Charleston Missouri Hotels & Motels

Find the perfect hotel in Charleston using our hotel guide provided below. Find discounted hotel accommodations in or close to Charleston, MO for your upcoming individual or group travel. Discover the most popular Charleston, Missouri hotel and motel rooms. Browse the Charleston area hotels to find the perfect lodging! Please use the provided map of the Charleston hotels. Coordinating a group? Get Charleston Group Hotel Rates

Charleston Hotels, Motels & Accommodations

Super 8 by Wyndham Charleston/Sikeston East MO in Charleston
+1-888-389-4121

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New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
310 South Story, Charleston, MO 63834 +1-888-389-4121
  • Low-priced Highway property
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From£33
Average 3.5 /5 Guest Reviews Call BookMore Details
Quality Inn Charleston - Sikeston in Charleston
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
102 Drake St., Charleston, MO 63834 +1-888-675-2083
  • Economy Highway property
  • Gym / Fitness Center Available
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From£46
Average 3.0 /5 Latest Reviews Call BookMore Details
Motel 6 Sikeston Mo : 110 South Interstate Dr.
+1-800-716-8490

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New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
110 South Interstate Dr., SIKESTON, MO 63801 +1-800-716-8490 ~11.02 miles west of Charleston
  • Low Cost hotel
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From£47
Average 3.0 /5 Latest Reviews Call BookMore Details
Best Western Plus Sikeston : 120 South Interstate Dr.
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
120 South Interstate Dr., Sikeston, MO 63801 +1-800-805-5223 ~11.05 miles west of Charleston
  • Two star Highway hotel
  • Check-in: 03:00
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From£34
Very good 4.0 /5 Guest Reviews Call BookMore Details
Days Inn and Suites by Wyndham Sikeston
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
220 South Interstate Dr., Sikeston, MO 63801 +1-888-965-1860 ~11.09 miles west of Charleston
  • Cheap hotel
  • Check-in: 03:00 PM
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From£47
Average 3.0 /5 Recent Reviews Call BookMore Details
Quality Inn Cairo I-57 : 13201 Kessler Rd.
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
13201 Kessler Rd., Cairo, IL 62914 +1-888-788-5576 ~11.20 miles northeast of Charleston
  • Three Star Highway property
  • Hotel has 2 floors
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From£47
Poor 2.0 /5 Review Score Call BookMore Details
Super 8 by Wyndham Sikeston/Miner Area
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
2609 East Malone, Sikeston, MO 63801 +1-888-897-9207 ~11.36 miles west of Charleston
  • 2 star Convention Center hotel
  • Free breakfast
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From£47
Average 3.0 /5 Latest Reviews Call BookMore Details
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) - Sikeston
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
100 Matthews Lane, Sikeston, MO 63801 +1-888-311-4278 ~11.37 miles west of Charleston
  • Midscale Highway property
  • 40 sleeping rooms in hotel
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From£63
Very good 4.0 /5 Reviews Call BookMore Details
Comfort Inn
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
109 Matthews Lane, Sikeston, MO 63801 +1-888-469-4795 ~11.40 miles west of Charleston
  • 3 star Highway property
  • Hotel has 64 rooms
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From£67
Average 3.0 /5 Reviews Call BookMore Details
Drury Inn & Suites Sikeston
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
2608 East Malone Ave., Sikeston, MO 63801 +1-888-734-9421 ~11.45 miles west of Charleston
  • Affordable Highway property
  • 154 rooms in hotel
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From£82
Very good 4.5 /5 Recent Reviews Call BookMore Details
Pear Tree Inn Sikeston
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
2602 East Malone, Sikeston, MO 63801 +1-888-841-5292 ~11.45 miles west of Charleston
  • 3 star Suburban property
  • Hotel has an eco-friendly policy See policy
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From£63
Average 3.0 /5 Guest Reviews Call BookMore Details
Hampton Inn Sikeston - Sikeston
+1-888-455-5160

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New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
1240 Commerce Dr., Sikeston, MO 63801 +1-888-455-5160 ~14.31 miles west of Charleston
  • Affordable Rural hotel
  • Hotel has 92 rooms
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From£63
Average 3.0 /5 Latest Reviews Call BookMore Details
Holiday Inn Express & Suites Sikeston An Ihg Hotel in Sikeston
+1-888-965-8297

