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49221 Hotels/Accommodations

Super 8 - Adrian
+1-888-389-4121
1091 West Us 223, Adrian, MI 49221
  • Two star Downtown property
  • Hotel has a green policy See more
From$39
Average 3.0 /5 Hotel Reviews Call BookMore Details
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Travelodge by Wyndham Adrian - Adrian
+1-888-675-2083
1575 West Maumee St., Adrian, MI 49221
  • Economy Suburban property
From$60
Very Good 4.0 /5 Review Score Call BookMore Details
Carlton Lodge Adrian - Adrian
+1-800-716-8490
1629 West Maumee St., Adrian, MI 49221
  • Midscale Rural hotel
  • Hotel has 14 suites
From$64
Average 3.5 /5 Hotel Reviews Call BookMore Details
Comfort Inn & Suites Adrian
+1-800-805-5223
425 Industrial Dr., Adrian, MI 49221
  • Midscale hotel
From$69
Average 3.0 /5 Latest Reviews Call BookMore Details
Hampton Inn & Amp Suites Adrian : 1335 South Main St.
+1-888-965-1860
1335 South Main St., Adrian, MI 49221
  • Three Star hotel
  • Check in time: 15:00
From$90
Average 3.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Adrian : 1091 Us Highway 223
+1-888-788-5576
1091 Us Highway 223, Adrian, MI 49221
  • Low-priced Downtown hotel
  • Check in time: 3:00 pm
From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Holiday Inn Express Adrian, an IHG Hotel : 1077 East Us Highway 223
+1-888-897-9207
1077 East Us Highway 223, Adrian, MI 49221
  • Mid-scale Rural property
  • Hotel has a green policy Learn more
From$129
Very Good 4.0 /5 Reviews Call BookMore Details
Super 8 by Wyndham Brooklyn
+1-888-311-4278
419 South Main / M50, Brooklyn, MI 49230 ~16.07 miles northwest of 49221
  • Low priced hotel
From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Hampton Inn & Suites
+1-888-469-4795
401 Powell Dr., Dundee, MI 48131 ~20.18 miles east of 49221
  • Three Star Rural property
  • 93 sleeping rooms in hotel
From$80
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Country Inn & Suites by Radisson, Dundee, MI - Dundee
+1-888-734-9421
665 Tecumseh, Dundee, MI 48131 ~20.24 miles east of 49221
  • 3 star Rural hotel
  • Hotel has 3 floors
From$81
Very Good 4.0 /5 Read Reviews Call BookMore Details
Dundee : 102 Whitetail Dr.
+1-888-841-5292
102 Whitetail Dr., Dundee, MI 48131 ~20.34 miles east of 49221
  • Mid-scale Highway property
  • 40 suites in property
From$82
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Quality Inn - Dundee
+1-888-455-5160
111 Waterstradt Commerce Dr., Dundee, MI 48131 ~20.35 miles east of 49221
  • Cheap Rural hotel
  • Complimentary breakfast is offered
From$49
Average 3.0 /5 Read Reviews Call BookMore Details
American Inn & Suites Dundee in Dundee
+1-888-965-8297
130 Outer Dr., Dundee, MI 48131 ~20.52 miles east of 49221
  • Three Star Highway hotel
  • 61 rooms in hotel
From$80
Average 3.0 /5 Read Reviews Call BookMore Details
Days Inn by Wyndham Wauseon - Wauseon
+1-888-906-6358
8319 Oh 108, Wauseon, OH 43567 ~22.24 miles south of 49221
  • Low priced Rural property
  • 48 rooms in hotel
From$48
Average 3.5 /5 Read Reviews Call BookMore Details
M Star Hotel Wauseon : 8225 State Rd. 108
+1-888-749-6785
8225 State Rd. 108, Wauseon, OH 43567 ~22.29 miles south of 49221
  • Mid-scale hotel
  • 35 rooms in hotel
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Rodeway Inn
+1-888-878-9982
8224 State Route 108, Wauseon, OH 43567 ~22.30 miles south of 49221
  • Low-priced Highway hotel
From$45
Average 3.0 /5 Guest Reviews Call BookMore Details
Holiday Inn Express & Suites Wauseon, an IHG Hotel
+1-888-389-4485
8135 State Route 108, Wauseon, OH 43567 ~22.41 miles south of 49221
  • 3 star hotel
  • 15 suites in property
From$100
Average 3.0 /5 Reviews Call BookMore Details
Wingate by Wyndham Sylvania / Toledo - Sylvania
+1-888-389-4121
5480 South Main St., Sylvania, OH 43560 ~22.94 miles southeast of 49221
