45621 Hotels/Motels & Accommodations

Quality Inn
+1-888-389-4121
605 East Main St., Jackson, OH 45640 +1-888-389-4121 ~5.14 miles south of 45621
  • 3-star property
  • Check-in: 15:00
From$90
Average 3.0 /5 Guest Reviews Call BookMore Details
Red Roof Inn Jackson, OH
+1-888-675-2083
1000 Acy Ave., Jackson, OH 45640 +1-888-675-2083 ~5.29 miles south of 45621
  • Two star Rural hotel
  • Hotel has 2 floors
From$60
Average 3.0 /5 Read Reviews Call BookMore Details
Days Inn by Wyndham Jackson in Jackson
+1-800-716-8490
972 East Main St., Jackson, OH 45640 +1-800-716-8490 ~5.30 miles south of 45621
  • Two star Rural hotel
  • Free breakfast
From$84
Average 3.0 /5 Hotel Reviews Call BookMore Details
Comfort Inn in Piketon
+1-800-805-5223
7525 Us 23, Piketon, OH 45661 +1-800-805-5223 ~21.75 miles west of 45621
  • Affordable Lake property
  • 70 rooms in hotel
From$80
Very good 4.0 /5 Guest Reviews Call BookMore Details
Americas Best Value Inn Chillicothe - Chillicothe
+1-888-965-1860
1135 East Main St., Chillicothe, OH 45601 +1-888-965-1860 ~23.81 miles northwest of 45621
  • Two-star Highway property
  • Free comp. breakfast
From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Holiday Inn Express Chillicothe East by IHG - Chillicothe
+1-888-788-5576
1003 East Main St., Chillicothe, OH 45601 +1-888-788-5576 ~23.89 miles northwest of 45621
  • 3 star Suburban property
  • Hotel has 3 floors
From$87
Very good 4.0 /5 Recent Reviews Call BookMore Details
Christopher Inn and Suites
+1-888-897-9207
30 North Plaza Blvd., Chillicothe, OH 45601 +1-888-897-9207 ~25.45 miles northwest of 45621
  • Midscale Highway hotel
  • 2 floors in hotel
From$85
Very good 4.5 /5 Hotel Reviews Call BookMore Details
Quality Inn
+1-888-311-4278
20 North Plaza Blvd., Chillicothe, OH 45601 +1-888-311-4278 ~25.47 miles northwest of 45621
  • Mid-scale Highway property
  • Hotel has 99 rooms
From$80
Very good 4.0 /5 Latest Reviews Call BookMore Details
Fairfield Inn and Suites by Marriott Chillicothe - Chillicothe
+1-888-469-4795
300 North Plaza Blvd., Chillicothe, OH 45601 +1-888-469-4795 ~25.49 miles northwest of 45621
  • Three Star hotel
  • Hotel has 33 suites
From$125
Very good 4.0 /5 Guest Reviews Call BookMore Details
Hampton Inn & Suites Chillicothe in Chillicothe
+1-888-734-9421
100 North Plaza Blvd., Chillicothe, OH 45601 +1-888-734-9421 ~25.62 miles northwest of 45621
  • Three Star Rural property
  • Hotel has 3 meeting rooms
From$135
Very good 4.0 /5 Latest Reviews Call BookMore Details
Best Western Adena Inn : 1250 North Bridge St.
+1-888-841-5292
1250 North Bridge St., Chillicothe, OH 45601 +1-888-841-5292 ~25.92 miles northwest of 45621
  • Economical Downtown hotel
  • Free breakfast
From$92
Very good 4.0 /5 Guest Reviews Call BookMore Details
Travelodge by Wyndham Gallipolis
+1-888-455-5160
260 Jackson Pike, Gallipolis, OH 45631 +1-888-455-5160 ~27.40 miles southeast of 45621
  • Low priced Rural property
  • 2 floors in property
From$53
Average 3.0 /5 Guest Reviews Call BookMore Details
Quality Inn & Suites in Portsmouth
+1-888-965-8297
5100 Scioto Trail, Portsmouth, OH 45662 +1-888-965-8297 ~29.71 miles southwest of 45621
  • 2-star property
  • Fitness + Health Center
From$60
Very good 4.0 /5 Latest Reviews Call BookMore Details
Quality Inn
+1-888-906-6358
8226 Ohio River Rd., Wheelersburg, OH 45694 +1-888-906-6358 ~29.77 miles southwest of 45621
  • 2-star property
  • 2 floors in hotel
From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Red Roof Inn Portsmouth - Wheelersburg : 8340 Ohio River Rd.
