Hotels in 78221 - San Antonio TX

Only hotels in 78221 zip code are listed below. Search for cheap and discount hotel rates in San Antonio, TX for your upcoming leisure or conference / group travel. We list the best 78221 hotels and motels so you can review the San Antonio hotel list below to find the perfect lodging. Hotels in Bexar county and area code 210 are also listed.

78221 Hotels & Accommodations

Holiday Inn Express & Suites San Antonio South - San Antonio
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
11400 SE Loop 410 Acc Rd., San Antonio, TX 78221 +1-888-389-4121
  • Affordable Suburban property
  • Gym is available on property
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From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
Best Western Plus Palo Alto Inn & Suites - San Antonio
+1-888-675-2083

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New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
12507 SW Loop 410, San Antonio, TX 78224 +1-888-675-2083 ~4.15 miles northwest of 78221
  • Affordable hotel
  • 75 rooms in hotel
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From$59
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Days Inn by Wyndham San Antonio at Palo Alto
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
9403 Poteet Jourdanton Freeway, San Antonio, TX 78224 +1-800-716-8490 ~4.59 miles northwest of 78221
  • Cheap Downtown hotel
  • Comp. Breakfast
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From$60
Average 3.0 /5 Reviews Call BookMore Details
Woodspring Suites San Antonio South : 7958 Interstate 35 Access Rd.
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
7958 Interstate 35 Access Rd., San Antonio, TX 78224 +1-800-805-5223 ~5.59 miles north of 78221
  • 2 star Highway hotel
  • Check in time: 3:00 PM
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From$43
Average 3.0 /5 Review Score Call BookMore Details
Baymont by Wyndham San Antonio South Park in San Antonio
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
7202 South Pan Am Expressway, San Antonio, TX 78224 +1-888-965-1860 ~5.96 miles north of 78221
  • 3 star Highway hotel
  • Hotel has 2 floors
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From$80
Poor 2.0 /5 Latest Reviews Call BookMore Details
Motel 6 San Antonio, TX - South in San Antonio
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
7950 South Panam Expy, San Antonio, TX 78224 +1-888-788-5576 ~6.31 miles north of 78221
  • Economical property
  • Check-in: 13:00
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From$60
Poor 2.5 /5 Latest Reviews Call BookMore Details
Embassy Suites by Hilton San Antonio Brooks Hotel & Spa
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
7610 South New Braunfels, San Antonio, TX 78235 +1-888-897-9207 ~6.81 miles northeast of 78221
  • 3-star Suburban hotel
  • Free breakfast available
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From$102
Very Good 4.0 /5 Review Score Call BookMore Details
Embassy Suites by Hilton San Antonio Brooks Hotel & Spa
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
7610 South New Braunfels San Antonio Tx 78235, San Antonio, TX 78223 +1-888-311-4278 ~6.87 miles northeast of 78221
  • Four star hotel
  • 156 suites in hotel
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From$125
Average 3.0 /5 Guest Reviews Call BookMore Details
Best Western Plus Elmendorf Hotel : 20015 Eagle Ford Way
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
20015 Eagle Ford Way, Elmendorf, TX 78112 +1-888-469-4795 ~6.95 miles east of 78221
  • Mid-scale Highway property
  • Fitness / Gym is on-site
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From$80
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Holiday Inn Express & Suites San Antonio Brooks Cb - San Antonio
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
8222 City Base Landing, San Antonio, TX 78235 +1-888-734-9421 ~7.27 miles northeast of 78221
  • Mid-scale Suburban hotel
  • Access to gym on-site
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From$52
Average 3.0 /5 Guest Reviews Call BookMore Details
Hampton Inn & Suites San Antonio City Base Landing - San Antonio
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
8202 City Base Landing, San Antonio, TX 78235 +1-888-841-5292 ~7.39 miles northeast of 78221
  • Three Star Suburban property
  • Comp. Breakfast
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From$68
Very Good 4.0 /5 Recent Reviews Call BookMore Details
La Quinta Inn by Wyndham San Antonio Brooks City Base in San Antonio
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
3180 Goliad Rd., San Antonio, TX 78223 +1-888-455-5160 ~7.55 miles northeast of 78221
  • Two-star Suburban property