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New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
115 Hospitality Dr., Sikeston, MO 63801 +1-888-965-8297 ~14.33 miles west of Charleston
  • Affordable Rural hotel
  • 3 floors in property
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From£63
Average 3.0 /5 Latest Reviews Call BookMore Details
Americas Best Value Inn Ullin Mounds
+1-888-906-6358

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New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
128 Cheekwood Lane, Ullin, IL 62992 +1-888-906-6358 ~25.98 miles north of Charleston
  • Two star property
  • Check-in time: 15:00
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From£47
Average 3.0 /5 Hotel Reviews Call BookMore Details
Courtyard by Marriott Cape Girardeau Downtown - Cape Girardeau
+1-888-749-6785

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New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
400 Broadway St., Cape Girardeau, MO 63701 +1-888-749-6785 ~28.56 miles north of Charleston
  • Midscale Downtown property
  • Hotel has 5 floors
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From£63
Very good 4.0 /5 Review Score Call BookMore Details
Candlewood Suites Cape Girardeau, an IHG Hotel : 485 South Mount Auburn Rd.
+1-888-878-9982

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New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
485 South Mount Auburn Rd., Cape Girardeau, MO 65703 +1-888-878-9982 ~28.61 miles northwest of Charleston
  • 2 star Highway property
  • 85 sleeping rooms in hotel
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From£54
Very good 4.0 /5 Reviews Call BookMore Details
Hampton Inn Cape Girardeau I 55 East in Cape Girardeau
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
207 South Mount Auburn Rd., Cape Girardeau, MO 63703 +1-888-389-4485 ~29.33 miles northwest of Charleston
  • 3-star Highway hotel
  • Hotel has 86 rooms
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From£63
Excellent 5.0 /5 Guest Reviews Call BookMore Details
Victorian Inn & Suites
+1-888-389-4121

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New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
3256 William St., Cape Girardeau, MO 63703 +1-888-389-4121 ~29.40 miles northwest of Charleston
  • Midscale Golf Course hotel
  • 133 rooms in hotel
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From£62
Average 3.0 /5 Read Reviews Call BookMore Details
Auburn Place Hotel & Suites
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
3265 Williams St., Cape Girardeau, MO 63702 +1-888-675-2083 ~29.41 miles northwest of Charleston
  • 3-star Highway hotel
  • Free complimentary breakfast
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From£46
Very good 4.5 /5 Recent Reviews Call BookMore Details
Holiday Inn Express & Suites Cape Girardeau I 55 - Cape Girardeau
+1-800-716-8490