+1-888-749-6785
8340 Ohio River Rd., Wheelersburg, OH 45694 +1-888-749-6785 ~29.98 miles southwest of 45621
  • Economical Highway hotel
  • Check-in: 3:00 PM
From$71
Very good 4.0 /5 Guest Reviews Call BookMore Details
Super 8 by Wyndham Portsmouth
+1-888-878-9982
4266 Us Route 23 North, Portsmouth, OH 45622 +1-888-878-9982 ~29.99 miles southwest of 45621
  • Cheap Rural hotel
  • 3 floors in hotel
From$54
Average 3.0 /5 Guest Reviews Call BookMore Details
Rodeway Inn & Suites
+1-888-389-4485
3762 Us Highway 23, Portsmouth, OH 45662 +1-888-389-4485 ~30.33 miles southwest of 45621
  • Cheap property
  • Check in time: 1400
Ohio University Inn & Conference Center
+1-888-389-4121
331 Richland Ave., Athens, OH 45701 +1-888-389-4121 ~30.56 miles east of 45621
  • 3-star Suburban hotel
  • Check in: 3:00 PM
From$99
Very good 4.0 /5 Guest Reviews Call BookMore Details
Holiday Inn Express Logan An Ihg Hotel : 12916 Grey St.
+1-888-675-2083
12916 Grey St., Logan, OH 43138 +1-888-675-2083 ~30.82 miles north of 45621
  • Midscale Rural property
  • 3 floors in hotel
From$99
Very good 4.0 /5 Read Reviews Call BookMore Details
Sleep Inn Logan Ohio-Hocking Hills - Logan
+1-800-716-8490
12830 Grey St., Logan, OH 43138 +1-800-716-8490 ~30.96 miles north of 45621
  • Economical property
  • 39 sleeping rooms in hotel
From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Baymont by Wyndham Logan in Logan
+1-800-805-5223
12819 Oh 664, Logan, OH 43138 +1-800-805-5223 ~31.09 miles north of 45621
  • Three Star Rural hotel
  • 58 sleeping rooms in hotel
From$80
Average 3.0 /5 Reviews Call BookMore Details
Quality Inn - Gallipolis
+1-888-965-1860
577 State Route 7n, Gallipolis, OH 45631 +1-888-965-1860 ~31.17 miles southeast of 45621
  • Three Star property
  • Hotel has 2 floors
From$66
Average 3.0 /5 Reviews Call BookMore Details
Hampton Inn Gallipolis
+1-888-788-5576
444 State Route 7 South, Gallipolis, OH 45631 +1-888-788-5576 ~31.26 miles southeast of 45621
  • 3-star Rural property
  • Check-in: 3:00 PM
From$105
Very good 4.0 /5 Latest Reviews Call BookMore Details
Super 8 Gallipolis / Pt Pleasant
+1-888-897-9207
321 Upper River Rd., Gallipolis, OH 45631 +1-888-897-9207 ~31.32 miles southeast of 45621
  • Low-priced Highway hotel
  • Free complimentary breakfast
From$59
Average 3.0 /5 Reviews Call BookMore Details
Days Inn by Wyndham Athens
+1-888-311-4278
330 Columbus Rd., Athens, OH 45701 +1-888-311-4278 ~31.91 miles northeast of 45621
  • Low Cost Rural hotel
  • Fitness center on property
Quality Inn in Athens
+1-888-469-4795
20 Home St., Athens, OH 45701 +1-888-469-4795 ~32.20 miles east of 45621
  • 3-star Rural property
  • Hotel has 2 floors
From$80
Very good 4.0 /5 Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites Athens, an IHG Hotel
+1-888-734-9421
555 East State St., Athens, OH 45701 +1-888-734-9421 ~32.49 miles east of 45621
  • Mid-scale Downtown property
  • Hotel has an eco-friendly policy See policy
From$75
Very good 4.0 /5 Guest Reviews Call BookMore Details
Fairfield Inn & Suites Athens
+1-888-841-5292
924 East State St., Athens, OH 45701 +1-888-841-5292 ~32.90 miles east of 45621
  • Three Star Rural hotel
  • Hotel has an eco-friendly policy Read more
From$169
Very good 4.0 /5 Guest Reviews Call BookMore Details
Knights Inn Athens
+1-888-455-5160
997 East State St., Athens, OH 45701 +1-888-455-5160 ~33.51 miles east of 45621
  • 2-star Rural hotel
  • Hotel has an eco-friendly policy Read more
Holiday Inn Portsmouth Downtown, an IHG Hotel in Portsmouth
+1-888-965-8297
711 2nd St., Portsmouth, OH 45662 +1-888-965-8297 ~33.57 miles southwest of 45621
