Desoto Missouri Accommodations

Find hotels in Desoto using the list and search tools below. Search for the cheapest discounted hotel and motel rates in or near Desoto, MO for your corporate or personal leisure travel. We show the best Desoto Missouri hotel rooms. Review the Desoto hotel list below to find the perfect lodging. We also have a map of the Desoto hotels.

Desoto Hotels/Accommodations

Holiday Inn Club Vac Timber Creek in Desoto
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
4800 Us Highway 67, Desoto, MO 63020 +1-888-389-4121
  • 3-star hotel
  • 72 rooms in hotel
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From£69
Very good 4.5 /5 Latest Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites Festus South St. Louis An I - Festus
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
1802 Gamel Cemetery Rd., Festus, MO 63028 +1-888-675-2083 ~9.29 miles northeast of Desoto
  • Low Cost Highway hotel
  • Check in: 3:00pm
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From£69
Very good 4.0 /5 Reviews Call BookMore Details
Comfort Inn Festus - St Louis South
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
1303 Veterans Blvd., Festus, MO 63028 Website +1-800-716-8490 ~9.49 miles northeast of Desoto
  • 3-star Suburban hotel
  • Check in time: 3:00 PM
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From£34
Very good 4.0 /5 Reviews Call BookMore Details
Quality Inn Festus - Festus
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
1200 West Gannon Dr., Festus, MO 63028 Website +1-800-805-5223 ~9.52 miles northeast of Desoto
  • Mid-scale Suburban hotel
  • Access to gym on-site
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From£55
Average 3.0 /5 Recent Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Festus - St. Louis South - Festus
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
1001 Veterans Blvd., Festus, MO 63028 +1-888-965-1860 ~9.71 miles northeast of Desoto
  • Mid-scale Suburban property
  • Check in: 3:00 PM
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From£61
Average 3.0 /5 Reviews Call BookMore Details
Super 8 by Wyndham Pevely
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
1711 Highway Z, Pevely, MO 63070 +1-888-788-5576 ~13.04 miles northeast of Desoto
  • Low-priced hotel
  • Check-in: 11:00 AM
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From£27
Very good 4.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Bonne Terre
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
8 Northwood Dr., Bonne Terre, MO 63628 +1-888-897-9207 ~14.95 miles south of Desoto
  • Economy hotel
  • Check-in: 11:00 AM
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From£46
Average 3.0 /5 Hotel Reviews Call BookMore Details
Motel 6 Bonne Terre Mo
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
1017 Highway K, Bonne Terre, MO 63628 +1-888-311-4278 ~15.14 miles south of Desoto
  • Economical property
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From£46
Average 3.0 /5 Read Reviews Call BookMore Details
Super 8 by Wyndham Potosi - Potosi
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
820 East High St., Potosi, MO 63664 +1-888-469-4795 ~18.93 miles southwest of Desoto
  • 2 star Highway property
  • Check in time: 2 pm
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From£37
Average 3.0 /5 Latest Reviews Call BookMore Details
Quality Inn & Suites - Arnold
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
3610 West Outer Rd., Arnold, MO 63010 Website +1-888-734-9421 ~20.99 miles northeast of Desoto
  • 2-star Suburban property
  • 2 meeting rooms in property
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From£46
Average 3.0 /5 Recent Reviews Call BookMore Details
Woodspring Suites St. Louis Arnold : 888 Arnold Commons Dr.
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
888 Arnold Commons Dr., Arnold, MO 63010 +1-888-841-5292 ~22.48 miles northeast of Desoto
  • Low-priced Highway hotel
  • 4 floors in property
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From£24
Very good 4.0 /5 Guest Reviews Call BookMore Details
Drury Inn & Suites St. Louis Arnold
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
3800 State Rt 141, Arnold, MO 63010 +1-888-455-5160 ~22.60 miles northeast of Desoto
  • 3-star Suburban hotel
  • Fitness + Health Center
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From£95
Excellent 5.0 /5 Reviews Call BookMore Details
Pear Tree Inn St. Louis Arnold - Arnold
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
1201 Drury Lane, Arnold, MO 63010 +1-888-965-8297 ~23.18 miles northeast of Desoto
  • 3 star Suburban property
  • Comp. Breakfast
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From£61
Very good 4.0 /5 Recent Reviews Call BookMore Details
Crown Pointe Lodge, BW Signature Collection
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
4245 Hunt Rd., Farmington, MO 63640 +1-888-906-6358 ~23.30 miles south of Desoto
  • Three Star Golf Course property
  • 3 floors in property
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From£50
Very good 4.0 /5 Read Reviews Call BookMore Details
Best Western St. Louis Inn : 6224 Heimos Industrial Park Dr.
