Hotels in 29142 - Santee SC

Only hotels in 29142 zip code are listed below. Search for cheap and discount hotel rates in Santee, SC for your upcoming leisure or conference / group travel. We list the best 29142 hotels and motels so you can review the Santee hotel list below to find the perfect lodging. Hotels in Orangeburg county and area code 803 are also listed.

Star Rating
Hotel Name
Price Range (USD) to
Amenities
+ More

29142 Hotels & Accommodations

Hampton Inn Santee I 95
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
9060 Old #6 Highway, Santee, SC 29142
  • Affordable Highway hotel
  • Hotel has 81 rooms
More Photos Image of Hampton Inn Santee I 95
From$91
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Tired of clicking around? Talk to an expert Hotel Planner: (855) 276-7561 or say...
alexa hotel planner skill"Alexa, ask Hotel Planner to make a new reservation in 29142" Get Alexa Skill →
Red Roof Inn Santee
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
9091 Old No 6 Highway, Santee, SC 29142
  • 2-star Golf Course property
  • Hotel has 40 rooms
More Photos Image of Red Roof Inn Santee
From$49
Average 3.0 /5 Read Reviews Call BookMore Details
Oyo Hotel Santee Sc Lake Mario
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
628 Bass Dr., Charleston, SC 29142
  • Three Star hotel
  • Check-in: 15:00
More Photos Image of Oyo Hotel Santee Sc Lake Mario
From$90
Average 3.0 /5 Reviews Call BookMore Details
Quality Inn & Suites Santee I-95
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
8929 Bass Dr., Santee, SC 29142
  • 2-star Golf Course hotel
  • 153 rooms in property
More Photos Exterior of Quality Inn & Suites Santee I-95
From$56
Average 3.0 /5 Latest Reviews Call BookMore Details
Quality Inn & Suites
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
8929 Old Number Six Highway, Santee, SC 29142
  • Mid-scale Highway hotel
  • 2 floors in property
More Photos Image of Quality Inn & Suites
From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
Holiday Inn Santee An Ihg Hotel in Santee
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
139 Bradford Blvd., Santee, SC 29142
  • Mid-scale Highway hotel
  • Hotel has 2 meeting rooms
More Photos Image of Holiday Inn Santee An Ihg Hotel
From$80
Average 3.0 /5 Latest Reviews Call BookMore Details
Comfort Inn & Suites Santee : 221 Britain St.
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
221 Britain St., Santee, SC 29142
  • Cheap Lake property
  • Fitness / Gym is on-site
More Photos Photo of Comfort Inn & Suites Santee
From$79
Average 3.0 /5 Latest Reviews Call BookMore Details
Baymont by Wyndham Santee in Santee
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
249 Britain St., Santee, SC 29142
  • Mid-scale Highway property
  • Check in: 3pm
More Photos Exterior of Baymont by Wyndham Santee
From$80
Average 3.0 /5 Guest Reviews Call BookMore Details
Ramada by Wyndham Santee I 95 - Santee
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
123 Mall St., Santee, SC 29142
  • Low Cost Highway property
  • Hotel has 105 rooms
More Photos Image of Ramada by Wyndham Santee I 95
From$60
Average 3.0 /5 Read Reviews Call BookMore Details
Best Western Plus Santee Inn : 9059 Old Number Six Highway
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
9059 Old Number Six Highway, Santee, SC 29142
  • 2-star hotel
  • 102 rooms in property
More Photos Exterior of Best Western Plus Santee Inn
From$39
Very Good 4.5 /5 Hotel Reviews Call BookMore Details
Fairfield Inn & Suites by Marriott in Santee
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
9074 Old Highway Number Six, Santee, SC 29142
  • 3 star Highway property
  • Hotel has 91 rooms
More Photos Exterior of Fairfield Inn & Suites by Marriott
From$90
Excellent 5.0 /5 Review Score Call BookMore Details
Econo Lodge : 9112 Old Number 6 Highway
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
9112 Old Number 6 Highway, Santee, SC 29142
  • Low Cost Highway hotel
  • 37 rooms in hotel
More Photos Image of Econo Lodge
From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Travelodge by Wyndham Santee : 9117 Old Number 6 Highway
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
9117 Old Number 6 Highway, Santee, SC 29142
  • Economical Highway property
  • Comp. Breakfast
More Photos Photo of Travelodge by Wyndham Santee
From$60
Average 3.0 /5 Reviews Call BookMore Details
More Homes & Apts at Booking.com

