Hotels in 78221 - San Antonio TX

Only hotels in 78221 zip code are listed below. Search for cheap and discount hotel rates in San Antonio, TX for your upcoming leisure or conference / group travel. We list the best 78221 hotels and motels so you can review the San Antonio hotel list below to find the perfect lodging. Hotels in Bexar county and area code 210 are also listed.

78221 Hotels/Motels & Accommodations

Holiday Inn Express & Suites San Antonio South 410
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
11400 SE Loop 410 Acc Rd., San Antonio, TX 78221 +1-888-389-4121
  • 3-star Suburban hotel
  • 80 rooms in hotel
More Photos
From$80
Average 3.0 /5 Read Reviews Call BookMore Details
Best Western Plus Palo Alto Inn & Suites - San Antonio
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
12507 SW Loop 410, San Antonio, TX 78224 +1-888-675-2083 ~4.15 miles northwest of 78221
  • 3-star hotel
  • 75 rooms in hotel
More Photos
From$58
Very Good 4.0 /5 Reviews Call BookMore Details
Days Inn by Wyndham San Antonio at Palo Alto
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
9403 Poteet Jourdanton Freeway, San Antonio, TX 78224 +1-800-716-8490 ~4.59 miles northwest of 78221
  • Cheap Downtown property
  • Check in time: 11:00 AM
More Photos
From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Woodspring Suites San Antonio South - San Antonio
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
7958 Interstate 35 Access Rd., San Antonio, TX 78224 +1-800-805-5223 ~5.59 miles north of 78221
  • 2-star Highway hotel
  • Check in time: 3:00 PM
More Photos
From$43
Average 3.0 /5 Guest Reviews Call BookMore Details
Baymont by Wyndham San Antonio South Park - San Antonio
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
7202 South Pan Am Expressway, San Antonio, TX 78224 +1-888-965-1860 ~5.96 miles north of 78221
  • 3 star Highway property
  • Free complimentary breakfast
More Photos
From$80
Poor 2.0 /5 Guest Reviews Call BookMore Details
Motel 6 San Antonio, TX - South : 7950 South Panam Expy
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
7950 South Panam Expy, San Antonio, TX 78224 +1-888-788-5576 ~6.31 miles north of 78221
  • Two-star property
  • 75 rooms in hotel
More Photos
From$60
Poor 2.5 /5 Reviews Call BookMore Details
Embassy Suites by Hilton San Antonio Brooks Hotel & Spa - San Antonio
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
7610 South New Braunfels, San Antonio, TX 78235 +1-888-897-9207 ~6.87 miles northeast of 78221
  • 4-star Downtown property
  • Hotel has 5 floors
More Photos
From$125
Average 3.0 /5 Recent Reviews Call BookMore Details
Best Western Plus Elmendorf Hotel / San Antonio Hotel
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
20015 Eagle Ford Way, Elmendorf, TX 78112 +1-888-311-4278 ~6.95 miles east of 78221
  • Mid-scale Highway hotel
  • Hotel has a green policy Learn more
More Photos
From$80
Very Good 4.0 /5 Reviews Call BookMore Details
Holiday Inn Express & Suites San Antonio Brooks Cb
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
8222 City Base Landing, San Antonio, TX 78235 +1-888-469-4795 ~7.27 miles northeast of 78221
  • 3-star Suburban hotel
  • Gym is available on property
More Photos
From$52
Average 3.0 /5 Guest Reviews Call BookMore Details
Hampton Inn & Suites San Antonio City Base Landing : 8202 City Base Landing
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
8202 City Base Landing, San Antonio, TX 78235 +1-888-734-9421 ~7.39 miles northeast of 78221
  • 3-star Suburban property
  • 32 suites in property
More Photos
From$68
Very Good 4.0 /5 Review Score Call BookMore Details
La Quinta Inn by Wyndham San Antonio Brooks City Base
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
3180 Goliad Rd., San Antonio, TX 78223 +1-888-841-5292 ~7.55 miles northeast of 78221
  • Low Cost Suburban property
  • Airport shuttle provided
More Photos
From$62
Average 3.0 /5 Hotel Reviews Call BookMore Details
Econo Lodge Downtown South : 606 Division Ave.
