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Charleston Missouri Hotels & Motels

Find the perfect hotel in Charleston using our hotel guide provided below. Find discounted hotel accommodations in or close to Charleston, MO for your upcoming individual or group travel. Discover the most popular Charleston, Missouri hotel and motel rooms. Browse the Charleston area hotels to find the perfect lodging! Please use the provided map of the Charleston hotels. Coordinating a group? Get Charleston Group Hotel Rates

Charleston Hotels & Accommodations

Super 8 by Wyndham Charleston/Sikeston East MO
+1-888-389-4121
310 South Story, Charleston, MO 63834
  • Low Cost Highway property
  • 60 sleeping rooms in hotel
From£31
Average 3.5 /5 Latest Reviews Call BookMore Details
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Quality Inn Charleston - Sikeston
+1-888-675-2083
102 Drake St., Charleston, MO 63834
  • Inexpensive Highway property
  • 9 suites in property
From£44
Average 3.0 /5 Hotel Reviews Call BookMore Details
Motel 6 Sikeston Mo - SIKESTON
+1-800-716-8490
110 South Interstate Dr., SIKESTON, MO 63801 ~11.02 miles west of Charleston
  • Two-star hotel
From£45
Average 3.0 /5 Guest Reviews Call BookMore Details
Best Western Plus Sikeston
+1-800-805-5223
120 South Interstate Dr., Sikeston, MO 63801 ~11.05 miles west of Charleston
  • 2-star Highway property
  • Hotel has 55 rooms
From£32
Very good 4.0 /5 Guest Reviews Call BookMore Details
Days Inn and Suites by Wyndham Sikeston : 220 South Interstate Dr.
+1-888-965-1860
220 South Interstate Dr., Sikeston, MO 63801 ~11.09 miles west of Charleston
  • Two star hotel
  • Fitness center on property
From£45
Average 3.0 /5 Review Score Call BookMore Details
Quality Inn Cairo I-57
+1-888-788-5576
13201 Kessler Rd., Cairo, IL 62914 ~11.20 miles northeast of Charleston
  • Affordable Highway hotel
  • Check-in: 3 pm
From£45
Poor 2.0 /5 Reviews Call BookMore Details
Super 8 by Wyndham Sikeston/Miner Area : 2609 East Malone
+1-888-897-9207
2609 East Malone, Sikeston, MO 63801 ~11.36 miles west of Charleston
  • Inexpensive Convention Center property
  • Check-in: 01:00
From£45
Average 3.0 /5 Reviews Call BookMore Details
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) : 100 Matthews Lane
+1-888-311-4278
100 Matthews Lane, Sikeston, MO 63801 ~11.37 miles west of Charleston
  • Midscale Highway property
  • Hotel has 40 rooms
From£60
Very good 4.0 /5 Recent Reviews Call BookMore Details
Comfort Inn in Sikeston
+1-888-469-4795
109 Matthews Lane, Sikeston, MO 63801 ~11.40 miles west of Charleston
  • Mid-scale Highway property
  • 64 sleeping rooms in hotel
From£64
Average 3.0 /5 Latest Reviews Call BookMore Details
Drury Inn & Suites Sikeston : 2608 East Malone Ave.
+1-888-734-9421
2608 East Malone Ave., Sikeston, MO 63801 ~11.45 miles west of Charleston
  • Midscale Highway hotel
  • 14 suites in hotel
From£78
Very good 4.5 /5 Read Reviews Call BookMore Details
Pear Tree Inn Sikeston
+1-888-841-5292
2602 East Malone, Sikeston, MO 63801 ~11.45 miles west of Charleston
  • Midscale Suburban hotel
  • 2 suites in hotel
From£60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Hampton Inn Sikeston - Sikeston
+1-888-455-5160
1240 Commerce Dr., Sikeston, MO 63801 ~14.31 miles west of Charleston
  • Midscale Rural hotel
  • 92 rooms in hotel
From£60
Average 3.0 /5 Reviews Call BookMore Details
Holiday Inn Express & Suites Sikeston An Ihg Hotel
+1-888-965-8297
115 Hospitality Dr., Sikeston, MO 63801 ~14.33 miles west of Charleston
  • Mid-scale Rural property
  • Gym is available on property
From£60
Average 3.0 /5 Read Reviews Call BookMore Details
Americas Best Value Inn Ullin Mounds : 128 Cheekwood Lane
+1-888-906-6358
128 Cheekwood Lane, Ullin, IL 62992 ~25.98 miles north of Charleston
  • 2-star hotel
  • Hotel has 40 rooms
From£45
Average 3.0 /5 Guest Reviews Call BookMore Details
Courtyard by Marriott Cape Girardeau Downtown
+1-888-749-6785
400 Broadway St., Cape Girardeau, MO 63701 ~28.56 miles north of Charleston
  • 3 star Downtown property
  • Check in: 3:00 pm
From£60
Very good 4.0 /5 Recent Reviews Call BookMore Details
