Charleston Missouri Hotels & Motels

Find the perfect hotel in Charleston using our hotel guide provided below. Find discounted hotel accommodations in or close to Charleston, MO for your upcoming individual or group travel. Discover the most popular Charleston, Missouri hotel and motel rooms. Browse the Charleston area hotels to find the perfect lodging! Please use the provided map of the Charleston hotels. Coordinating a group? Get Charleston Group Hotel Rates

Charleston Hotels/Accommodations

Super 8 by Wyndham Charleston/Sikeston East MO in Charleston
+1-888-389-4121

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New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
310 South Story, Charleston, MO 63834 +1-888-389-4121
  • Two star Highway hotel
  • Free complimentary breakfast
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From£32
Average 3.5 /5 Recent Reviews Call BookMore Details
Quality Inn Charleston - Sikeston
+1-888-675-2083

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New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
102 Drake St., Charleston, MO 63834 +1-888-675-2083
  • 2-star Highway property
  • Fitness / Gym is on-site
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From£45
Average 3.0 /5 Latest Reviews Call BookMore Details
Motel 6 Sikeston Mo : 110 South Interstate Dr.
+1-800-716-8490

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New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
110 South Interstate Dr., SIKESTON, MO 63801 +1-800-716-8490 ~11.02 miles west of Charleston
  • 2 star property
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From£46
Average 3.0 /5 Review Score Call BookMore Details
Best Western Plus Sikeston in Sikeston
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
120 South Interstate Dr., Sikeston, MO 63801 +1-800-805-5223 ~11.05 miles west of Charleston
  • Low priced Highway property
  • 55 rooms in property
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From£33
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Days Inn and Suites by Wyndham Sikeston - Sikeston
+1-888-965-1860

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New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
220 South Interstate Dr., Sikeston, MO 63801 +1-888-965-1860 ~11.09 miles west of Charleston
  • Two-star property
  • Check in: 03:00 PM
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From£46
Average 3.0 /5 Review Score Call BookMore Details
Quality Inn Cairo I-57
+1-888-788-5576

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New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
13201 Kessler Rd., Cairo, IL 62914 +1-888-788-5576 ~11.20 miles northeast of Charleston
  • Affordable Highway property
  • Hotel has 2 floors
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From£46
Poor 2.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Sikeston/Miner Area : 2609 East Malone
+1-888-897-9207

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New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
2609 East Malone, Sikeston, MO 63801 +1-888-897-9207 ~11.36 miles west of Charleston
  • Low-priced Convention Center property
  • Comp. Breakfast
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From£46
Average 3.0 /5 Review Score Call BookMore Details
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
+1-888-311-4278

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New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
100 Matthews Lane, Sikeston, MO 63801 +1-888-311-4278 ~11.37 miles west of Charleston
  • Affordable Highway hotel
  • Complimentary breakfast is offered
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From£61
Very good 4.0 /5 Latest Reviews Call BookMore Details
Comfort Inn
+1-888-469-4795

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New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
109 Matthews Lane, Sikeston, MO 63801 +1-888-469-4795 ~11.40 miles west of Charleston
  • 3 star Highway property
  • Access to gym on-site
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From£65
Average 3.0 /5 Review Score Call BookMore Details
Drury Inn & Suites Sikeston
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
2608 East Malone Ave., Sikeston, MO 63801 +1-888-734-9421 ~11.45 miles west of Charleston
  • Mid-scale Highway property
  • 154 sleeping rooms in hotel
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From£79
Very good 4.5 /5 Reviews Call BookMore Details
Pear Tree Inn Sikeston
+1-888-841-5292

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New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
2602 East Malone, Sikeston, MO 63801 +1-888-841-5292 ~11.45 miles west of Charleston
  • Mid-scale Suburban hotel
  • Hotel has a green policy Read more
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From£61
Average 3.0 /5 Review Score Call BookMore Details
Hampton Inn Sikeston
+1-888-455-5160

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New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
1240 Commerce Dr., Sikeston, MO 63801 +1-888-455-5160 ~14.31 miles west of Charleston
  • 3-star Rural property
  • Comp. Breakfast
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From£61
Average 3.0 /5 Review Score Call BookMore Details
Holiday Inn Express & Suites Sikeston An Ihg Hotel - Sikeston
+1-888-965-8297