Book online or call +1-800-219-2797

Booking for Homes and Apartments
Go to BookingGo to Booking
Super 8 by Wyndham Santee in Santee
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
9125 Old Highway 6, Santee, SC 29142
  • Cheap Highway property
  • Check-in: 2pm
More Photos Exterior of Super 8 by Wyndham Santee
From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Wyndham Vacation Resorts Lake Mario : 401 Bass Dr.
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
401 Bass Dr., Santee, SC 29412 ~1.07 miles east of 29142
  • Affordable property
More Photos hotel room
From$90
Very Good 4.0 /5 Review Score Call BookMore Details
Need some questions answered? Talk to an expert Hotel Planner: (855) 276-7561 or say...
alexa hotel planner skill"Alexa, ask Hotel Planner to make a new reservation in 29142" Get Alexa Skill →
Days Inn by Wyndham Summerton in Summerton
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
400 Buff Blvd., Summerton, SC 29148 ~10.05 miles northeast of 29142
  • Two-star property
  • Check-in: 11:00 AM
More Photos Exterior of Days Inn by Wyndham Summerton
From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Bells Marina & Resort
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
12907 Old Number Six Highway, Eutawville, SC 29048 ~12.10 miles east of 29142
  • 3 star Lake property
  • Airport shuttle provided
More Photos Exterior of Bells Marina & Resort
From$69
Average 3.0 /5 Guest Reviews Call BookMore Details
Days Inn by Wyndham Orangeburg South in Orangeburg
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
3402 Five Chop Rd., Orangeburg, SC 29115 ~13.91 miles west of 29142
  • Low Cost Highway property
  • 2 floors in hotel
More Photos Photo of Days Inn by Wyndham Orangeburg South
From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Palmetto Inn - Manning
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
6137 Alex Harvin Highway, Manning, SC 29102 ~15.87 miles northeast of 29142
  • Economical property
  • 2 floors in property
More Photos Photo of Palmetto Inn
From$60
Poor 2.0 /5 Recent Reviews Call BookMore Details
Sunset Inn Manning - Manning
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
5932 Alex Highway, Manning, SC 29102 ~15.99 miles northeast of 29142
  • Two star property
More Photos Photo of Sunset Inn Manning
From$50
Not Good 1.0 /5 Review Score Call BookMore Details
Peach Tree Inn : 111 Conners Dr.
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
111 Conners Dr., Saint George, SC 29477 ~16.02 miles south of 29142
  • Three Star Highway property
  • Check in: 3.00
More Photos Exterior of Peach Tree Inn
From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
Starlight Stays : 5342 Alex Harvin Highway
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
5342 Alex Harvin Highway, Manning, SC 29102 ~16.58 miles northeast of 29142
  • Affordable hotel
  • 20 rooms in property
More Photos Photo of Starlight Stays
From$90
Very Good 4.0 /5 Reviews Call BookMore Details
Hampton Inn Manning
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
2822 Paxville Highway, Manning, SC 29102 ~18.88 miles northeast of 29142
  • 3-star Highway property
  • Check-in time: 2:00pm
More Photos Image of Hampton Inn Manning
From$90
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Fairfield Inn by Marriott Orangeburg - Orangeburg
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
663 Citadel Rd., Orangeburg, SC 29118 ~19.92 miles west of 29142
  • Midscale Highway property
  • Check-in: 3:00 PM
More Photos Image of Fairfield Inn by Marriott Orangeburg
From$104
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Springhill Suites Orangeburg by Marriott
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
675 Citadel Rd., Orangeburg, SC 29118 ~19.99 miles west of 29142
  • Affordable hotel
  • Hotel has 88 rooms
More Photos hotel room
From$90
Average 3.0 /5 Recent Reviews Call BookMore Details
Inn at Orangeburg
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
731 Citadel Rd., Orangeburg, SC 29118 ~20.03 miles west of 29142
  • Mid-scale Highway property
  • 28 suites in property
More Photos Image of Inn at Orangeburg
From$103
Very Good 4.0 /5 Review Score Call BookMore Details
Comfort Inn & Suites in Orangeburg
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
746 Citadel Rd., Orangeburg, SC 29118 ~20.03 miles west of 29142
  • Low Cost Rural property
  • Fitness center on property
More Photos Photo of Comfort Inn & Suites
From$90
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
TRU by Hilton Orangeburg Sc : 739 Citadel Rd.
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
739 Citadel Rd., Orangeburg, SC 29118 ~20.05 miles west of 29142
  • Mid-scale hotel
  • 4 floors in property
More Photos Photo of TRU by Hilton Orangeburg Sc
From$90
Very Good 4.5 /5 Reviews Call BookMore Details
Quality Inn Manning I-95 : 3031 Paxville Highway
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
3031 Paxville Highway, Manning, FL 29102 ~20.06 miles northeast of 29142
  • Low Cost Highway property
  • 53 rooms in hotel
More Photos Image of Quality Inn Manning I-95
From$65
Average 3.0 /5 Recent Reviews Call BookMore Details
Baymont by Wyndham Manning in Manning
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
2284 Raccoon Rd., Manning, SC 29102 ~20.06 miles northeast of 29142
  • Three Star Rural property
More Photos Exterior of Baymont by Wyndham Manning
From$80
Average 3.0 /5 Latest Reviews Call BookMore Details
Hampton Inn & Suites Orangeburg : 749 Citadel Rd.
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
749 Citadel Rd., Orangeburg, SC 29118 ~20.08 miles west of 29142
  • 3 star Highway hotel
  • Comp. Breakfast
More Photos Photo of Hampton Inn & Suites Orangeburg
From$119
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Southern Lodge in Orangeburg
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