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
6224 Heimos Industrial Park Dr., Saint Louis, MO 63129 +1-888-749-6785 ~24.45 miles northeast of Desoto
  • 2 star Suburban hotel
  • Free breakfast available
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From£31
Average 3.0 /5 Guest Reviews Call BookMore Details
Hampton Inn Farmington in Farmington
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
850 Valley Creek Dr., Farmington, MO 63640 +1-888-878-9982 ~24.74 miles south of Desoto
  • Midscale Highway hotel
  • Fitness + Health Center
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From£61
Average 3.0 /5 Hotel Reviews Call BookMore Details
Super 8 by Wyndham Farmington - Farmington
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
930 Valley Creek Dr., Farmington, MO 63640 +1-888-389-4485 ~24.81 miles south of Desoto
  • Inexpensive hotel
  • Complimentary breakfast is offered
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From£37
Average 3.0 /5 Recent Reviews Call BookMore Details
Holiday Inn Express & Suites Farmington by IHG - Farmington
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
820 Market St., Farmington, MO 63640 +1-888-389-4121 ~24.84 miles south of Desoto
  • Mid-scale Rural property
  • 20 suites in property
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From£76
Very good 4.0 /5 Latest Reviews Call BookMore Details
680 Fenton Business Park Ct Fenton Missouri 63026 : Fenton Business Park Court Fenton
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
Fenton Business Park Court Fenton, Fenton, IA 63026 +1-888-675-2083 ~25.52 miles north of Desoto
  • Three Star hotel
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From£61
Average 3.0 /5 Recent Reviews Call BookMore Details
Quality Inn Farmington
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
1400 West Liberty St., Farmington, MO 63640 +1-800-716-8490 ~25.67 miles south of Desoto
  • 3-star Rural hotel
  • Check in time: 11:00
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From£61
Average 3.0 /5 Review Score Call BookMore Details
America's Best Inn Eureka - Eureka
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
1725 West 5th St., Eureka, MO 63025 +1-800-805-5223 ~25.91 miles north of Desoto
  • Low-priced Highway property
  • Check in: 11.00am
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From£46
Poor 2.0 /5 Read Reviews Call BookMore Details
Super 8 by Wyndham Eureka/Six Flags Nearby
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
1733 West 5th St., Eureka, MO 63025 +1-888-965-1860 ~25.97 miles north of Desoto
  • Low-priced Highway hotel
  • Check-in: ex. 3:00 PM
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From£46
Average 3.0 /5 Review Score Call BookMore Details
Baymont Inn and Suites by Wyndham Farmington, MO : 1625 West Columbia St.
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
1625 West Columbia St., Farmington, MO 63640 +1-888-788-5576 ~26.01 miles south of Desoto
  • 3-star Highway hotel
  • Free breakfast available
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From£61
Average 3.0 /5 Review Score Call BookMore Details
Fairfield Inn N Ste St. Louis South
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
4318 Butler Hill Rd., St Louis, MO 63128 +1-888-897-9207 ~26.12 miles northeast of Desoto
  • Midscale hotel
  • Check-in: 15:00
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From£69
Average 3.0 /5 Latest Reviews Call BookMore Details
Holiday Inn Express & Suites St. Louis South - I-55 by IHG
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
4250 Midamerica Ln, St. Louis, MO 63129 +1-888-311-4278 ~26.15 miles northeast of Desoto
  • Mid-scale Suburban property
  • Hotel has a green policy See more
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From£61
Average 3.0 /5 Read Reviews Call BookMore Details
Quality Inn Near Six Flags St. Louis : 1400 West Osage St.