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New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
115 Hospitality Dr., Sikeston, MO 63801 +1-888-965-8297 ~14.33 miles west of Charleston
  • 3-star Rural property
  • Gym / Fitness Center Available
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From£61
Average 3.0 /5 Reviews Call BookMore Details
Americas Best Value Inn Ullin Mounds in Ullin
+1-888-906-6358

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New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
128 Cheekwood Lane, Ullin, IL 62992 +1-888-906-6358 ~25.98 miles north of Charleston
  • Two-star property
  • 2 floors in property
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From£46
Average 3.0 /5 Read Reviews Call BookMore Details
Courtyard by Marriott Cape Girardeau Downtown
+1-888-749-6785

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New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
400 Broadway St., Cape Girardeau, MO 63701 +1-888-749-6785 ~28.56 miles north of Charleston
  • 3 star Downtown property
  • Hotel has 78 rooms
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From£61
Very good 4.0 /5 Reviews Call BookMore Details
Candlewood Suites Cape Girardeau by IHG
+1-888-878-9982

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New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
485 South Mount Auburn Rd., Cape Girardeau, MO 65703 +1-888-878-9982 ~28.61 miles northwest of Charleston
  • Cheap Highway property
  • Hotel has 85 suites
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From£53
Very good 4.0 /5 Guest Reviews Call BookMore Details
Hampton Inn Cape Girardeau I 55 East
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
207 South Mount Auburn Rd., Cape Girardeau, MO 63703 +1-888-389-4485 ~29.33 miles northwest of Charleston
  • Mid-scale Highway hotel
  • Free comp. breakfast
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From£61
Excellent 5.0 /5 Latest Reviews Call BookMore Details
Victorian Inn & Suites : 3256 William St.
+1-888-389-4121

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New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
3256 William St., Cape Girardeau, MO 63703 +1-888-389-4121 ~29.40 miles northwest of Charleston
  • Three Star Golf Course hotel
  • Hotel has 133 rooms
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From£60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Auburn Place Hotel & Suites in Cape Girardeau
+1-888-675-2083

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New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
3265 Williams St., Cape Girardeau, MO 63702 +1-888-675-2083 ~29.41 miles northwest of Charleston
  • 3 star Highway hotel
  • Free comp. breakfast
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From£44
Very good 4.5 /5 Review Score Call BookMore Details
Holiday Inn Express & Suites Cape Girardeau I 55 : 3253 William St.
+1-800-716-8490

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New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
3253 William St., Cape Girardeau, MO 63701 +1-800-716-8490 ~29.43 miles northwest of Charleston
  • 3 star hotel
  • 102 suites in property
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From£61
Very good 4.5 /5 Read Reviews Call BookMore Details
Fairfield Inn & Suites Cape Girardeau
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
433 Cape West Crossing, Cape Girardeay, MO 63703 +1-800-805-5223 ~29.46 miles northwest of Charleston
  • Three Star property
  • 22 suites in hotel
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From£61
Average 3.0 /5 Recent Reviews Call BookMore Details
Pear Tree Inn Cape Girardeau West - Cape Girardeau
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
103 Cape West Pkwy., Cape Girardeau, MO 63701 +1-888-965-1860 ~29.49 miles northwest of Charleston
  • 2-star property
  • 81 rooms in property
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From£45
Average 3.0 /5 Recent Reviews Call BookMore Details
Pear Tree Inn Cape Girardeau Medical Center
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
3248 William St., Cape Girardeau, MO 63701 +1-888-788-5576 ~29.50 miles northwest of Charleston
  • 2 star Highway hotel
  • Free breakfast
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From£50
Very good 4.0 /5 Reviews Call BookMore Details
Drury Suites Cape Girardeau
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
3303 Campster Dr., Cape Girardeau, MO 63701 +1-888-897-9207 ~29.60 miles northwest of Charleston
  • Affordable Highway property
  • 5 floors in hotel
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From£65
Very good 4.5 /5 Hotel Reviews Call BookMore Details
Drury Plaza Hotel & Conference Center Cape Girardeau in Cape Girardeau
+1-888-311-4278