3616 St. Matthews Rd., Orangeburg, SC 29118 ~20.14 miles west of 29142
  • Two-star Highway property
  • 43 rooms in property
More Photos Image of Southern Lodge
From$49
Average 3.0 /5 Guest Reviews Call BookMore Details
Travelodge by Wyndham Orangeburg - Orangeburg
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
3620 St. Matthews Rd., Orangeburg, SC 29118 ~20.15 miles west of 29142
  • Inexpensive Highway property
  • Free complimentary breakfast
More Photos Exterior of Travelodge by Wyndham Orangeburg
From$50
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Days Inn by Wyndham Manning - Manning
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
2825 Paxville Highway, Manning, SC 29102 ~20.15 miles northeast of 29142
  • Inexpensive property
  • 57 rooms in hotel
More Photos Photo of Days Inn by Wyndham Manning
From$63
Poor 2.0 /5 Hotel Reviews Call BookMore Details
Super 8 by Wyndham Orangeburg : 3608 St. Matthews Rd.
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
3608 St. Matthews Rd., Orangeburg, SC 29118 ~20.16 miles west of 29142
  • Cheap Highway hotel
  • Check-in: 3:00pm
More Photos hotel room
From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Super 8 by Wyndham Manning in Manning
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
1062 Crossroads Church Rd., Manning, SC 29102 ~20.16 miles northeast of 29142
  • Economical Highway property
  • Check in: 3:00pm
More Photos Exterior of Super 8 by Wyndham Manning
From$55
Average 3.0 /5 Review Score Call BookMore Details
Quality Inn & Suites : 3671 St. Matthews
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
3671 St. Matthews, Orangeburg, SC 29118 ~20.17 miles west of 29142
  • Inexpensive Rural property
  • Hotel has 2 floors
More Photos Photo of Quality Inn & Suites
From$66
Average 3.0 /5 Hotel Reviews Call BookMore Details
Holiday Inn Express & Suites Orangeburg - Orangeburg
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
118 Sleep Inn Rd., Orangeburg, SC 29118 ~20.17 miles west of 29142
  • Three Star Rural property
  • Access to gym on-site
More Photos Image of Holiday Inn Express & Suites Orangeburg
From$105
Very Good 4.0 /5 Reviews Call BookMore Details
Sleep Inn Orangeburg
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
3689 St. Matthews Rd., Orangeburg, SC 29118 ~20.19 miles west of 29142
  • Two star Suburban property
  • Comp. Breakfast
More Photos hotel room
From$60
Average 3.5 /5 Guest Reviews Call BookMore Details
Days Inn by Wyndham Orangeburg
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
3691 St. Matthews Rd., Orangeburg, SC 29118 ~20.21 miles west of 29142
  • Low priced Highway hotel
  • Free breakfast
More Photos Exterior of Days Inn by Wyndham Orangeburg
From$60
Poor 2.0 /5 Review Score Call BookMore Details
SureStay by Best Western Manning
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
2816 Paxville Highway, Manning, SC 29102 ~20.27 miles northeast of 29142
  • Midscale Highway hotel
  • 6 suites in property
More Photos Image of SureStay by Best Western Manning
From$74
Very Good 4.0 /5 Reviews Call BookMore Details
Baymont by Wyndham Orangeburg North - Orangeburg
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
3583 Saint Matthews Rd., Orangeburg, SC 29118 ~20.27 miles west of 29142
  • Low Cost Highway hotel
  • Check in: 3:00 PM
More Photos Exterior of Baymont by Wyndham Orangeburg North
From$58
Average 3.0 /5 Recent Reviews Call BookMore Details
American INN of Orangeburg : 610 John C. Calhoun Dr.
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
610 John C. Calhoun Dr., Orangeburg, SC 29115 ~21.18 miles west of 29142
  • Cheap Highway hotel
  • Check in time: 2:00 PM
More Photos Exterior of American INN of Orangeburg
From$60
Average 3.0 /5 Reviews Call BookMore Details
Palmetto Inn & Suites in Orangeburg
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
826 John C Calhoun Dr., Orangeburg, SC 29115 ~21.59 miles west of 29142
  • Three Star property
  • 3 floors in property
More Photos hotel room
From$40
Average 3.0 /5 Hotel Reviews Call BookMore Details
Red Roof St. George in St George
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
133 Winningham Rd., St George, SC 29477 ~21.61 miles south of 29142
  • Inexpensive property
  • 57 rooms in property
More Photos hotel room
From$60
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Quality Inn St George I-95
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
6014 West Jim Bilton Blvd., Saint George, SC 29477 ~21.63 miles south of 29142
  • 3 star Rural hotel
  • Gym / Fitness Center Available
More Photos Exterior of Quality Inn St George I-95
From$80
Poor 2.0 /5 Recent Reviews Call BookMore Details
Econo Lodge St George - St. George
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
5971 West Jim Bilton Blvd., St. George, SC 29477 ~21.64 miles south of 29142
  • Low priced Highway hotel
  • 67 sleeping rooms in hotel
More Photos Photo of Econo Lodge St George
From$40
Very Good 4.0 /5 Reviews Call BookMore Details
Elite Inn - Walterboro
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
115 Winningham Rd., Walterboro, SC 29477 ~21.68 miles south of 29142
  • Two star Downtown property
  • 45 rooms in hotel
More Photos Image of Elite Inn
From$55
Very Good 4.0 /5 Read Reviews Call BookMore Details
Knights Inn Saint George - Saint George Sc
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
114 Winningham Rd., Saint George Sc, SC 29477 ~21.68 miles south of 29142
  • Two star hotel
  • 2 floors in property
More Photos Exterior of Knights Inn Saint George
From$39
Poor 2.0 /5 Read Reviews Call BookMore Details
Days Inn by Wyndham St George : 139 Frontage Rd.
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
139 Frontage Rd., St. George, SC 29477 ~21.73 miles south of 29142
  • Two-star property
  • Check-in: 15:00
More Photos Exterior of Days Inn by Wyndham St George
From$66
Average 3.0 /5 Latest Reviews Call BookMore Details