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
606 Division Ave., San Antonio, TX 78214 +1-888-455-5160 ~7.59 miles north of 78221
  • Low Cost hotel
  • Check in: 12:00
More Photos
From$60
Poor 2.0 /5 Review Score Call BookMore Details
Fairfield Inn & Suites San Antonio Brooks City Base
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
3234 Goliad Rd., San Antonio, TX 78223 +1-888-965-8297 ~7.61 miles northeast of 78221
  • Three Star Suburban property
  • Fitness center on property
More Photos
From$61
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Motel 6 San Antonio, TX - Downtown - Alamo Dome - San Antonio
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
748 Hot Wells Blvd., San Antonio, TX 78223 +1-888-906-6358 ~7.76 miles northeast of 78221
  • Cheap Downtown hotel
  • 74 rooms in hotel
More Photos
From$30
Poor 2.5 /5 Hotel Reviews Call BookMore Details
Super 8 by Wyndham San Antonio/Alamodome Area : 723 Hot Wells
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
723 Hot Wells, San Antonio, TX 78223 +1-888-749-6785 ~7.78 miles northeast of 78221
  • Two star Downtown property
  • Fitness center on property
More Photos
From$60
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Quality Suites San Antonio - San Antonio
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
3602 SE Military Dr., San Antonio, TX 78223 +1-888-878-9982 ~7.89 miles northeast of 78221
  • Mid-scale Suburban hotel
  • Fitness + Health Center
More Photos
From$49
Average 3.0 /5 Review Score Call BookMore Details
Econo Lodge Inn & Suites - San Antonio
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
120 Rustleaf Dr., San Antonio, TX 78242 +1-888-389-4485 ~8.76 miles northwest of 78221
  • Low priced hotel
  • Check-in time: 11:00 AM
More Photos
From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Econo Lodge Inn & Suites Near Lackland AFB : Rustleaf & SW Military Dr.
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
Rustleaf & SW Military Dr., San Antonio, TX 78242 +1-888-389-4121 ~8.78 miles northwest of 78221
  • Low-priced hotel
More Photos
From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Stay Nixon
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
423 Blue Star, San Antonio, TX 78204 +1-888-675-2083 ~9.45 miles north of 78221
  • High end Downtown property
  • Hotel has 41 suites
More Photos
From$99
Average 3.0 /5 Review Score Call BookMore Details
Sonder Southtown Suites - San Antonio
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
111 Probandt St., San Antonio, TX 78204 +1-800-716-8490 ~9.57 miles north of 78221
  • Four star Downtown hotel
  • 15 suites in property
More Photos
From$75
Average 3.0 /5 Latest Reviews Call BookMore Details
The Inn at Market Square : 1500 I 35 South Exit 154b Laredo St.
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
1500 I 35 South Exit 154b Laredo St., San Antonio, TX 78204 +1-800-805-5223 ~9.74 miles north of 78221
  • 2-star Downtown hotel
  • Free breakfast
More Photos
From$35
Poor 2.0 /5 Read Reviews Call BookMore Details
Days Inn & Suites by Wyndham Braunig Lake
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
13800 Ih 37 South, Elmendorf, TX 78112 +1-888-965-1860 ~9.89 miles east of 78221
  • Two star Lake hotel
  • 2 floors in hotel
More Photos
From$59
Very Good 4.0 /5 Read Reviews Call BookMore Details
Econo Lodge Inn & Suites Downtown San Antonio Riverwalk Area
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
1122 South Laredo St., San Antonio, TX 78204 +1-888-788-5576 ~10.06 miles north of 78221
  • Two star Downtown hotel
  • Access to gym on-site
More Photos
From$30
Not Good 1.5 /5 Recent Reviews Call BookMore Details
Super 8 by Wyndham San Antonio/Riverwalk Area
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
302 Roland Ave., San Antonio, TX 78210 +1-888-897-9207 ~10.08 miles north of 78221
  • Cheap Downtown property
  • 55 sleeping rooms in hotel
More Photos
From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Candlewood Suites San Antonio Downtown An Ihg Hotel - San Antonio
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
1024 South Laredo St., San Antonio, TX 78204 +1-888-311-4278 ~10.08 miles north of 78221
  • Low Cost Downtown hotel
  • 96 rooms in property
More Photos
From$90
Average 3.0 /5 Review Score Call BookMore Details
Quality Inn Downtown - near Market Square : 1025 South Frio St.
