Cairo Illinois Accommodations

Find hotels & motels in Cairo using the list below. Search for cheap and discounted hotel and motel rates in or close to Cairo, IL for your upcoming individual or group travel. Discover the best Cairo Illinois hotel/motel rooms. Review the Cairo hotel list below to find the perfect lodging. We also have a map of the Cairo hotels.

Cairo Hotels/Accommodations

Quality Inn Cairo I-57 in Cairo
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
13201 Kessler Rd., Cairo, IL 62914 +1-888-389-4121
  • Three Star Highway property
  • Hotel has 38 rooms
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From£45
Poor 2.0 /5 Recent Reviews Call BookMore Details
Super 8 by Wyndham Charleston/Sikeston East MO : 310 South Story
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
310 South Story, Charleston, MO 63834 +1-888-675-2083 ~10.14 miles southwest of Cairo
  • Two-star Highway property
  • Check-in time: 3:00pm
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From£31
Average 3.5 /5 Hotel Reviews Call BookMore Details
Quality Inn Charleston - Sikeston
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
102 Drake St., Charleston, MO 63834 +1-800-716-8490 ~11.90 miles southwest of Cairo
  • Low priced Highway hotel
  • Complimentary breakfast is offered
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From£44
Average 3.0 /5 Latest Reviews Call BookMore Details
Americas Best Value Inn Ullin Mounds : 128 Cheekwood Lane
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
128 Cheekwood Lane, Ullin, IL 62992 +1-800-805-5223 ~17.90 miles north of Cairo
  • 2 star hotel
  • 40 rooms in property
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From£45
Average 3.0 /5 Read Reviews Call BookMore Details
Motel 6 Sikeston Mo
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
110 South Interstate Dr., SIKESTON, MO 63801 +1-888-965-1860 ~21.01 miles west of Cairo
  • Two-star hotel
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From£45
Average 3.0 /5 Guest Reviews Call BookMore Details
Best Western Plus Sikeston
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
120 South Interstate Dr., Sikeston, MO 63801 +1-888-788-5576 ~21.04 miles west of Cairo
  • Two-star Highway property
  • Hotel has a green policy See policy
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From£32
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Days Inn and Suites by Wyndham Sikeston in Sikeston
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
220 South Interstate Dr., Sikeston, MO 63801 +1-888-897-9207 ~21.11 miles west of Cairo
  • Economy hotel
  • Check-in time: 03:00 PM
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From£45
Average 3.0 /5 Recent Reviews Call BookMore Details
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) in Sikeston
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
100 Matthews Lane, Sikeston, MO 63801 +1-888-311-4278 ~21.35 miles west of Cairo
  • Mid-scale Highway property
  • Free comp. breakfast
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From£60
Very good 4.0 /5 Reviews Call BookMore Details
Super 8 by Wyndham Sikeston/Miner Area
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
2609 East Malone, Sikeston, MO 63801 +1-888-469-4795 ~21.37 miles west of Cairo
  • 2-star Convention Center property
  • Check in: 01:00
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From£45
Average 3.0 /5 Latest Reviews Call BookMore Details
Comfort Inn in Sikeston
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
109 Matthews Lane, Sikeston, MO 63801 +1-888-734-9421 ~21.39 miles west of Cairo
  • Affordable Highway hotel
  • Check in time: 11:00
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From£64
Average 3.0 /5 Read Reviews Call BookMore Details
Drury Inn & Suites Sikeston in Sikeston
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
2608 East Malone Ave., Sikeston, MO 63801 +1-888-841-5292 ~21.42 miles west of Cairo
  • Mid-scale Highway hotel
  • Hotel has 5 floors
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From£79
Very good 4.5 /5 Latest Reviews Call BookMore Details
Pear Tree Inn Sikeston
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
2602 East Malone, Sikeston, MO 63801 +1-888-455-5160 ~21.42 miles west of Cairo
  • Three Star Suburban hotel
  • 4 floors in hotel
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From£60
Average 3.0 /5 Review Score Call BookMore Details
Hampton Inn Sikeston - Sikeston