Next: Show All Available 29142 Hotels with Pricing

Graph of Santee, SC Hotel Prices for Next 20 Days

Rates shown are nightly rates before taxes and do not necessarily reflect all Santee, SC discounts available. The chart reflects the cheapest Santee hotel for each day and each star rating category.

FAQs about hotels near 29142

What are the top reviewed hotels near 29142?

Fairfield Inn & Suites by Marriott, Best Western Plus Santee Inn and TRU by Hilton Orangeburg Sc are the best rated hotels based on customer reviews in the last 365 days.

What are the 4-5 star hotels near 29142?

Hampton Inn Santee I 95, Oyo Hotel Santee Sc Lake Mario and Quality Inn & Suites are the top 3 luxury hotels near 29142.

What hotels are closest to the area of 29142?

Hampton Inn Santee I 95, Red Roof Inn Santee, and Oyo Hotel Santee Sc Lake Mario are the properties closest to 29142.

How much does a cheap hotel near 29142 cost per night?

In the last year, a 2 star hotel near 29142 can be as cheap as $96.24 per night. (based on HotelPlanner prices)

How much does a 3 star hotel near 29142 cost per night?

In the last year, the average 3 star hotel near 29142 has been $124.70 per night. (based on HotelPlanner prices)

What are the best independent hotels near 29142?

Starlight Stays, Inn at Orangeburg and Elite Inn are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels near 29142?

Fairfield Inn & Suites by Marriott, Fairfield Inn by Marriott Orangeburg and Springhill Suites Orangeburg by Marriott are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the most popular Choice Hotels branded hotels near 29142?

Comfort Inn & Suites, Econo Lodge St George and Sleep Inn Orangeburg are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the best Best Western hotels near 29142?

Best Western Plus Santee Inn and SureStay by Best Western Manning are the best rated Best Western branded hotels (based on user reviews score).

What are the most popular IHG hotels near 29142?

Holiday Inn Express & Suites Orangeburg and Holiday Inn Santee An Ihg Hotel are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

Back to Top