  • Shuttle from airport available
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From$62
Average 3.0 /5 Review Score Call BookMore Details
Econo Lodge Downtown South in San Antonio
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
606 Division Ave., San Antonio, TX 78214 +1-888-965-8297 ~7.59 miles north of 78221
  • 2 star property
  • Free breakfast available
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From$60
Poor 2.0 /5 Hotel Reviews Call BookMore Details
Fairfield Inn & Suites San Antonio Brooks City Base
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
3234 Goliad Rd., San Antonio, TX 78223 +1-888-906-6358 ~7.61 miles northeast of 78221
  • 3 star Suburban hotel
  • Check-in: 4pm
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From$61
Very Good 4.0 /5 Reviews Call BookMore Details
Motel 6 San Antonio, TX - Downtown - Alamo Dome
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
748 Hot Wells Blvd., San Antonio, TX 78223 +1-888-749-6785 ~7.76 miles northeast of 78221
  • Economical Downtown hotel
  • 3 floors in hotel
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From$30
Poor 2.5 /5 Reviews Call BookMore Details
Super 8 by Wyndham San Antonio/Alamodome Area : 723 Hot Wells
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
723 Hot Wells, San Antonio, TX 78223 +1-888-878-9982 ~7.78 miles northeast of 78221
  • Two-star Downtown property
  • Free comp. breakfast
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From$60
Very Good 4.0 /5 Review Score Call BookMore Details
Quality Suites San Antonio
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
3602 SE Military Dr., San Antonio, TX 78223 +1-888-389-4485 ~7.89 miles northeast of 78221
  • Midscale Suburban hotel
  • Gym / Fitness Center Available
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From$49
Average 3.0 /5 Reviews Call BookMore Details
Econo Lodge Inn & Suites - San Antonio
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
120 Rustleaf Dr., San Antonio, TX 78242 +1-888-389-4121 ~8.76 miles northwest of 78221
  • Inexpensive property
  • Check in time: 11:00 AM
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From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Econo Lodge Inn & Suites Near Lackland AFB in San Antonio
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
Rustleaf & SW Military Dr., San Antonio, TX 78242 +1-888-675-2083 ~8.78 miles northwest of 78221
  • 2 star property
  • 32 sleeping rooms in hotel
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From$60
Average 3.0 /5 Read Reviews Call BookMore Details
Stay Nixon : 423 Blue Star
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
423 Blue Star, San Antonio, TX 78204 +1-800-716-8490 ~9.45 miles north of 78221
  • 4 star Downtown property
  • 4 floors in property
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From$99
Average 3.0 /5 Review Score Call BookMore Details
Sonder Southtown Suites in San Antonio
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
111 Probandt St., San Antonio, TX 78204 +1-800-805-5223 ~9.57 miles north of 78221
  • High end Downtown hotel
  • Check in time: 4:00pm
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From$75
Average 3.0 /5 Review Score Call BookMore Details
The Inn at Market Square
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
1500 I 35 South Exit 154b Laredo St., San Antonio, TX 78204 +1-888-965-1860 ~9.74 miles north of 78221
  • Economical Downtown hotel
  • 2 floors in property
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From$35
Poor 2.0 /5 Guest Reviews Call BookMore Details
Days Inn & Suites by Wyndham Braunig Lake
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
13800 Ih 37 South, Elmendorf, TX 78112 +1-888-788-5576 ~9.89 miles east of 78221
  • Inexpensive Lake property
  • 62 rooms in property
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From$59
Very Good 4.0 /5 Review Score Call BookMore Details
Econo Lodge Inn & Suites Downtown San Antonio Riverwalk Area in San Antonio
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
1122 South Laredo St., San Antonio, TX 78204 +1-888-897-9207 ~10.06 miles north of 78221
  • Economy Downtown hotel
  • 50 rooms in property
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From$30
Not Good 1.5 /5 Recent Reviews Call BookMore Details
Super 8 by Wyndham San Antonio/Riverwalk Area
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
302 Roland Ave., San Antonio, TX 78210 +1-888-311-4278 ~10.08 miles north of 78221
  • Two-star Downtown hotel
  • 2 floors in hotel
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From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Candlewood Suites San Antonio Downtown An Ihg Hotel : 1024 South Laredo St.