  • Three Star Suburban property
  • Gym / Fitness Center Available
From$88
Very Good 4.0 /5 Reviews Call BookMore Details
Baymont by Wyndham Milan in Milan
+1-888-675-2083
1230 Dexter St., Milan, MI 48160 ~23.81 miles northeast of 49221
  • Two-star Suburban hotel
  • Comp. Breakfast
From$55
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Hampton Inn Saline
+1-800-716-8490
1250 East Michigan Ave., Saline, MI 48176 ~24.20 miles northeast of 49221
  • Affordable Highway property
  • Free breakfast available
From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Baymont Inn & Suites by Wyndham Swanton/Toledo Airport
+1-800-805-5223
10753 Airport Highway, Swanrton, OH 43558 ~25.44 miles southeast of 49221
  • Two-star hotel
  • Check in: 11:00 AM
From$59
Average 3.0 /5 Recent Reviews Call BookMore Details
Comfort Inn Chelsea
+1-888-965-1860
1645 Commerce Park Dr., Chelsea, MI 48118 ~27.06 miles north of 49221
  • 3-star Highway property
  • 10 conference rooms in property
From$83
Average 3.0 /5 Reviews Call BookMore Details
Baymont by Wyndham Chelsea : 1540 Commerce Park Dr.
+1-888-788-5576
1540 Commerce Park Dr., Chelsea, MI 48118 ~27.14 miles north of 49221
  • 3 star Highway property
  • Free comp. breakfast
From$69
Average 3.0 /5 Read Reviews Call BookMore Details
Red Roof Inn Toledo - University in Toledo
+1-888-897-9207
3530 Executive Pkwy., Toledo, OH 43606 ~27.50 miles southeast of 49221
  • 2-star Downtown hotel
  • Check in time: 2:00pm
From$46
Average 3.0 /5 Review Score Call BookMore Details
Quality Inn Toledo - Toledo
+1-888-311-4278
3560 Secor Rd., Toledo, OH 43606 Website ~27.58 miles southeast of 49221
  • 2-star property
  • Free breakfast available
Residence Inn Toledo Marriott in Toledo
+1-888-469-4795
3554 Secor Rd., Toledo, OH 43606 ~27.59 miles southeast of 49221
  • 3-star hotel
  • Hotel has 110 suites
From$90
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Courtyard Toledo West - Toledo
+1-888-734-9421
3536 Secor Rd., Toledo, OH 43606 ~27.59 miles southeast of 49221
  • Three Star Suburban hotel
  • 118 rooms in property
From$99
Average 3.0 /5 Review Score Call BookMore Details
Econo Lodge Airport - Holland - Holland
+1-888-841-5292
1201 East Mall Dr., Holland, OH 43528 ~27.61 miles southeast of 49221
  • Cheap Suburban hotel
  • Check in time: 1:00 PM
Holiday Inn Express & Suites Toledo West, an IHG Hotel - Toledo
+1-888-455-5160
3440 Secor Rd., Toledo, OH 43606 ~27.65 miles southeast of 49221
  • Midscale Suburban hotel
  • Has environment-friendly policy See more
From$109
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Hampton Inn & Suites Toledo/Westgate - Toledo
+1-888-965-8297
3434 Secor Rd., Toledo, OH 43606 ~27.68 miles southeast of 49221
  • Mid-scale Suburban property
  • 111 rooms in property
From$119
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Red Roof Inn Toledo - Holland
+1-888-906-6358
1214 Corporate Dr., Holland, OH 43528 ~27.80 miles southeast of 49221
  • Two-star Suburban hotel
  • Hotel has 106 rooms
Quality Inn Toledo Airport in Holland
+1-888-749-6785
1401 East Mall Dr., Holland, OH 43528 ~27.87 miles southeast of 49221
  • 2 star Airport property
  • 3 floors in property
From$49
Average 3.0 /5 Read Reviews Call BookMore Details
Motel 6 Ann Arbor : 3764 South State St.
+1-888-878-9982
3764 South State St., Ann Arbor, MI 48108 ~27.88 miles northeast of 49221
  • 2-star property
  • Check in time: 15:00
From$46
Average 3.0 /5 Reviews Call BookMore Details
Toledo Holland Courtyard Marriott - Holland
+1-888-389-4485
1435 East Mall Dr., Holland, OH 43528 ~27.90 miles southeast of 49221
  • Affordable Suburban property
  • 12 suites in property
From$89
Very Good 4.0 /5 Read Reviews Call BookMore Details
Staybridge Suites Ann Arbor Univ of Michigan An Ihg Hotel : 3850 Research Park Dr.
+1-888-389-4121