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New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
3351 Percy Dr., Cape Girardeau, MO 63701 +1-888-311-4278 ~29.76 miles northwest of Charleston
  • Mid-scale property
  • Free breakfast
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From£45
Average 3.0 /5 Guest Reviews Call BookMore Details
Drury Lodge - Cape Girardeau
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
104 South Vantage Dr., Cape Girardeau, MO 63701 +1-888-469-4795 ~29.77 miles northwest of Charleston
  • 3 star Highway hotel
  • Fitness center on property
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From£61
Average 3.0 /5 Reviews Call BookMore Details
Travel Inn
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
301 Route Ad, Marston, MO 63866 +1-888-734-9421 ~31.28 miles southwest of Charleston
  • Low Cost Highway hotel
  • Hotel has 60 rooms
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From£30
Poor 2.5 /5 Guest Reviews Call BookMore Details
Travel Inn
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
301 State Highway Ad, Martson, MO 63866 +1-888-841-5292 ~31.46 miles southwest of Charleston
  • Economical property
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From£46
Poor 2.5 /5 Guest Reviews Call BookMore Details
Red Roof Inn Marston - Marston
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
501 South Outer Rd., Marston, MO 63866 +1-888-455-5160 ~31.61 miles southwest of Charleston
  • 2 star hotel
  • 63 rooms in hotel
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From£46
Average 3.0 /5 Reviews Call BookMore Details
Quality Inn
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
2011 North Kingshighway St., Cape Girardeau, MO 63701 Website +1-888-965-8297 ~31.73 miles northwest of Charleston
  • Low Cost hotel
  • Hotel has an eco-friendly policy See more
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From£46
Very good 4.0 /5 Reviews Call BookMore Details
TRU by Hilton Cape Girardeau in Cape Girardeau
+1-888-906-6358

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New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
2520 Veterans Memorial Dr., Cape Girardeau, MO 63701 +1-888-906-6358 ~32.92 miles northwest of Charleston
  • Affordable Highway property
  • 4 floors in property
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From£61
Average 3.0 /5 Latest Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Jackson / Cape Girardeau
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
3003 South Old Orchard Rd., Jackson, MO 63755 +1-888-749-6785 ~33.46 miles northwest of Charleston
  • Mid-scale Highway property
  • Hotel has 9 suites
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From£65
Very good 4.0 /5 Reviews Call BookMore Details
Comfort Suites Jackson-Cape Girardeau
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
2904 Old Orchard Rd., Jackson, MO 63755 Website +1-888-878-9982 ~33.57 miles northwest of Charleston
  • Affordable Highway hotel
  • 64 suites in property
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From£49
Average 3.0 /5 Reviews Call BookMore Details
Comfort Suites - Jackson
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
2904 Old Orchard Rd., Jackson, 63755 United States +1-888-389-4485 ~33.57 miles northwest of Charleston
  • Expensive Highway hotel
  • 64 sleeping rooms in hotel
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From£96
Average 3.0 /5 Recent Reviews Call BookMore Details
Residence Inn by Marriott Paducah
+1-888-389-4121