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
1400 West Osage St., Pacific, MO 63069 +1-888-469-4795 ~26.20 miles northwest of Desoto
  • Three Star Rural property
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From£61
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Hampton Inn & Suites St. Louis/South I-55 in St. Louis
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
4200 Midamerica Ln, St. Louis, MO 63129 +1-888-734-9421 ~26.21 miles northeast of Desoto
  • 3 star Suburban hotel
  • Check-in time: 3:00pm
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From£61
Very good 4.0 /5 Read Reviews Call BookMore Details
Comfort Inn Near Six Flags St. Louis : 1320 Thornton St.
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
1320 Thornton St., Pacific, MO 63069 Website +1-888-841-5292 ~26.31 miles northwest of Desoto
  • 3-star Highway hotel
  • 2 suites in property
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From£68
Average 3.0 /5 Latest Reviews Call BookMore Details
Holiday Inn St. Louis West Six Flags by IHG : 4901 Six Flags Rd.
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
4901 Six Flags Rd., Eureka, MO 63025 +1-888-455-5160 ~26.44 miles north of Desoto
  • 3-star Suburban hotel
  • 4 meeting rooms in property
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From£99
Average 3.0 /5 Recent Reviews Call BookMore Details
Super 8 by Wyndham Waterloo
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
112 Warren Dr., Waterloo, IL 62298 +1-888-965-8297 ~26.69 miles northeast of Desoto
  • Inexpensive Rural hotel
  • Complimentary breakfast is offered
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From£46
Average 3.5 /5 Review Score Call BookMore Details
Super 8 by Wyndham St. Clair MO in Saint Clair
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
1010 South Outer Rd., Saint Clair, MO 63077 +1-888-906-6358 ~27.54 miles northwest of Desoto
  • Low Cost Highway property
  • 51 rooms in property
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From£46
Average 3.0 /5 Read Reviews Call BookMore Details
Pinemark Inn & Suites
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
866 South Outer Rd., St. Clair, MO 63077 +1-888-749-6785 ~27.61 miles northwest of Desoto
  • Economy Highway property
  • 3 suites in property
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From£47
Very good 4.0 /5 Review Score Call BookMore Details
Hampton Inn St. Louis Southwest : 9 Lambert Drury Place
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
9 Lambert Drury Place, St. Louis, MO 63088 +1-888-878-9982 ~27.69 miles north of Desoto
  • 3 star Suburban hotel
  • Gym / Fitness Center Available
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From£65
Very good 4.5 /5 Hotel Reviews Call BookMore Details
Drury Inn & Suites St. Louis Southwest
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
5 Lambert Drury Place (I 44 & 141), St. Louis, MO 63088 +1-888-389-4485 ~27.70 miles north of Desoto
  • Midscale Suburban hotel
  • Check in: 3:00 PM
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From£65
Very good 4.5 /5 Reviews Call BookMore Details
Hampton Inn St. Louis Columbia in Columbia
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
165 Admiral Trost Dr., Columbia, IL 62236 +1-888-389-4121 ~27.77 miles northeast of Desoto
  • Three Star Suburban property
  • Check in: 3:00 PM
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From£61
Average 3.0 /5 Read Reviews Call BookMore Details
Holiday Inn Express St. Louis West Fenton - Fenton
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
1848 Bowles Ave., Fenton, MO 63026 +1-888-675-2083 ~28.01 miles north of Desoto
  • Three Star Suburban property
  • Fitness + Health Center
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From£61
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Motel 6 Fenton Mo in Fenton
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
1860 Bowles Ave., Fenton, MO 63026 +1-800-716-8490 ~28.03 miles north of Desoto
  • Low-priced hotel
  • Hotel has 58 rooms
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From£46
Average 3.0 /5 Guest Reviews Call BookMore Details
Wingate by Wyndham St. Louis / Fenton Route 66 - Fenton
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
1100 South Highway Dr., Fenton, MO 63026 +1-800-805-5223 ~28.15 miles north of Desoto
  • Midscale Suburban property
  • 3 floors in hotel
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From£61
Average 3.0 /5 Review Score Call BookMore Details
Heritage Inn & Suites St. Louis / Fenton Trademark by Wyndham : 1088 South Highway Dr.