3850 Research Park Dr., Ann Arbor, MI 48108 ~27.90 miles northeast of 49221
  • Affordable Highway hotel
  • Has environment-friendly policy Read more
From$119
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Towneplace Suites by Marriott Ann Arbor : 1301 Briarwood Circle Dr.
+1-888-675-2083
1301 Briarwood Circle Dr., Ann Arbor, MI 48108 ~27.95 miles northeast of 49221
  • Low-priced Golf Course property
  • Fitness center on property
From$150
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Holiday Inn Exp Stes University Sou
+1-800-716-8490
3853 Research Park Dr., Ann Arbor, MI 48108 ~27.99 miles northeast of 49221
  • Three Star property
  • Check-in: 15:00
From$90
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Hilton Garden Inn Ann Arbor in Ann Arbor
+1-800-805-5223
1401 Briarwood Circle, Ann Arbor, MI 48108 ~28.00 miles northeast of 49221
  • Affordable Highway hotel
  • Hotel has 5 meeting rooms
From$119
Very Good 4.0 /5 Reviews Call BookMore Details
Sonesta Simply Suites Detroit Ann Arbor
+1-888-965-1860
701 Waymarket Way, Ann Arbor, MI 48103 ~28.03 miles northeast of 49221
  • Three Star Suburban hotel
  • Check-in time: 3:00 PM
From$66
Very Good 4.0 /5 Review Score Call BookMore Details
Extended Stay America Suites Toledo Holland
+1-888-788-5576
6155 Trust Dr., Holland, OH 43528 ~28.06 miles southeast of 49221
  • Affordable Suburban hotel
  • Hotel has 3 floors
From$53
Average 3.0 /5 Hotel Reviews Call BookMore Details
Hawthorn Suites by Wyndham Holland/Toledo Area in Holland
+1-888-897-9207
6101 Trust Dr., Holland, OH 43528 ~28.10 miles southeast of 49221
  • 3 star Airport hotel
  • Check-in: 3:00PM
From$45
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Even Hotels Ann Arbor An Ihg Hotel in Ann Arbor
+1-888-311-4278
600 Briarwood Circle, Ann Arbor, MI 48108 ~28.14 miles northeast of 49221
  • 3 star Suburban property
  • 107 rooms in hotel
From$99
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Knights Inn Maumee - Maumee
+1-888-469-4795
1520 South Holland Sylvania Rd., Maumee, OH 43537 ~28.26 miles southeast of 49221
  • Mid-scale Highway hotel
  • Free complimentary breakfast
From$32
Average 3.0 /5 Latest Reviews Call BookMore Details
The Kensington Hotel in Ann Arbor
+1-888-734-9421
3500 South State St., Ann Arbor, MI 48108 ~28.27 miles northeast of 49221
  • Three Star Suburban hotel
  • 3 suites in property
From$104
Very Good 4.0 /5 Review Score Call BookMore Details
Knights Inn Maumee - Maumee
+1-888-841-5292
1520s Holland Sylvania Rd., Maumee, OH 43537 ~28.27 miles southeast of 49221
  • Economical Highway property
  • Free complimentary breakfast
From$42
Average 3.0 /5 Latest Reviews Call BookMore Details
Red Roof Inn Ann Arbor - University of Michigan South : 3505 South State St.
+1-888-455-5160
3505 South State St., Ann Arbor, MI 48108 ~28.33 miles northeast of 49221
  • 2-star Downtown property
  • Comp. Breakfast
From$29
Average 3.0 /5 Hotel Reviews Call BookMore Details
Comfort Inn & Suites University South
+1-888-965-8297
3501 South State, Ann Arbor, MI 48108 ~28.33 miles northeast of 49221
  • Two star Suburban hotel
  • 3 floors in property
From$67
Average 3.0 /5 Recent Reviews Call BookMore Details
Sonesta Es Suites Ann Arbor
+1-888-906-6358
800 Victors Way, Ann Arbor, MI 48108 ~28.37 miles northeast of 49221
  • 3-star Highway hotel
  • Hotel has 114 rooms
From$99
Very Good 4.0 /5 Read Reviews Call BookMore Details
Hyatt Place Ann Arbor - Ann Arbor
+1-888-749-6785
3223 South State St., Ann Arbor, MI 48108 ~28.42 miles northeast of 49221
  • 3-star Downtown hotel
  • Hotel has 6 floors
From$99
Average 3.0 /5 Guest Reviews Call BookMore Details
Sheraton Ann Arbor Hotel
+1-888-878-9982
3200 Boardwalk, Ann Arbor, MI 48108 ~28.43 miles northeast of 49221
  • 3-star Suburban hotel
  • 196 sleeping rooms in hotel
From$109
Very Good 4.0 /5 Latest Reviews Call BookMore Details