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
1240 Commerce Dr., Sikeston, MO 63801 +1-888-965-8297 ~24.53 miles west of Cairo
  • Midscale Rural hotel
  • 92 sleeping rooms in hotel
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From£60
Average 3.0 /5 Recent Reviews Call BookMore Details
Holiday Inn Express & Suites Sikeston An Ihg Hotel
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
115 Hospitality Dr., Sikeston, MO 63801 +1-888-906-6358 ~24.55 miles west of Cairo
  • Mid-scale Rural hotel
  • 73 sleeping rooms in hotel
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From£60
Average 3.0 /5 Review Score Call BookMore Details
Residence Inn by Marriott Paducah : 3900 Coleman Crossing Circle
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
3900 Coleman Crossing Circle, Paducah, KY 42001 +1-888-749-6785 ~25.70 miles east of Cairo
  • 3-star Suburban property
  • Hotel has 74 suites
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From£67
Very good 4.0 /5 Review Score Call BookMore Details
Pear Tree Inn Paducah - Paducah
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
5006 Hinkleville Rd., Paducah, KY 42001 +1-888-878-9982 ~25.80 miles east of Cairo
  • Inexpensive Suburban property
  • Check-in time: 3:00 PM
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From£41
Very good 4.0 /5 Reviews Call BookMore Details
Harrah's Metropolis Hotel & Casino - Metropolis
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
100 East Front St., Metropolis, IL 62960 +1-888-389-4485 ~26.30 miles east of Cairo
  • High end hotel
  • Hotel has 7 floors
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From£121
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Baymont by Wyndham Metropolis
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
203 East Front St., Metropolis, IL 62960 +1-888-389-4121 ~26.33 miles east of Cairo
  • 2 star Riverfront hotel
  • Fitness / Gym is on-site
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From£34
Average 3.0 /5 Reviews Call BookMore Details
Econo Lodge - Metropolis
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
1415 East 5th St., Metropolis, IL 62960 +1-888-675-2083 ~27.39 miles east of Cairo
  • Inexpensive property
  • 45 sleeping rooms in hotel
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From£45
Terrible 1.0 /5 Hotel Reviews Call BookMore Details
 Econo Lodge Paducah West I-24
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
5120 Hinkleville Rd., Paducah, KY 42001 +1-800-716-8490 ~27.58 miles east of Cairo
  • Cheap Airport property
  • Check-in time: 15:00pm
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From£45
Average 3.0 /5 Guest Reviews Call BookMore Details
Courtyard by Marriott Cape Girardeau Downtown
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
400 Broadway St., Cape Girardeau, MO 63701 +1-800-805-5223 ~27.66 miles northwest of Cairo
  • Mid-scale Downtown hotel
  • Hotel has 5 floors
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From£60
Very good 4.0 /5 Review Score Call BookMore Details
Baymont by Wyndham Paducah in Paducah
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
5300 Old Cairo Rd., Paducah, KY 42001 +1-888-965-1860 ~27.67 miles east of Cairo
  • Affordable property
  • Hotel has 4 suites
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From£30
Poor 2.0 /5 Latest Reviews Call BookMore Details
Drury Suites Paducah
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
2930 James Sanders Blvd., Paducah, KY 42001 +1-888-788-5576 ~27.73 miles east of Cairo
  • 3-star Suburban hotel
  • Check in: 3:00 PM
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From£75
Very good 4.0 /5 Read Reviews Call BookMore Details
Quality Suites Paducah I-24 - Paducah
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
2880 James Sanders Blvd., Paducah, KY 42001 Website +1-888-897-9207 ~27.76 miles east of Cairo
  • Low priced Highway hotel
  • Hotel has an eco-friendly policy Read more
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From£45
Average 3.0 /5 Reviews Call BookMore Details
Country Inn & Suites by Radisson, Paducah, KY in Paducah
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
145 Mcbride Lane, Paducah, KY 42001 +1-888-311-4278 ~27.83 miles east of Cairo
  • Midscale Highway property
  • Gym / Fitness Center Available
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From£37
Very good 4.0 /5 Recent Reviews Call BookMore Details