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
1024 South Laredo St., San Antonio, TX 78204 +1-888-469-4795 ~10.08 miles north of 78221
  • Cheap Downtown hotel
  • 4 floors in hotel
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From$90
Average 3.0 /5 Hotel Reviews Call BookMore Details
Quality Inn Downtown - near Market Square
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
1025 South Frio St., San Antonio, TX 78207 +1-888-734-9421 ~10.12 miles north of 78221
  • Low priced Downtown property
  • 85 rooms in property
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From$60
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Best Western Alamo Suites : 1002 South Laredo St.
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
1002 South Laredo St., San Antonio, TX 78204 +1-888-841-5292 ~10.15 miles north of 78221
  • Affordable Downtown property
  • Check-in time: 03:00
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From$75
Very Good 4.0 /5 Review Score Call BookMore Details
Best Western Plus Roland Inn & Suites - San Antonio
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
333 Roland Ave., San Antonio, TX 78210 +1-888-455-5160 ~10.20 miles north of 78221
  • 3-star property
  • Hotel has 69 rooms
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From$59
Very Good 4.0 /5 Read Reviews Call BookMore Details
River Inn Motel
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
909 South Frio St., San Antonio, TX 78207 +1-888-965-8297 ~10.20 miles north of 78221
  • Low priced Downtown hotel
  • Hotel has a green policy See more
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From$60
Very Good 4.0 /5 Read Reviews Call BookMore Details
Holiday Inn Express & Suites San Antonio Dtwn Market Area in San Antonio
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
102 El Paso St., San Antonio, TX 78204 +1-888-906-6358 ~10.27 miles north of 78221
  • 2-star Downtown hotel
  • Free comp. breakfast
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From$65
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Residence Inn by Marriott San Antonio Downtown Market Square - San Antonio
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
628 South Santa Rosa Ave., San Antonio, TX 78204 +1-888-749-6785 ~10.39 miles north of 78221
  • 3-star Downtown property
  • Hotel has 36 suites
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From$109
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Sonder La Villita
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
633 South St. Mary's St., San Antonio, TX 78205 +1-888-878-9982 ~10.41 miles north of 78221
  • High-end Downtown hotel
  • Fitness + Health Center
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From$75
Average 3.0 /5 Hotel Reviews Call BookMore Details
Fairfield Inn & Suites San Antonio Downtown / Market Square - San Antonio
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
620 South Santa Rosa Ave., San Antonio, TX 78204 +1-888-389-4485 ~10.42 miles north of 78221
  • Affordable Downtown property
  • Hotel has 4 floors
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From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Plaza San Antonio Hotel & Spa, Autograph Collection
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
555 South Alamo St., San Antonio, TX 78205 +1-888-389-4121 ~10.44 miles north of 78221
  • Four-star Downtown property
  • Check-in time: 4:00 PM
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From$121
Very Good 4.0 /5 Guest Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham San Antonio Downtown
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
100 West Cesar Chavez Blvd., San Antonio, TX 78204 +1-888-675-2083 ~10.44 miles north of 78221
  • Midscale Downtown hotel
  • Gym is available on property
More Photos
From$89
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Hyatt Place San Antonio Riverwalk
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
601 South St. Mary's St., San Antonio, TX 78205 +1-800-716-8490 ~10.46 miles north of 78221
  • Affordable Downtown hotel
  • Fitness + Health Center
More Photos
From$80
Average 3.0 /5 Read Reviews Call BookMore Details
Hampton Inn & Suites San Antonio-Downtown/Market Square - San Antonio
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
411 South Flores St., San Antonio, TX 78204 +1-800-805-5223 ~10.47 miles north of 78221
  • 3-star Downtown hotel
  • Free comp. breakfast
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From$120