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New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
3900 Coleman Crossing Circle, Paducah, KY 42001 +1-888-389-4121 ~34.97 miles east of Charleston
  • Midscale Suburban hotel
  • 74 suites in property
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From£68
Very good 4.0 /5 Reviews Call BookMore Details
Pear Tree Inn Paducah
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
5006 Hinkleville Rd., Paducah, KY 42001 +1-888-675-2083 ~35.47 miles east of Charleston
  • 2-star Suburban property
  • Free comp. breakfast
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From£42
Very good 4.0 /5 Reviews Call BookMore Details
Econo Lodge Dexter in Dexter
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
913 Outer Rd., Dexter, MO 63841 +1-800-716-8490 ~36.12 miles west of Charleston
  • Economical property
  • Check-in time: 11:00
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From£46
Average 3.0 /5 Reviews Call BookMore Details
Harrah's Metropolis Hotel & Casino - Metropolis
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
100 East Front St., Metropolis, IL 62960 +1-800-805-5223 ~36.52 miles east of Charleston
  • High end property
  • 7 floors in property
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From£122
Very good 4.0 /5 Reviews Call BookMore Details
Baymont by Wyndham Metropolis
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
203 East Front St., Metropolis, IL 62960 +1-888-965-1860 ~36.55 miles east of Charleston
  • Low Cost Riverfront hotel
  • Hotel has 2 floors
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From£34
Average 3.0 /5 Review Score Call BookMore Details
Sleep Inn & Mainstay Suites in Union City
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
1111 Blue Heron Lane, Union City, TN 38261 +1-888-788-5576 ~36.64 miles southeast of Charleston
  • Inexpensive Rural hotel
  • Check-in: 15:00
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From£46
Average 3.0 /5 Review Score Call BookMore Details
Travelodge by Wyndham Dexter in Dexter
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
1608 West Business U.s. 60, Dexter, MO 63841 +1-888-897-9207 ~36.87 miles west of Charleston
  • Midscale property
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From£51
Very good 4.0 /5 Read Reviews Call BookMore Details
 Econo Lodge Paducah West I-24 - Paducah
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
5120 Hinkleville Rd., Paducah, KY 42001 +1-888-311-4278 ~37.23 miles east of Charleston
  • 2-star Airport hotel
  • Hotel has 75 rooms
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From£46
Average 3.0 /5 Reviews Call BookMore Details
Drury Suites Paducah : 2930 James Sanders Blvd.
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
2930 James Sanders Blvd., Paducah, KY 42001 +1-888-469-4795 ~37.34 miles east of Charleston
  • Three Star Suburban property
  • Hotel has 120 suites
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From£76
Very good 4.0 /5 Review Score Call BookMore Details
Quality Suites Paducah I-24 in Paducah
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
2880 James Sanders Blvd., Paducah, KY 42001 Website +1-888-734-9421 ~37.41 miles east of Charleston
  • Low Cost Highway hotel
  • Gym is available on property
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From£46
Average 3.0 /5 Recent Reviews Call BookMore Details
Sleep Inn Union City
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
1111b Blue Heron Lane, Union City, TN 38261 +1-888-841-5292 ~37.44 miles southeast of Charleston
  • Cheap Rural property
  • 40 rooms in property
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From£59
Very good 4.0 /5 Recent Reviews Call BookMore Details
Comfort Inn & Suites near Six Flags - Lithia Springs
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
960 West Pointe Court, Lithia Springs, GA 30122 Website +1-888-455-5160 ~37.46 miles east of Charleston
  • 3-star Downtown property
  • 60 rooms in hotel
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From£53
Very good 4.0 /5 Reviews Call BookMore Details
Country Inn & Suites by Radisson, Paducah, KY
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
145 Mcbride Lane, Paducah, KY 42001 +1-888-965-8297 ~37.46 miles east of Charleston
  • 3-star Highway property
  • Gym is available on property
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From£37
Very good 4.0 /5 Recent Reviews Call BookMore Details
Baymont by Wyndham Paducah
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
5300 Old Cairo Rd., Paducah, KY 42001 +1-888-906-6358 ~37.50 miles east of Charleston
  • 3 star property
  • 74 sleeping rooms in hotel
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From£30
Poor 2.0 /5 Latest Reviews Call BookMore Details
Hotel 7 Inn in Paducah
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
5001 Hinkleville Rd., Paducah, KY 42001 +1-888-749-6785 ~37.51 miles east of Charleston
  • Low priced property
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From£46
Average 3.0 /5 Guest Reviews Call BookMore Details
Econo Lodge in Metropolis
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
1415 East 5th St., Metropolis, IL 62960 +1-888-878-9982 ~37.60 miles east of Charleston
  • Low priced property
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From£46
Terrible 1.0 /5 Latest Reviews Call BookMore Details

Next: See My Charleston Hotels with Pricing

Recent traveler reviews of Charleston, MO

Below are reviews of the city of Charleston, MO from an actual visitor's perspective.

"Easily Accessible"
Score 5.0 / 5

Easily accessible.

Mamon T., from 07-Dec-2023
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