Cairo Illinois Accommodations

Find hotels & motels in Cairo using the list below. Search for cheap and discounted hotel and motel rates in or close to Cairo, IL for your upcoming individual or group travel. Discover the best Cairo Illinois hotel/motel rooms. Review the Cairo hotel list below to find the perfect lodging. We also have a map of the Cairo hotels.

Cairo Hotels/Accommodations

Quality Inn Cairo I-57 : 13201 Kessler Rd.

+1-888-389-4121

13201 Kessler Rd., Cairo, IL 62914

Mid-scale Highway hotel
2 floors in hotel

Photo of Quality Inn Cairo I-57

From$60

Poor 2.0 /5 Hotel Reviews Call BookMore Details

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Super 8 by Wyndham Charleston/Sikeston East MO

+1-888-675-2083

310 South Story, Charleston, MO 63834 ~10.14 miles southwest of Cairo

2-star Highway property
60 rooms in hotel

Photo of Super 8 by Wyndham Charleston/Sikeston East MO

From$42

Average 3.5 /5 Guest Reviews Call BookMore Details

Quality Inn Charleston - Sikeston - Charleston

+1-800-716-8490

102 Drake St., Charleston, MO 63834 ~11.90 miles southwest of Cairo

Cheap Highway property
Check in: 3:00PM

Image of Quality Inn Charleston - Sikeston

From$59

Average 3.0 /5 Review Score Call BookMore Details

Americas Best Value Inn Ullin Mounds - Ullin

+1-800-805-5223

128 Cheekwood Lane, Ullin, IL 62992 ~17.90 miles north of Cairo

2 star hotel
40 rooms in hotel

Image of Americas Best Value Inn Ullin Mounds

From$60

Average 3.0 /5 Recent Reviews Call BookMore Details

Motel 6 Sikeston Mo in SIKESTON

+1-888-965-1860

110 South Interstate Dr., SIKESTON, MO 63801 ~21.01 miles west of Cairo

Inexpensive property

Photo of Motel 6 Sikeston Mo

From$60

Average 3.0 /5 Hotel Reviews Call BookMore Details

Best Western Plus Sikeston - Sikeston

+1-888-788-5576

120 South Interstate Dr., Sikeston, MO 63801 ~21.04 miles west of Cairo

Cheap Highway property
Hotel has an eco-friendly policy See more

Photo of Best Western Plus Sikeston

From$43

Very Good 4.0 /5 Read Reviews Call BookMore Details

Days Inn and Suites by Wyndham Sikeston

+1-888-897-9207

220 South Interstate Dr., Sikeston, MO 63801 ~21.11 miles west of Cairo

2-star hotel
Fitness / Gym is on-site

Exterior of Days Inn and Suites by Wyndham Sikeston

From$60

Average 3.0 /5 Review Score Call BookMore Details

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

+1-888-311-4278

100 Matthews Lane, Sikeston, MO 63801 ~21.35 miles west of Cairo

Midscale Highway hotel
Free breakfast

Exterior of Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

From$80

Very Good 4.0 /5 Review Score Call BookMore Details

Super 8 by Wyndham Sikeston/Miner Area : 2609 East Malone

+1-888-469-4795

2609 East Malone, Sikeston, MO 63801 ~21.37 miles west of Cairo

Cheap Convention Center hotel
Check in time: 01:00

Photo of Super 8 by Wyndham Sikeston/Miner Area

From$60

Average 3.0 /5 Read Reviews Call BookMore Details

Comfort Inn : 109 Matthews Lane

+1-888-734-9421

109 Matthews Lane, Sikeston, MO 63801 ~21.39 miles west of Cairo