Average 3.0 /5 Latest Reviews Call BookMore Details
Inn on the Riverwalk in San Antonio
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
129 Woodward Place, San Antonio, TX 78204 +1-888-965-1860 ~10.48 miles north of 78221
  • 3-star Downtown property
  • 13 rooms in property
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From$119
Very Good 4.0 /5 Review Score Call BookMore Details
Courtyard by Marriott San Antonio Downtown/Market Square
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
600 South Santa Rosa Ave., San Antonio, TX 78204 +1-888-788-5576 ~10.48 miles north of 78221
  • 3-star Downtown hotel
  • Check in time: 3:00PM
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From$119
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Holiday Inn San Antonio - Dwtn - Market Sq, an IHG Hotel - San Antonio
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
318 West César East Chávez Blvd., San Antonio, TX 78204 +1-888-897-9207 ~10.49 miles north of 78221
  • Three Star hotel
  • Check-in time: 4:00pm
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From$80
Average 3.0 /5 Reviews Call BookMore Details
Springhill Suites by Marriott San Antonio Downtown / Riverwalk Ar
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
524 South St. Mary's St., San Antonio, TX 78205 +1-888-311-4278 ~10.50 miles north of 78221
  • Affordable Convention Center property
  • Fitness / Gym is on-site
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From$80
Average 3.0 /5 Latest Reviews Call BookMore Details
Holiday Inn Downtown Market Square
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
318 West Durango Blvd., San Antonio, TX 78204 +1-888-469-4795 ~10.51 miles north of 78221
  • Affordable Downtown hotel
  • Hotel has 313 rooms
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From$74
Average 3.5 /5 Guest Reviews Call BookMore Details
Holiday Inn San Antonio - Dwtn - Market Sq, an IHG Hotel
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
318 West Cesar East Chavez Blvd., San Antonio, TX 78204 +1-888-734-9421 ~10.52 miles north of 78221
  • 3 star Downtown property
  • 2 suites in property
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From$56
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Club Wyndham La Cascada - San Antonio
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
226 Dwyer Ave., San Antonio, TX 78204 +1-888-841-5292 ~10.54 miles north of 78221
  • High-end Downtown hotel
  • Fitness + Health Center
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From$85
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Fairmount Hotel
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
401 South Alamo St., San Antonio, TX 78205 +1-888-455-5160 ~10.55 miles north of 78221
  • 4 star Downtown hotel
  • 2 conference rooms in property
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From$189
Average 3.0 /5 Guest Reviews Call BookMore Details
Doubletree by Hilton San Antonio Downtown - San Antonio
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
502 West César East Chávez Blvd., San Antonio, TX 78207 +1-888-965-8297 ~10.57 miles north of 78221
  • Mid-scale Downtown property
  • 20 suites in property
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From$75
Average 3.0 /5 Review Score Call BookMore Details
O´Brien Historic Hotel in San Antonio
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
116 Navarrro St., San Antonio, TX 78205 +1-888-906-6358 ~10.59 miles north of 78221
  • 3-star Downtown property
  • Complimentary breakfast is offered
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From$77
Very Good 4.0 /5 Reviews Call BookMore Details
Embassy Suites San Antonio Brooks : 502 West Cesar East Chavez
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
502 West Cesar East Chavez, San Antonio, TX 78207 +1-888-749-6785 ~10.60 miles north of 78221
  • Affordable Downtown property
  • Hotel has 250 rooms
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From$89
Average 3.5 /5 Guest Reviews Call BookMore Details
Stay Express Inn & Suites in San Antonio
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
100 Valley Hi Dr., San Antonio, TX 78227 +1-888-878-9982 ~10.63 miles northwest of 78221
  • Low priced Suburban hotel
  • 62 sleeping rooms in hotel
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From$37
Poor 2.0 /5 Read Reviews Call BookMore Details
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