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
1025 South Frio St., San Antonio, TX 78207 +1-888-469-4795 ~10.12 miles north of 78221
  • Cheap Downtown hotel
  • Comp. Breakfast
More Photos
From$60
Very Good 4.0 /5 Review Score Call BookMore Details
Best Western Alamo Suites
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
1002 South Laredo St., San Antonio, TX 78204 +1-888-734-9421 ~10.15 miles north of 78221
  • Mid-scale Downtown property
  • 72 suites in property
More Photos
From$75
Very Good 4.0 /5 Reviews Call BookMore Details
Best Western Plus Roland Inn & Suites
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
333 Roland Ave., San Antonio, TX 78210 +1-888-841-5292 ~10.20 miles north of 78221
  • Three Star hotel
  • 4 floors in property
More Photos
From$58
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
River Inn Motel in San Antonio
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
909 South Frio St., San Antonio, TX 78207 +1-888-455-5160 ~10.20 miles north of 78221
  • Economy Downtown hotel
  • 20 rooms in property
More Photos
From$60
Very Good 4.0 /5 Reviews Call BookMore Details
Holiday Inn Express & Suites San Antonio Dtwn Market Area
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
102 El Paso St., San Antonio, TX 78204 +1-888-965-8297 ~10.27 miles north of 78221
  • Economy Downtown hotel
  • 78 suites in property
More Photos
From$65
Very Good 4.0 /5 Reviews Call BookMore Details
Residence Inn San Antonio Market Square Downtown : 628 South Santa Rosa Ave.
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
628 South Santa Rosa Ave., San Antonio, TX 78204 +1-888-906-6358 ~10.39 miles north of 78221
  • Three Star Downtown hotel
  • Access to gym on-site
More Photos
From$80
Average 3.0 /5 Reviews Call BookMore Details
Sonder La Villita - San Antonio
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
633 South St. Mary's St., San Antonio, TX 78205 +1-888-749-6785 ~10.41 miles north of 78221
  • 4-star Downtown property
  • Hotel has 5 floors
More Photos
From$75
Average 3.0 /5 Review Score Call BookMore Details
Fairfield Inn & Suites San Antonio Downtown / Market Square
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
620 South Santa Rosa Ave., San Antonio, TX 78204 +1-888-878-9982 ~10.42 miles north of 78221
  • Three Star Downtown hotel
  • Check in time: 03:00 PM
More Photos
From$80
Average 3.0 /5 Latest Reviews Call BookMore Details
Plaza San Antonio Hotel & Spa, Autograph Collection - San Antonio
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
555 South Alamo St., San Antonio, TX 78205 +1-888-389-4485 ~10.44 miles north of 78221
  • Expensive Downtown property
  • Hotel has 246 rooms
More Photos
From$121
Very Good 4.0 /5 Recent Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham San Antonio Downtown - San Antonio
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
100 West Cesar Chavez Blvd., San Antonio, TX 78204 +1-888-389-4121 ~10.44 miles north of 78221
  • Mid-scale Downtown hotel
  • 151 sleeping rooms in hotel
More Photos
From$89
Very Good 4.0 /5 Review Score Call BookMore Details
Hyatt Place San Antonio Riverwalk - San Antonio
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
601 South St. Mary's St., San Antonio, TX 78205 +1-888-675-2083 ~10.46 miles north of 78221
  • Affordable Downtown property
  • 131 rooms in property
More Photos
From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
Hampton Inn & Suites San Antonio-Downtown/Market Square
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
411 South Flores St., San Antonio, TX 78204 +1-800-716-8490 ~10.47 miles north of 78221
  • Midscale Downtown property
  • Check-in time: 3:00PM
More Photos
From$120
Average 3.0 /5 Guest Reviews Call BookMore Details
Inn on the Riverwalk : 129 Woodward Place
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
129 Woodward Place, San Antonio, TX 78204 +1-800-805-5223 ~10.48 miles north of 78221