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Candlewood Suites Cape Girardeau by IHG - Cape Girardeau
+1-888-878-9982
485 South Mount Auburn Rd., Cape Girardeau, MO 65703 ~28.61 miles northwest of Charleston
  • Low Cost Highway property
  • 4 floors in hotel
From£52
Very good 4.0 /5 Guest Reviews Call BookMore Details
Hampton Inn Cape Girardeau I 55 East - Cape Girardeau
+1-888-389-4485
207 South Mount Auburn Rd., Cape Girardeau, MO 63703 ~29.33 miles northwest of Charleston
  • 3-star Highway property
  • Hotel has 4 floors
From£60
Excellent 5.0 /5 Guest Reviews Call BookMore Details
Victorian Inn & Suites
+1-888-389-4121
3256 William St., Cape Girardeau, MO 63703 ~29.40 miles northwest of Charleston
  • Affordable Golf Course property
  • Hotel has 5 suites
From£59
Average 3.0 /5 Guest Reviews Call BookMore Details
Auburn Place Hotel & Suites
+1-888-675-2083
3265 Williams St., Cape Girardeau, MO 63702 ~29.41 miles northwest of Charleston
  • Mid-scale Highway hotel
  • Check-in time: 0300 pm
From£43
Very good 4.5 /5 Hotel Reviews Call BookMore Details
Holiday Inn Express & Suites Cape Girardeau I 55 in Cape Girardeau
+1-800-716-8490
3253 William St., Cape Girardeau, MO 63701 ~29.43 miles northwest of Charleston
  • 3 star hotel
  • Hotel has 102 rooms
From£60
Very good 4.5 /5 Guest Reviews Call BookMore Details
Fairfield Inn & Suites Cape Girardeau
+1-800-805-5223
433 Cape West Crossing, Cape Girardeay, MO 63703 ~29.46 miles northwest of Charleston
  • 3 star hotel
  • Check-in time: 3:00PM
From£60
Average 3.0 /5 Recent Reviews Call BookMore Details
Pear Tree Inn Cape Girardeau West in Cape Girardeau
+1-888-965-1860
103 Cape West Pkwy., Cape Girardeau, MO 63701 ~29.49 miles northwest of Charleston
  • Low Cost property
  • Fitness center on property
From£44
Average 3.0 /5 Reviews Call BookMore Details
Pear Tree Inn Cape Girardeau Medical Center : 3248 William St.
+1-888-788-5576
3248 William St., Cape Girardeau, MO 63701 ~29.50 miles northwest of Charleston
  • Two-star Highway property
  • Check in time: 3:00 pm
From£49
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Drury Suites Cape Girardeau
+1-888-897-9207
3303 Campster Dr., Cape Girardeau, MO 63701 ~29.60 miles northwest of Charleston
  • 3-star Highway hotel
  • Check-in: 3:00 PM
From£64
Very good 4.5 /5 Guest Reviews Call BookMore Details
Drury Plaza Hotel & Conference Center Cape Girardeau
+1-888-311-4278
3351 Percy Dr., Cape Girardeau, MO 63701 ~29.76 miles northwest of Charleston
  • 3 star property
  • 168 rooms in hotel
From£44
Average 3.0 /5 Guest Reviews Call BookMore Details
Drury Lodge : 104 South Vantage Dr.
+1-888-469-4795
104 South Vantage Dr., Cape Girardeau, MO 63701 ~29.77 miles northwest of Charleston
  • Affordable Highway property
  • Comp. Breakfast
From£60
Average 3.0 /5 Guest Reviews Call BookMore Details
Travel Inn - Marston
+1-888-734-9421
301 Route Ad, Marston, MO 63866 ~31.28 miles southwest of Charleston
  • Cheap Highway hotel
  • Free comp. breakfast
From£30
Poor 2.5 /5 Reviews Call BookMore Details
Travel Inn
+1-888-841-5292
301 State Highway Ad, Martson, MO 63866 ~31.46 miles southwest of Charleston
  • Cheap property
From£45
Poor 2.5 /5 Review Score Call BookMore Details
Red Roof Inn Marston - Marston
+1-888-455-5160
501 South Outer Rd., Marston, MO 63866 ~31.61 miles southwest of Charleston
  • Two-star hotel
  • Hotel has 2 floors
From£45
Average 3.0 /5 Read Reviews Call BookMore Details
Quality Inn in Cape Girardeau
+1-888-965-8297
2011 North Kingshighway St., Cape Girardeau, MO 63701 Website ~31.73 miles northwest of Charleston
  • 2 star hotel
  • Hotel has 49 rooms
From£45
Very good 4.0 /5 Hotel Reviews Call BookMore Details
TRU by Hilton Cape Girardeau : 2520 Veterans Memorial Dr.
+1-888-906-6358
2520 Veterans Memorial Dr., Cape Girardeau, MO 63701 ~32.92 miles northwest of Charleston
  • Midscale Highway hotel
  • Fitness center on property
From£60
Average 3.0 /5 Latest Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Jackson / Cape Girardeau
+1-888-749-6785
3003 South Old Orchard Rd., Jackson, MO 63755 ~33.46 miles northwest of Charleston
  • Mid-scale Highway hotel
  • 9 suites in hotel
From£64
Very good 4.0 /5 Review Score Call BookMore Details