Comfort Inn & Suites near Six Flags : 960 West Pointe Court
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
960 West Pointe Court, Lithia Springs, GA 30122 Website +1-888-469-4795 ~27.83 miles east of Cairo
  • Mid-scale Downtown hotel
  • Check-in: 3:00pm
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From£53
Very good 4.0 /5 Review Score Call BookMore Details
Hotel 7 Inn - Paducah
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
5001 Hinkleville Rd., Paducah, KY 42001 +1-888-734-9421 ~27.84 miles east of Cairo
  • Two star hotel
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From£45
Average 3.0 /5 Recent Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Paducah
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
3960 Coleman Crossing Cir, Paducah, KY 42001 +1-888-841-5292 ~27.93 miles east of Cairo
  • Mid-scale Highway hotel
  • 77 rooms in hotel
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From£60
Average 3.0 /5 Review Score Call BookMore Details
Candlewood Suites Paducah, an IHG Hotel - Paducah
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
3940 Coleman Crossing Circle, Paducah, KY 42001 +1-888-455-5160 ~27.94 miles east of Cairo
  • Mid-scale Rural hotel
  • 4 floors in property
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From£45
Very good 4.0 /5 Reviews Call BookMore Details
Homewood Suites by Hilton Paducah in Paducah
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
3925 Coleman Crossing Cir, Paducah, KY 42001 +1-888-965-8297 ~27.97 miles east of Cairo
  • Three Star Highway hotel
  • Gym is available on property
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From£82
Very good 4.0 /5 Reviews Call BookMore Details
Comfort Suites : 3918 Coleman Crossing Cir Paducah Ky 42001
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
3918 Coleman Crossing Cir Paducah Ky 42001, Paducah, KY 42001 +1-888-906-6358 ~27.99 miles east of Cairo
  • Inexpensive Rural property
  • Free comp. breakfast
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From£45
Average 3.0 /5 Latest Reviews Call BookMore Details
Comfort Inn Paducah - Paducah
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
5135 Cairo Rd., Paducah, KY 42001 +1-888-749-6785 ~28.01 miles east of Cairo
  • Mid-scale hotel
  • Fitness + Health Center
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From£44
Very good 4.0 /5 Review Score Call BookMore Details
Fairfield Inn & Suites by Marriott Paducah - Paducah
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
3950 Coleman Crossing Circle, Paducah, KY 42001 +1-888-878-9982 ~28.03 miles east of Cairo
  • Affordable Rural hotel
  • Check-in time: 3:00 pm
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From£56
Very good 4.0 /5 Guest Reviews Call BookMore Details
Red Roof Inn Paducah : 5106 Old Cairo Rd.
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
5106 Old Cairo Rd., Paducah, KY 42001 +1-888-389-4485 ~28.04 miles east of Cairo
  • 2 star property
  • Hotel has 8 suites
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From£34
Average 3.5 /5 Hotel Reviews Call BookMore Details
American Inn in Paducah
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
5125 Cairo Rd., Paducah, KY 42001 +1-888-389-4121 ~28.05 miles east of Cairo
  • Low Cost hotel
  • Free comp. breakfast
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From£28
Very good 4.0 /5 Guest Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites Paducah West by IHG
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
3996 Hinkleville Rd., Paducah, KY 42001 +1-888-675-2083 ~28.07 miles east of Cairo
  • Midscale Highway hotel
  • Check-in: 3:00 PM
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From£60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Auburn Place Hotel & Suites - Paducah : 3994 Hinkleville Rd.
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
3994 Hinkleville Rd., Paducah, KY 42001 +1-800-716-8490 ~28.08 miles east of Cairo
  • 3-star Airport property
  • 76 suites in property
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From£60
Very good 4.0 /5 Read Reviews Call BookMore Details
Courtyard by Marriott Paducah in Paducah
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
3835 Technology Dr., Paducah, KY 42001 +1-800-805-5223 ~28.32 miles east of Cairo
  • Midscale Suburban property
  • Check-in: 3:00 pm
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From£67
Very good 4.0 /5 Recent Reviews Call BookMore Details
Drury Inn Paducah