  • Affordable Downtown property
  • Check-in: 3:00pm
From$107
Very good 4.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Athens
+1-888-906-6358
2091 East State St., Athens, OH 45701 +1-888-906-6358 ~34.55 miles east of 45621
  • Two star property
  • 53 rooms in hotel
From$60
Average 3.0 /5 Latest Reviews Call BookMore Details
Quality Inn & Suites - Circleville
+1-888-749-6785
24517 Us Highway 23s, Circleville, OH 43113 +1-888-749-6785 ~36.60 miles northwest of 45621
  • Two star Rural hotel
  • 2 floors in hotel
From$89
Average 3.0 /5 Read Reviews Call BookMore Details
Hampton Inn Circleville - Circleville
+1-888-878-9982
1520 South Court St., Circleville, OH 45113 +1-888-878-9982 ~37.03 miles northwest of 45621
  • Midscale hotel
  • 87 rooms in hotel
From$90
Very good 4.0 /5 Guest Reviews Call BookMore Details
Holiday Inn Express & Suites Circleville An Ihg Hotel - Circleville
+1-888-389-4485
23911 Us 23, Circleville, OH 43113 +1-888-389-4485 ~37.19 miles northwest of 45621
  • Affordable Rural property
  • 2 meeting rooms in property
From$80
Average 3.0 /5 Read Reviews Call BookMore Details
Rodeway Inn
+1-888-389-4121
23897 Us Route 23 South, Circleville, OH 43113 +1-888-389-4121 ~37.23 miles northwest of 45621
  • Cheap hotel
  • Check in time: 03:00pm
Holiday Inn Express & Suites Ironton An Ihg Hotel in Ironton
+1-888-675-2083
401 South 9th St., Ironton, OH 45638 +1-888-675-2083 ~40.03 miles south of 45621
  • Mid-scale Suburban property
  • 3 floors in property
From$85
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Towneplace Suites by Marriott Ironton
+1-800-716-8490
802 Washington St., Ironton, OH 45638 +1-800-716-8490 ~40.06 miles south of 45621
  • 4 star Downtown hotel
  • Check-in: 3:00
Shawnee Lodge & Conference Center in West Portsmouth
+1-800-805-5223
4404b State Route 125, West Portsmouth, OH 45663 +1-800-805-5223 ~40.96 miles southwest of 45621
  • Three Star Rural hotel
  • Gym is available on property
From$59
Average 3.0 /5 Recent Reviews Call BookMore Details
Burr Oak Lodge & Conference Center
+1-888-965-1860
10660 Burr Oak Lodge Rd., Glouster, OH 45732 +1-888-965-1860 ~42.21 miles northeast of 45621
  • Expensive hotel
  • Hotel has 2 floors
From$69
Very good 4.0 /5 Recent Reviews Call BookMore Details
Best Western River Cities in Ashland
+1-888-788-5576
31 Russell Plaza Dr., Ashland, KY 41101 +1-888-788-5576 ~42.64 miles south of 45621
  • Mid-scale Downtown property
  • Access to gym on-site
From$89
Very good 4.0 /5 Latest Reviews Call BookMore Details
Hampton Inn Lancaster
+1-888-897-9207
2041 Schorrway Dr., Lancaster, OH 43130 +1-888-897-9207 ~42.91 miles north of 45621
  • 3-star Suburban property
  • Complimentary breakfast is offered
From$79
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites
+1-888-311-4278
1861 Riverway Dr., Lancaster, OH 43130 +1-888-311-4278 ~42.97 miles north of 45621
  • 3 star hotel
  • Check-in time: 4:00 pm
From$119
Very good 4.0 /5 Recent Reviews Call BookMore Details
Baymont by Wyndham Lancaster : 1721 River Valley Circle North
+1-888-469-4795
1721 River Valley Circle North, Lancaster, OH 43130 +1-888-469-4795 ~43.00 miles north of 45621
  • Economical property
  • Check-in: 12:00 PM
From$60
Very good 4.0 /5 Read Reviews Call BookMore Details
Delta Hotels by Marriott Ashland Downtown in Ashland
+1-888-734-9421
1441 Winchester Ave., Ashland, KY 41101 +1-888-734-9421 ~43.80 miles south of 45621
  • 4 star Downtown property
  • 10 floors in hotel
From$75
Average 3.0 /5 Latest Reviews Call BookMore Details
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