Next: Show All Available 49221 Hotels with Pricing

Graph: Next 20 Days of Adrian Hotel Prices

Rates shown are nightly rates before taxes and do not necessarily reflect all Adrian, MI discounts available. The chart reflects the cheapest Adrian hotel for each day and each star rating category.

FAQs about hotels near 49221

What are the most favored hotels near 49221?

Travelodge by Wyndham Adrian, Holiday Inn Express Adrian, an IHG Hotel and Hampton Inn & Suites are the best rated hotels based on customer reviews in the last 365 days.

What are the most high-end hotels near 49221?

Carlton Lodge Adrian, Comfort Inn & Suites Adrian and Hampton Inn & Amp Suites Adrian are the top 3 luxury hotels near 49221.

What hotels are closest to the area of 49221?

Super 8, Travelodge by Wyndham Adrian, and Carlton Lodge Adrian are the properties closest to 49221.

How much does a cheap hotel near 49221 cost per night?

In the last year, a 2 star hotel near 49221 can be as cheap as $54.93 per night. (based on HotelPlanner prices)

How much does a 3 star hotel near 49221 cost per night?

In the last year, the average 3 star hotel near 49221 has been $112.99 per night. (based on HotelPlanner prices)

What are the most popular independent hotels near 49221?

Dundee, Even Hotels Ann Arbor An Ihg Hotel and The Kensington Hotel are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels near 49221?

Residence Inn Toledo Marriott, Toledo Holland Courtyard Marriott and Towneplace Suites by Marriott Ann Arbor are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the most popular Choice Hotels branded hotels near 49221?

Quality Inn, Rodeway Inn and Comfort Inn Chelsea are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the most popular IHG hotels near 49221?

Holiday Inn Express Adrian, an IHG Hotel, Holiday Inn Express & Suites Toledo West, an IHG Hotel and Staybridge Suites Ann Arbor Univ of Michigan An Ihg Hotel are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

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