Three Star Highway hotel
Hotel has 64 rooms

Exterior of Comfort Inn

From$85

Average 3.0 /5 Guest Reviews Call BookMore Details

Drury Inn & Suites Sikeston - Sikeston

+1-888-841-5292

2608 East Malone Ave., Sikeston, MO 63801 ~21.42 miles west of Cairo

3-star Highway property
Comp. Breakfast

Photo of Drury Inn & Suites Sikeston

From$104

Very Good 4.5 /5 Latest Reviews Call BookMore Details

Pear Tree Inn Sikeston - Sikeston

+1-888-455-5160

2602 East Malone, Sikeston, MO 63801 ~21.42 miles west of Cairo

3 star Suburban hotel
Check-in: 3:00 PM

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From$80

Average 3.0 /5 Guest Reviews Call BookMore Details

Hampton Inn Sikeston

+1-888-965-8297

1240 Commerce Dr., Sikeston, MO 63801 ~24.53 miles west of Cairo

3-star Rural property
Check in time: 3:00 PM

Photo of Hampton Inn Sikeston

From$80

Average 3.0 /5 Guest Reviews Call BookMore Details

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Holiday Inn Express & Suites Sikeston An Ihg Hotel

+1-888-906-6358

115 Hospitality Dr., Sikeston, MO 63801 ~24.55 miles west of Cairo

Three Star Rural property
3 floors in hotel

Exterior of Holiday Inn Express & Suites Sikeston An Ihg Hotel

From$80

Average 3.0 /5 Hotel Reviews Call BookMore Details

Residence Inn by Marriott Paducah : 3900 Coleman Crossing Circle

+1-888-749-6785

3900 Coleman Crossing Circle, Paducah, KY 42001 ~25.70 miles east of Cairo

3-star Suburban hotel
Fitness / Gym is on-site

Image of Residence Inn by Marriott Paducah

From$89

Very Good 4.0 /5 Recent Reviews Call BookMore Details

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Pear Tree Inn Paducah

+1-888-878-9982

5006 Hinkleville Rd., Paducah, KY 42001 ~25.80 miles east of Cairo

Two star Suburban property
Fitness / Gym is on-site

Image of Pear Tree Inn Paducah

From$55

Very Good 4.0 /5 Guest Reviews Call BookMore Details

Harrah's Metropolis Hotel & Casino - Metropolis

+1-888-389-4485

100 East Front St., Metropolis, IL 62960 ~26.30 miles east of Cairo

4-star property
252 rooms in property

Image of Harrah's Metropolis Hotel & Casino

From$160

Very Good 4.0 /5 Hotel Reviews Call BookMore Details

Baymont by Wyndham Metropolis in Metropolis

+1-888-389-4121

203 East Front St., Metropolis, IL 62960 ~26.33 miles east of Cairo

Two star Riverfront property
117 rooms in hotel

Exterior of Baymont by Wyndham Metropolis

From$45

Average 3.0 /5 Hotel Reviews Call BookMore Details

Econo Lodge in Metropolis

+1-888-675-2083

1415 East 5th St., Metropolis, IL 62960 ~27.39 miles east of Cairo

Economy hotel
45 sleeping rooms in hotel

Exterior of Econo Lodge

From$60

Not Good 1.0 /5 Read Reviews Call BookMore Details

Econo Lodge Paducah West I-24

+1-800-716-8490

5120 Hinkleville Rd., Paducah, KY 42001 ~27.58 miles east of Cairo

Low Cost Airport property
Has environment-friendly policy Read more

Photo of Econo Lodge Paducah West I-24

From$60

Average 3.0 /5 Recent Reviews Call BookMore Details

Courtyard by Marriott Cape Girardeau Downtown : 400 Broadway St.