  • Mid-scale Downtown property
  • Check-in: 3:00 pm
More Photos
From$119
Very Good 4.0 /5 Read Reviews Call BookMore Details
Courtyard by Marriott San Antonio Downtown/Market Square in San Antonio
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
600 South Santa Rosa Ave., San Antonio, TX 78204 +1-888-965-1860 ~10.48 miles north of 78221
  • Midscale Downtown property
  • 12 suites in property
More Photos
From$119
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Holiday Inn San Antonio - Dwtn - Market Sq, an IHG Hotel in San Antonio
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
318 West César East Chávez Blvd., San Antonio, TX 78204 +1-888-788-5576 ~10.49 miles north of 78221
  • Mid-scale hotel
  • Fitness + Health Center
More Photos
From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
SpringHill Suites San Antonio Downtown/Riverwalk Area
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
524 South St. Mary's St., San Antonio, TX 78205 +1-888-897-9207 ~10.50 miles north of 78221
  • 3 star Convention Center property
  • 4 meeting rooms in hotel
More Photos
From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Holiday Inn Downtown Market Square
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
318 West Durango Blvd., San Antonio, TX 78204 +1-888-311-4278 ~10.51 miles north of 78221
  • Midscale Downtown property
  • Hotel has 4 floors
More Photos
From$74
Average 3.5 /5 Latest Reviews Call BookMore Details
Holiday Inn San Antonio - Dwtn - Market Sq, an IHG Hotel
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
318 West Cesar East Chavez Blvd., San Antonio, TX 78204 +1-888-469-4795 ~10.52 miles north of 78221
  • Mid-scale Downtown property
  • Has environment-friendly policy Read more
More Photos
From$56
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Club Wyndham La Cascada
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
226 Dwyer Ave., San Antonio, TX 78204 +1-888-734-9421 ~10.54 miles north of 78221
  • High-end Downtown hotel
  • 97 rooms in property
More Photos
From$85
Very Good 4.0 /5 Read Reviews Call BookMore Details
Fairmount Hotel in San Antonio
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
401 South Alamo St., San Antonio, TX 78205 +1-888-841-5292 ~10.55 miles north of 78221
  • High end Downtown property
  • 2 meeting rooms in property
More Photos
From$189
Average 3.0 /5 Latest Reviews Call BookMore Details
Doubletree by Hilton San Antonio Downtown
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
502 West Cesar East Chavez Blvd., San Antonio, TX 78207 +1-888-455-5160 ~10.56 miles north of 78221
  • 3 star Downtown hotel
  • 22 suites in hotel
More Photos
From$67
Average 3.0 /5 Review Score Call BookMore Details
Doubletree by Hilton San Antonio Downtown in San Antonio
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
502 West César East Chávez Blvd., San Antonio, TX 78207 +1-888-965-8297 ~10.57 miles north of 78221
  • 3 star Downtown property
  • 13 meeting rooms in hotel
More Photos
From$75
Average 3.0 /5 Hotel Reviews Call BookMore Details
O´Brien Historic Hotel
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
116 Navarrro St., San Antonio, TX 78205 +1-888-906-6358 ~10.59 miles north of 78221
  • 3 star Downtown property
  • Check-in: 3:00PM
More Photos
From$77
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Stay Express Inn & Suites
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
100 Valley Hi Dr., San Antonio, TX 78227 +1-888-749-6785 ~10.63 miles northwest of 78221
  • Cheap Suburban hotel
  • Free breakfast available
More Photos
From$37
Poor 2.0 /5 Read Reviews Call BookMore Details
Staybridge Suites San Antonio Downtown Conv Ctr by IHG
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
123 Hoefgen Ave., San Antonio, TX 78205 +1-888-878-9982 ~10.66 miles north of 78221
  • Mid-scale Downtown hotel
  • Free breakfast
More Photos
From$105
Very Good 4.0 /5 Review Score Call BookMore Details
Back to Top