Comfort Suites Jackson-Cape Girardeau in Jackson
+1-888-878-9982
2904 Old Orchard Rd., Jackson, MO 63755 Website ~33.57 miles northwest of Charleston
  • Three Star Highway hotel
  • 3 floors in hotel
From£49
Average 3.0 /5 Reviews Call BookMore Details
Comfort Suites in Jackson
+1-888-389-4485
2904 Old Orchard Rd., Jackson, 63755 United States ~33.57 miles northwest of Charleston
  • Expensive Highway property
  • 64 rooms in property
From£94
Average 3.0 /5 Reviews Call BookMore Details
Residence Inn by Marriott Paducah - Paducah
+1-888-389-4121
3900 Coleman Crossing Circle, Paducah, KY 42001 ~34.97 miles east of Charleston
  • Mid-scale Suburban property
  • 74 sleeping rooms in hotel
From£67
Very good 4.0 /5 Guest Reviews Call BookMore Details
Pear Tree Inn Paducah in Paducah
+1-888-675-2083
5006 Hinkleville Rd., Paducah, KY 42001 ~35.47 miles east of Charleston
  • 2-star Suburban hotel
  • Check in: 3:00 PM
From£41
Very good 4.0 /5 Read Reviews Call BookMore Details
Econo Lodge Dexter
+1-800-716-8490
913 Outer Rd., Dexter, MO 63841 ~36.12 miles west of Charleston
  • 2 star property
  • Comp. Breakfast
From£45
Average 3.0 /5 Read Reviews Call BookMore Details
Harrah's Metropolis Hotel & Casino - Metropolis
+1-800-805-5223
100 East Front St., Metropolis, IL 62960 ~36.52 miles east of Charleston
  • 4 star property
  • Hotel has 7 floors
From£120
Very good 4.0 /5 Guest Reviews Call BookMore Details
Baymont by Wyndham Metropolis
+1-888-965-1860
203 East Front St., Metropolis, IL 62960 ~36.55 miles east of Charleston
  • Two-star Riverfront hotel
  • Access to gym on-site
From£33
Average 3.0 /5 Latest Reviews Call BookMore Details
Sleep Inn & Mainstay Suites : 1111 Blue Heron Lane
+1-888-788-5576
1111 Blue Heron Lane, Union City, TN 38261 ~36.64 miles southeast of Charleston
  • Low-priced Rural hotel
  • 40 rooms in hotel
From£45
Average 3.0 /5 Guest Reviews Call BookMore Details
Travelodge by Wyndham Dexter : 1608 West Business U.s. 60
+1-888-897-9207
1608 West Business U.s. 60, Dexter, MO 63841 ~36.87 miles west of Charleston
  • Midscale hotel
From£50
Very good 4.0 /5 Read Reviews Call BookMore Details
 Econo Lodge Paducah West I-24
+1-888-311-4278
5120 Hinkleville Rd., Paducah, KY 42001 ~37.23 miles east of Charleston
  • Low priced Airport hotel
  • Hotel has 75 rooms
From£45
Average 3.0 /5 Reviews Call BookMore Details
Drury Suites Paducah : 2930 James Sanders Blvd.
+1-888-469-4795
2930 James Sanders Blvd., Paducah, KY 42001 ~37.34 miles east of Charleston
  • Three Star Suburban property
  • 2 conference rooms in property
From£74
Very good 4.0 /5 Guest Reviews Call BookMore Details
Quality Suites Paducah I-24
+1-888-734-9421
2880 James Sanders Blvd., Paducah, KY 42001 Website ~37.41 miles east of Charleston
  • 2 star Highway hotel
  • Access to gym on-site
From£45
Average 3.0 /5 Hotel Reviews Call BookMore Details
Sleep Inn Union City
+1-888-841-5292
1111b Blue Heron Lane, Union City, TN 38261 ~37.44 miles southeast of Charleston
  • Cheap Rural property
  • 40 rooms in hotel
From£58
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Comfort Inn & Suites near Six Flags in Lithia Springs
+1-888-455-5160
960 West Pointe Court, Lithia Springs, GA 30122 Website ~37.46 miles east of Charleston
  • Three Star Downtown property
  • Check-in time: 3:00pm
From£52
Very good 4.0 /5 Review Score Call BookMore Details
Country Inn & Suites by Radisson, Paducah, KY in Paducah
+1-888-965-8297
145 Mcbride Lane, Paducah, KY 42001 ~37.46 miles east of Charleston
  • 3-star Highway hotel
  • Comp. Breakfast
From£36
Very good 4.0 /5 Recent Reviews Call BookMore Details
Baymont by Wyndham Paducah - Paducah
+1-888-906-6358
5300 Old Cairo Rd., Paducah, KY 42001 ~37.50 miles east of Charleston
  • Mid-scale property
  • 4 suites in hotel
Hotel 7 Inn in Paducah
+1-888-749-6785
5001 Hinkleville Rd., Paducah, KY 42001 ~37.51 miles east of Charleston
  • Economical hotel
From£45
Average 3.0 /5 Review Score Call BookMore Details
Econo Lodge
+1-888-878-9982
1415 East 5th St., Metropolis, IL 62960 ~37.60 miles east of Charleston
  • Cheap property
  • 45 sleeping rooms in hotel
From£45
Terrible 1.0 /5 Hotel Reviews Call BookMore Details