+1-800-805-5223

400 Broadway St., Cape Girardeau, MO 63701 ~27.66 miles northwest of Cairo

Mid-scale Downtown property
Hotel has 78 rooms

Exterior of Courtyard by Marriott Cape Girardeau Downtown

From$80

Very Good 4.0 /5 Hotel Reviews Call BookMore Details

Baymont by Wyndham Paducah

+1-888-965-1860

5300 Old Cairo Rd., Paducah, KY 42001 ~27.67 miles east of Cairo

3 star property
3 floors in property

Photo of Baymont by Wyndham Paducah

From$40

Poor 2.0 /5 Read Reviews Call BookMore Details

Drury Suites Paducah

+1-888-788-5576

2930 James Sanders Blvd., Paducah, KY 42001 ~27.73 miles east of Cairo

Midscale Suburban hotel
Hotel has an eco-friendly policy Read more

Exterior of Drury Suites Paducah

From$99

Very Good 4.0 /5 Hotel Reviews Call BookMore Details

Quality Suites Paducah I-24 in Paducah

+1-888-897-9207

2880 James Sanders Blvd., Paducah, KY 42001 Website ~27.76 miles east of Cairo

Cheap Highway property
Hotel has an eco-friendly policy See more

Photo of Quality Suites Paducah I-24

From$60

Average 3.0 /5 Review Score Call BookMore Details

Country Inn & Suites by Radisson, Paducah, KY - Paducah

+1-888-311-4278

145 Mcbride Lane, Paducah, KY 42001 ~27.83 miles east of Cairo

Midscale Highway hotel
60 rooms in property

Photo of Country Inn & Suites by Radisson, Paducah, KY

From$49

Very Good 4.0 /5 Read Reviews Call BookMore Details

Comfort Inn & Suites near Six Flags

+1-888-469-4795

960 West Pointe Court, Lithia Springs, GA 30122 Website ~27.83 miles east of Cairo

3-star Downtown hotel
5 suites in property

Photo of Comfort Inn & Suites near Six Flags

From$70

Very Good 4.0 /5 Latest Reviews Call BookMore Details

Hotel 7 Inn

+1-888-734-9421

5001 Hinkleville Rd., Paducah, KY 42001 ~27.84 miles east of Cairo

Low priced property

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From$60

Average 3.0 /5 Hotel Reviews Call BookMore Details

La Quinta Inn & Suites by Wyndham Paducah

+1-888-841-5292

3960 Coleman Crossing Cir, Paducah, KY 42001 ~27.93 miles east of Cairo

3 star Highway property
Hotel has an eco-friendly policy Learn more

Exterior of La Quinta Inn & Suites by Wyndham Paducah

From$80

Average 3.0 /5 Review Score Call BookMore Details

Candlewood Suites Paducah, an IHG Hotel

+1-888-455-5160

3940 Coleman Crossing Circle, Paducah, KY 42001 ~27.94 miles east of Cairo

Affordable Rural property
Check-in: 3:00pm

Photo of Candlewood Suites Paducah, an IHG Hotel

From$60

Very Good 4.0 /5 Latest Reviews Call BookMore Details

Homewood Suites by Hilton Paducah in Paducah

+1-888-965-8297

3925 Coleman Crossing Cir, Paducah, KY 42001 ~27.97 miles east of Cairo

Three Star Highway property
97 rooms in property

Photo of Homewood Suites by Hilton Paducah

From$109

Very Good 4.0 /5 Recent Reviews Call BookMore Details

Comfort Suites - Paducah

+1-888-906-6358

3918 Coleman Crossing Cir Paducah Ky 42001, Paducah, KY 42001 ~27.99 miles east of Cairo

Two-star Rural property
72 rooms in hotel

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From$60

Average 3.0 /5 Review Score Call BookMore Details

Comfort Inn Paducah

+1-888-749-6785

5135 Cairo Rd., Paducah, KY 42001 ~28.01 miles east of Cairo

Midscale hotel
64 suites in hotel

Exterior of Comfort Inn Paducah

From$59

Very Good 4.0 /5 Guest Reviews Call BookMore Details

Fairfield Inn & Suites by Marriott Paducah - Paducah

+1-888-878-9982

3950 Coleman Crossing Circle, Paducah, KY 42001 ~28.03 miles east of Cairo

3 star Rural hotel
Comp. Breakfast

Photo of Fairfield Inn & Suites by Marriott Paducah

From$75

Very Good 4.0 /5 Reviews Call BookMore Details

Red Roof Inn Paducah : 5106 Old Cairo Rd.