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
1088 South Highway Dr., Fenton, MO 63026 +1-888-965-1860 ~28.20 miles north of Desoto
  • Three Star Suburban hotel
  • Free breakfast available
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From£61
Average 3.0 /5 Guest Reviews Call BookMore Details
Extended Stay America Suites St. Louis Fenton : 1662 Fenton Business Park Court
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
1662 Fenton Business Park Court, Fenton, MO 63026 +1-888-788-5576 ~28.29 miles north of Desoto
  • 3-star Suburban property
  • 94 rooms in hotel
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From£61
Average 3.0 /5 Latest Reviews Call BookMore Details
Americas Best Value Inn St. Louis South - St. Louis
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
6602 South Lindbergh Blvd., St. Louis, MO 63123 +1-888-897-9207 ~28.30 miles northeast of Desoto
  • Low-priced Suburban property
  • Check in time: 3:00 PM
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From£37
Poor 2.0 /5 Read Reviews Call BookMore Details
Best Western Plus Fenton
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
1680 Fenton Business Park Court, Fenton, MO 63026 +1-888-311-4278 ~28.36 miles north of Desoto
  • 3-star Suburban property
  • Fitness + Health Center
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From£50
Average 3.0 /5 Reviews Call BookMore Details
Super 8 by Wyndham Fenton/St. Louis Area
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
650 South Highway Dr., Fenton, MO 63026 +1-888-469-4795 ~28.38 miles north of Desoto
  • Inexpensive hotel
  • Check-in: 15:00
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From£46
Poor 2.0 /5 Read Reviews Call BookMore Details
Aviator Hotel & Suites : 6921 South Lindbergh Blvd.
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
6921 South Lindbergh Blvd., St Louis, MO 63125 +1-888-734-9421 ~28.39 miles northeast of Desoto
  • Midscale Suburban property
  • Hotel has 4 floors
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From£61
Average 3.0 /5 Hotel Reviews Call BookMore Details
Microtel Inn & Suites by Wyndham Sainte Genevieve
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
21958 Highway 32, Sainte Genevieve, MO 63670 +1-888-841-5292 ~29.61 miles east of Desoto
  • Cheap Highway hotel
  • 6 suites in property
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From£58
Very good 4.0 /5 Latest Reviews Call BookMore Details
Days Inn by Wyndham St. Louis Lindbergh Boulevard
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
3660 South Lindbergh Blvd., St Louis, MO 63127 +1-888-455-5160 ~29.65 miles north of Desoto
  • Three Star Suburban hotel
  • Hotel has a green policy See policy
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From£53
Average 3.0 /5 Recent Reviews Call BookMore Details
Holiday Inn St. Louis Sw Route 66 An Ihg Hotel
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
10709 Watson Rd., St. Louis, MO 63127 +1-888-965-8297 ~29.82 miles north of Desoto
  • Affordable Suburban hotel
  • 12 suites in hotel
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From£61
Average 3.0 /5 Review Score Call BookMore Details
La Quinta Inn & Suites by Wyndham - Saint Louis
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
1580 South Kirkwood Rd., Saint Louis, MO 63127 +1-888-906-6358 ~29.89 miles north of Desoto
  • Midscale Suburban hotel
  • Free complimentary breakfast
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From£77
Average 3.0 /5 Hotel Reviews Call BookMore Details
Best Western St. Louis Kirkwood Route 66 in Saint Louis
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
1200 South Kirkwood Rd., Saint Louis, MO 63122 +1-888-749-6785 ~30.33 miles north of Desoto
  • 3 star Suburban property
  • Free breakfast available
More Photos
From£54
Very good 4.0 /5 Read Reviews Call BookMore Details
The Wildwood Hotel in Wildwood
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
2801 Fountain Place, Wildwood, MO 63040 +1-888-878-9982 ~30.80 miles north of Desoto
  • High end Suburban property
  • 5 floors in hotel
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From£77
Very good 4.0 /5 Recent Reviews Call BookMore Details

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