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
3975 Hinkleville Rd., Paducah, KY 42001 +1-888-965-1860 ~28.73 miles east of Cairo
  • Mid-scale Suburban property
  • Complimentary breakfast is offered
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From£60
Very good 4.5 /5 Read Reviews Call BookMore Details
Candlewood Suites Cape Girardeau by IHG in Cape Girardeau
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
485 South Mount Auburn Rd., Cape Girardeau, MO 65703 +1-888-788-5576 ~28.78 miles northwest of Cairo
  • 2 star Highway property
  • Hotel has an eco-friendly policy See policy
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From£52
Very good 4.0 /5 Reviews Call BookMore Details
Days Inn by Wyndham Paducah in Paducah
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
3901 Hinkleville Rd., Paducah, KY 42001 +1-888-897-9207 ~28.78 miles east of Cairo
  • Two star Highway property
  • Hotel has 122 rooms
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From£37
Average 3.0 /5 Read Reviews Call BookMore Details
Quality Inn & Suites Metropolis I-24
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
2118 East 5th St., Metropolis, IL 62960 +1-888-311-4278 ~28.90 miles east of Cairo
  • Midscale property
  • 52 rooms in property
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From£60
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Super 8 by Wyndham Metropolis - Metropolis
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
2055 East 5th St., Metropolis, IL 62960 +1-888-469-4795 ~28.91 miles east of Cairo
  • 2-star Highway hotel
  • Check in time: 02:00PM
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From£45
Average 3.0 /5 Read Reviews Call BookMore Details
Travelers Inn and Suites in Paducah
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
2550 Lone Oak Rd., Paducah, KY 42003 +1-888-734-9421 ~28.91 miles east of Cairo
  • Low-priced hotel
  • 30 suites in hotel
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From£28
Very good 4.0 /5 Review Score Call BookMore Details
Motel 6 Metropolis Il
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
2119 East 5th St., Metropolis, IL 62960 +1-888-841-5292 ~29.06 miles east of Cairo
  • Two-star property
  • Check-in time: 11:00 AM
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From£45
Average 3.0 /5 Latest Reviews Call BookMore Details
Holiday Inn Express Metropolis by IHG
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
2179 East 5th St., Metropolis, IL 62960 +1-888-455-5160 ~29.12 miles east of Cairo
  • Three Star Rural property
  • 3 floors in hotel
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From£49
Very good 4.0 /5 Guest Reviews Call BookMore Details
Hampton Inn Cape Girardeau I 55 East in Cape Girardeau
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
207 South Mount Auburn Rd., Cape Girardeau, MO 63703 +1-888-965-8297 ~29.42 miles northwest of Cairo
  • Midscale Highway property
  • 4 floors in property
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From£60
Excellent 5.0 /5 Hotel Reviews Call BookMore Details
Victorian Inn & Suites
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
3256 William St., Cape Girardeau, MO 63703 +1-888-906-6358 ~29.43 miles northwest of Cairo
  • Midscale Golf Course property
  • 2 floors in hotel
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From£60
Average 3.0 /5 Review Score Call BookMore Details
Auburn Place Hotel & Suites - Cape Girardeau
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
3265 Williams St., Cape Girardeau, MO 63702 +1-888-749-6785 ~29.44 miles northwest of Cairo
  • 3-star Highway hotel
  • Hotel has 5 suites
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From£44
Very good 4.5 /5 Guest Reviews Call BookMore Details
Holiday Inn Express & Suites Cape Girardeau I 55 in Cape Girardeau
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
3253 William St., Cape Girardeau, MO 63701 +1-888-878-9982 ~29.51 miles northwest of Cairo
  • Three Star property
  • Gym / Fitness Center Available
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From£60
Very good 4.5 /5 Guest Reviews Call BookMore Details

Next: See My Cairo Hotels with Pricing

Verified reviews of the city: Cairo, IL

Below are reviews of the city of Cairo, IL from an actual visitor's perspective.

""
Score 5.0 / 5

Family

Beverly T., from 10-Mar-2025
""
Score 4.0 / 5

Family

Beverly T., from 10-Mar-2025
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