston
+1-888-878-9982
7706 Main St., Houston, TX 77030 ~3.58 miles west of 77221
  • 3-star Downtown property
  • 197 suites in property
From$69
Average 3.5 /5 Guest Reviews Call BookMore Details

Next: Show All Available 77221 Hotels with Pricing

Graph: Upcoming 20 Days of Houston Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Houston, TX discounts available. The chart reflects the cheapest Houston hotel for each day and each star rating category.

FAQs about hotels near 77221

What are the most favored hotels near 77221?

Home2 Suites, Hotel Zaza Houston Museum District and Houston Marriott Medical Center are the best rated hotels based on customer reviews in the last 365 days.

What are the most luxurious hotels near 77221?

Four Seasons Hotel Houston, Cliù Luxury Boutique Condo Hotel and Hilton University of Houston are the top 3 luxury hotels near 77221.

What hotels are closest to the area of 77221?

Cliù Luxury Boutique Condo Hotel, Extended Stay America Suites Houston Med Ctr Greenway Plaza, and Summit Inn - Houston Medical Center are the properties closest to 77221.

How much does a cheap hotel near 77221 cost per night?

In the last year, a 2 star hotel near 77221 can be as cheap as $63.37 per night. (based on HotelPlanner prices)

How much does a 3 star hotel near 77221 cost per night?

In the last year, the average 3 star hotel near 77221 has been $85.49 per night. (based on HotelPlanner prices)

How much does a 4-5 star hotel near 77221 cost?

In the last year, the average 4 star hotel near 77221 has been $111.54 per night. (based on HotelPlanner prices)

What are the best independent hotels near 77221?

Hotel Zaza Houston Museum District, Scott Inn Suites Downtown Houston and Blossom Houston Medical Center are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels near 77221?

Houston Marriott Medical Center, The Westin Hou Medical Center and Marriott Marquis Houston are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best IHG hotels near 77221?

Holiday Inn Express Hotel & Suites Houston-Downtown Conv Ctr by I, Holiday Inn Houston S - Nrg Area - Medical Center by IHG and Holiday Inn Houston Downtown by IHG are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

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