+1-888-389-4485

5106 Old Cairo Rd., Paducah, KY 42001 ~28.04 miles east of Cairo

Two-star hotel
3 floors in hotel

Photo of Red Roof Inn Paducah

From$45

Average 3.5 /5 Guest Reviews Call BookMore Details

American Inn in Paducah

+1-888-389-4121

5125 Cairo Rd., Paducah, KY 42001 ~28.05 miles east of Cairo

Economy hotel
Free breakfast

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From$37

Very Good 4.0 /5 Read Reviews Call BookMore Details

Holiday Inn Express Hotel & Suites Paducah West, an IHG Hotel : 3996 Hinkleville Rd.

+1-888-675-2083

3996 Hinkleville Rd., Paducah, KY 42001 ~28.07 miles east of Cairo

Three Star Highway hotel
3 floors in property

Image of Holiday Inn Express Hotel & Suites Paducah West, an IHG Hotel

From$80

Average 3.0 /5 Latest Reviews Call BookMore Details

Auburn Place Hotel & Suites - Paducah in Paducah

+1-800-716-8490

3994 Hinkleville Rd., Paducah, KY 42001 ~28.08 miles east of Cairo

Mid-scale Airport property
Free comp. breakfast

Exterior of Auburn Place Hotel & Suites - Paducah

From$80

Very Good 4.0 /5 Reviews Call BookMore Details

Courtyard by Marriott Paducah - Paducah

+1-800-805-5223

3835 Technology Dr., Paducah, KY 42001 ~28.32 miles east of Cairo

Affordable Suburban hotel
100 rooms in property

Exterior of Courtyard by Marriott Paducah

From$89

Very Good 4.0 /5 Latest Reviews Call BookMore Details

Drury Inn Paducah - Paducah

+1-888-965-1860

3975 Hinkleville Rd., Paducah, KY 42001 ~28.73 miles east of Cairo

3-star Suburban property
Hotel has 113 rooms

Photo of Drury Inn Paducah

From$79

Very Good 4.5 /5 Guest Reviews Call BookMore Details

Candlewood Suites Cape Girardeau, an IHG Hotel

+1-888-788-5576

485 South Mount Auburn Rd., Cape Girardeau, MO 65703 ~28.78 miles northwest of Cairo

Inexpensive Highway hotel
85 suites in property

Exterior of Candlewood Suites Cape Girardeau, an IHG Hotel

From$69

Very Good 4.0 /5 Guest Reviews Call BookMore Details

Days Inn by Wyndham Paducah

+1-888-897-9207

3901 Hinkleville Rd., Paducah, KY 42001 ~28.78 miles east of Cairo

Low Cost Highway hotel
2 floors in hotel

Image of Days Inn by Wyndham Paducah

From$50

Average 3.0 /5 Guest Reviews Call BookMore Details

Quality Inn & Suites Metropolis I-24 - Metropolis

+1-888-311-4278

2118 East 5th St., Metropolis, IL 62960 ~28.90 miles east of Cairo

Three Star hotel
52 rooms in property

Photo of Quality Inn & Suites Metropolis I-24

From$80

Very Good 4.0 /5 Reviews Call BookMore Details

Super 8 by Wyndham Metropolis in Metropolis

+1-888-469-4795

2055 East 5th St., Metropolis, IL 62960 ~28.91 miles east of Cairo

Cheap Highway property
63 rooms in hotel

Exterior of Super 8 by Wyndham Metropolis

From$60

Average 3.0 /5 Hotel Reviews Call BookMore Details

Travelers Inn and Suites

+1-888-734-9421

2550 Lone Oak Rd., Paducah, KY 42003 ~28.91 miles east of Cairo

2 star property
30 suites in hotel

Exterior of Travelers Inn and Suites

From$38

Very Good 4.0 /5 Hotel Reviews Call BookMore Details

Motel 6 Metropolis Il - Metropolis

+1-888-841-5292

2119 East 5th St., Metropolis, IL 62960 ~29.06 miles east of Cairo

Economical hotel
Check in: 11:00 AM

From$60

Average 3.0 /5 Read Reviews Call BookMore Details