Next: See My Charleston Hotels with Pricing

Graph of Charleston, MO Hotel Prices for Next 20 Days

Rates shown are nightly rates before taxes and do not necessarily reflect all Charleston, MO discounts available. The chart reflects the cheapest Charleston hotel for each day and each star rating category.

FAQs about hotels in Charleston

What are the most favored hotels in Charleston?

Hampton Inn Cape Girardeau I 55 East, Drury Inn & Suites Sikeston and Auburn Place Hotel & Suites are the best rated hotels based on customer reviews in the last 365 days.

What are the most luxurious hotels in Charleston?

Comfort Suites, Harrah's Metropolis Hotel & Casino and Quality Inn Cairo I-57 are the top 3 luxury hotels near Charleston city center.

What hotels are closest to the city center of Charleston?

Super 8 by Wyndham Charleston, Quality Inn Charleston - Sikeston, and Motel 6 Sikeston Mo are the properties closest to Charleston city center.

What are the best independent hotels in Charleston?

Auburn Place Hotel & Suites, Drury Suites Cape Girardeau and Travel Inn & Suites - Sikeston are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels in Charleston?

Courtyard by Marriott Cape Girardeau Downtown, Residence Inn by Marriott Paducah and Fairfield Inn & Suites Cape Girardeau are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best Choice Hotels branded hotels in Charleston?

Quality Inn, Sleep Inn Union City and Comfort Inn & Suites near Six Flags are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the best IHG hotels in Charleston?

Holiday Inn Express & Suites Cape Girardeau I 55, Candlewood Suites Cape Girardeau by IHG and Holiday Inn Express & Suites Sikeston An Ihg Hotel are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

Recent traveler reviews of Charleston, MO

Below are reviews of the city of Charleston, MO from an actual visitor's perspective.

"Easily Accessible"
Score 5.0 / 5

Easily accessible.

Mamon T., from 07-Dec-2023
The average traveler rating of the city of Charleston, MO shown above is 5.0 out of 5 based on 1 reviews
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