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New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
3253 William St., Cape Girardeau, MO 63701 +1-800-716-8490 ~29.43 miles northwest of Charleston
  • Midscale property
  • 102 rooms in hotel
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From£63
Very good 4.5 /5 Reviews Call BookMore Details
Fairfield Inn & Suites Cape Girardeau - Cape Girardeay
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
433 Cape West Crossing, Cape Girardeay, MO 63703 +1-800-805-5223 ~29.46 miles northwest of Charleston
  • Mid-scale property
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From£63
Average 3.0 /5 Read Reviews Call BookMore Details
Pear Tree Inn Cape Girardeau West
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
103 Cape West Pkwy., Cape Girardeau, MO 63701 +1-888-965-1860 ~29.49 miles northwest of Charleston
  • Low priced property
  • 2 suites in property
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From£46
Average 3.0 /5 Review Score Call BookMore Details
Pear Tree Inn Cape Girardeau Medical Center in Cape Girardeau
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
3248 William St., Cape Girardeau, MO 63701 +1-888-788-5576 ~29.50 miles northwest of Charleston
  • Cheap Highway hotel
  • Comp. Breakfast
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From£52
Very good 4.0 /5 Guest Reviews Call BookMore Details
Drury Suites Cape Girardeau
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
3303 Campster Dr., Cape Girardeau, MO 63701 +1-888-897-9207 ~29.60 miles northwest of Charleston
  • Midscale Highway hotel
  • Hotel has 5 floors
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From£67
Very good 4.5 /5 Hotel Reviews Call BookMore Details
Drury Lodge
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
104 South Vantage Dr., Cape Girardeau, MO 63701 +1-888-311-4278 ~29.77 miles northwest of Charleston
  • Mid-scale Highway hotel
  • Fitness / Gym is on-site
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From£63
Average 3.0 /5 Hotel Reviews Call BookMore Details
Drury Plaza Hotel & Conference Center Cape Girardeau - Cape Girardeau
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
3351 Percy Dr., Cape Girardeau, MO 63701 +1-888-469-4795 ~29.79 miles northwest of Charleston
  • 3 star hotel
  • Hotel has an eco-friendly policy Learn more
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From£46
Average 3.0 /5 Reviews Call BookMore Details
Travel Inn : 301 Route Ad
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
301 Route Ad, Marston, MO 63866 +1-888-734-9421 ~31.28 miles southwest of Charleston
  • Economy Highway hotel
  • Free complimentary breakfast
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From£31
Poor 2.5 /5 Review Score Call BookMore Details
Travel Inn in Martson
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
301 State Highway Ad, Martson, MO 63866 +1-888-841-5292 ~31.46 miles southwest of Charleston
  • Cheap property
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From£47
Poor 2.5 /5 Latest Reviews Call BookMore Details
Red Roof Inn Marston
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
501 South Outer Rd., Marston, MO 63866 +1-888-455-5160 ~31.61 miles southwest of Charleston
  • Economical property
  • 63 sleeping rooms in hotel
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From£47
Average 3.0 /5 Hotel Reviews Call BookMore Details
Quality Inn : 2011 North Kingshighway St.
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
2011 North Kingshighway St., Cape Girardeau, MO 63701 Website +1-888-965-8297 ~31.73 miles northwest of Charleston
  • Cheap hotel
  • 49 rooms in property
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From£47
Very good 4.0 /5 Latest Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Jackson / Cape Girardeau - Jackson
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
3003 South Old Orchard Rd., Jackson, MO 63755 +1-888-906-6358 ~33.46 miles northwest of Charleston
  • Midscale Highway hotel
  • 4 floors in property
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From£67
Very good 4.0 /5 Review Score Call BookMore Details
Comfort Suites Jackson-Cape Girardeau in Jackson
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
2904 Old Orchard Rd., Jackson, MO 63755 Website +1-888-749-6785 ~33.57 miles northwest of Charleston
  • 3-star Highway hotel
  • 3 floors in property
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From£51
Average 3.0 /5 Hotel Reviews Call BookMore Details
Comfort Suites
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
2904 Old Orchard Rd., Jackson, 63755 United States +1-888-878-9982 ~33.57 miles northwest of Charleston
  • 4 star Highway hotel
  • Check in: 3:00 PM
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From£99
Average 3.0 /5 Hotel Reviews Call BookMore Details
Residence Inn by Marriott Paducah : 3900 Coleman Crossing Circle
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
3900 Coleman Crossing Circle, Paducah, KY 42001 +1-888-389-4485 ~34.97 miles east of Charleston
  • Mid-scale Suburban property
  • Comp. Breakfast
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From£70
Very good 4.0 /5 Recent Reviews Call BookMore Details
Pear Tree Inn Paducah
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
5006 Hinkleville Rd., Paducah, KY 42001 +1-888-389-4121 ~35.47 miles east of Charleston
  • Cheap Suburban property
  • 59 rooms in property