Holiday Inn Express Metropolis, an IHG Hotel in Metropolis

+1-888-455-5160

2179 East 5th St., Metropolis, IL 62960 ~29.12 miles east of Cairo

Three Star Rural property
21 suites in property

Photo of Holiday Inn Express Metropolis, an IHG Hotel

From$65

Very Good 4.0 /5 Recent Reviews Call BookMore Details

Hampton Inn Cape Girardeau I 55 East

+1-888-965-8297

207 South Mount Auburn Rd., Cape Girardeau, MO 63703 ~29.42 miles northwest of Cairo

3-star Highway property
4 floors in hotel

Image of Hampton Inn Cape Girardeau I 55 East

From$80

Excellent 5.0 /5 Recent Reviews Call BookMore Details

Victorian Inn & Suites : 3256 William St.

+1-888-906-6358

3256 William St., Cape Girardeau, MO 63703 ~29.43 miles northwest of Cairo

3-star Golf Course property
133 sleeping rooms in hotel

From$79

Average 3.0 /5 Reviews Call BookMore Details

Auburn Place Hotel & Suites in Cape Girardeau

+1-888-749-6785

3265 Williams St., Cape Girardeau, MO 63702 ~29.44 miles northwest of Cairo

Mid-scale Highway hotel
2 conference rooms in property

Image of Auburn Place Hotel & Suites

From$58

Very Good 4.5 /5 Latest Reviews Call BookMore Details

Holiday Inn Express & Suites Cape Girardeau I 55 in Cape Girardeau

+1-888-878-9982

3253 William St., Cape Girardeau, MO 63701 ~29.51 miles northwest of Cairo

Mid-scale hotel
Gym is available on property

Image of Holiday Inn Express & Suites Cape Girardeau I 55

From$80

Very Good 4.5 /5 Review Score Call BookMore Details

Next: See My Cairo Hotels with Pricing

Graph: Upcoming 20 Days of Cairo Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Cairo, IL discounts available. The chart reflects the cheapest Cairo hotel for each day and each star rating category.

FAQs about hotels in Cairo

What are the most favored hotels in Cairo?

Hampton Inn Cape Girardeau I 55 East, Drury Inn & Suites Sikeston and Drury Inn Paducah are the best rated hotels based on customer reviews in the last 365 days.

What are the most luxurious hotels in Cairo?

Harrah's Metropolis Hotel & Casino, Quality Inn Cairo I-57 and Travel Inn & Suites - Sikeston are the top 3 luxury hotels near Cairo city center.

What hotels are closest to the city center of Cairo?

Quality Inn Cairo I-57, Super 8 by Wyndham Charleston, and Quality Inn Charleston - Sikeston are the properties closest to Cairo city center.

What are the best independent hotels in Cairo?

Auburn Place Hotel & Suites, Travel Inn & Suites - Sikeston and Harrah's Metropolis Hotel & Casino are the best rated independent hotels (not part of a big brand).

What are the most popular Marriott hotels in Cairo?

Residence Inn by Marriott Paducah, Courtyard by Marriott Cape Girardeau Downtown and Fairfield Inn & Suites by Marriott Paducah are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best Choice Hotels branded hotels in Cairo?

Comfort Inn & Suites near Six Flags, Comfort Inn Paducah and Quality Inn & Suites Metropolis I-24 are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the best IHG hotels in Cairo?

Holiday Inn Express & Suites Cape Girardeau I 55, Candlewood Suites Paducah, an IHG Hotel and Candlewood Suites Cape Girardeau, an IHG Hotel are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

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