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From£43
Very good 4.0 /5 Read Reviews Call BookMore Details
Econo Lodge Dexter
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
913 Outer Rd., Dexter, MO 63841 +1-888-675-2083 ~36.12 miles west of Charleston
  • 2 star hotel
  • 38 rooms in hotel
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From£47
Average 3.0 /5 Guest Reviews Call BookMore Details
Harrah's Metropolis Hotel & Casino in Metropolis
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
100 East Front St., Metropolis, IL 62960 +1-800-716-8490 ~36.52 miles east of Charleston
  • Four star hotel
  • Check-in: 16:00
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From£127
Very good 4.0 /5 Review Score Call BookMore Details
Baymont by Wyndham Metropolis
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
203 East Front St., Metropolis, IL 62960 +1-800-805-5223 ~36.55 miles east of Charleston
  • Low-priced Riverfront property
  • 117 rooms in hotel
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From£35
Average 3.0 /5 Read Reviews Call BookMore Details
Sleep Inn & Mainstay Suites in Union City
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
1111 Blue Heron Lane, Union City, TN 38261 +1-888-965-1860 ~36.64 miles southeast of Charleston
  • Cheap Rural property
  • Check-in time: 15:00
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From£47
Average 3.0 /5 Guest Reviews Call BookMore Details
Travelodge by Wyndham Dexter - Dexter
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
1608 West Business U.s. 60, Dexter, MO 63841 +1-888-788-5576 ~36.87 miles west of Charleston
  • Midscale hotel
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From£53
Very good 4.0 /5 Guest Reviews Call BookMore Details
 Econo Lodge Paducah West I-24
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
5120 Hinkleville Rd., Paducah, KY 42001 +1-888-897-9207 ~37.23 miles east of Charleston
  • Low priced Airport property
  • 2 floors in hotel
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From£47
Average 3.0 /5 Read Reviews Call BookMore Details
Drury Suites Paducah
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
2930 James Sanders Blvd., Paducah, KY 42001 +1-888-311-4278 ~37.34 miles east of Charleston
  • Three Star Suburban property
  • 2 conference rooms in property
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From£78
Very good 4.0 /5 Review Score Call BookMore Details
Quality Suites Paducah I-24
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
2880 James Sanders Blvd., Paducah, KY 42001 Website +1-888-469-4795 ~37.41 miles east of Charleston
  • Low Cost Highway property
  • Free comp. breakfast
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From£47
Average 3.0 /5 Guest Reviews Call BookMore Details
Sleep Inn Union City - Union City
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
1111b Blue Heron Lane, Union City, TN 38261 +1-888-734-9421 ~37.44 miles southeast of Charleston
  • Economy Rural hotel
  • Hotel has 40 rooms
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From£61
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Comfort Inn & Suites near Six Flags in Lithia Springs
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
960 West Pointe Court, Lithia Springs, GA 30122 Website +1-888-841-5292 ~37.46 miles east of Charleston
  • 3-star Downtown hotel
  • Fitness / Gym is on-site
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From£55
Very good 4.0 /5 Review Score Call BookMore Details
Country Inn & Suites by Radisson, Paducah, KY - Paducah
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
145 Mcbride Lane, Paducah, KY 42001 +1-888-455-5160 ~37.46 miles east of Charleston
  • Affordable Highway property
  • Hotel has 3 floors
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From£38
Very good 4.0 /5 Reviews Call BookMore Details
Baymont by Wyndham Paducah
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
5300 Old Cairo Rd., Paducah, KY 42001 +1-888-965-8297 ~37.50 miles east of Charleston
  • 3-star property
  • Hotel has 3 floors
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From£31
Poor 2.0 /5 Hotel Reviews Call BookMore Details
Hotel 7 Inn - Paducah
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
5001 Hinkleville Rd., Paducah, KY 42001 +1-888-906-6358 ~37.51 miles east of Charleston
  • Inexpensive property
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From£47
Average 3.0 /5 Reviews Call BookMore Details
Econo Lodge : 1415 East 5th St.
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
1415 East 5th St., Metropolis, IL 62960 +1-888-749-6785 ~37.60 miles east of Charleston
  • Two star hotel
  • Check in time: 11:00
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From£47
Terrible 1.0 /5 Reviews Call BookMore Details
Mainstay Suites : 1111a Blue Heron Lane
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
1111a Blue Heron Lane, Union City, TN 38261 +1-888-878-9982 ~37.65 miles southeast of Charleston
  • Cheap Rural property
  • Hotel has 3 floors
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From£67
Average 3.0 /5 Read Reviews Call BookMore Details

Next: See My Charleston Hotels with Pricing

Recent traveler reviews of Charleston, MO

Below are reviews of the city of Charleston, MO from an actual visitor's perspective.

"Easily Accessible"
Score 5.0 / 5

Easily accessible.

Mamon T., from 07-Dec-2023
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