Find hotels in Desoto using the list and search tools below. Search for the cheapest discounted hotel and motel rates in or near Desoto, MO for your corporate or personal leisure travel. We show the best Desoto Missouri hotel rooms. Review the Desoto hotel list below to find the perfect lodging. We also have a map of the Desoto hotels.
How should we direct your call?
Book online or call +1-800-219-2797
Drury Inn & Suites St. Louis Arnold, Holiday Inn Club Vac Timber Creek and Hampton Inn St. Louis Southwest are the best rated hotels based on customer reviews in the last 365 days.
The Wildwood Hotel, Holiday Inn Club Vac Timber Creek and Comfort Inn Festus - St Louis South are the top 3 luxury hotels near Desoto city center.
Holiday Inn Club Vac Timber Creek, Holiday Inn Express Hotel & Suites Festus South St. Louis An I, and Comfort Inn Festus - St Louis South are the properties closest to Desoto city center.
Pinemark Inn & Suites, The Wildwood Hotel and America's Best Inn Eureka are the best rated independent hotels (not part of a big brand).
Fairfield Inn N Ste St. Louis South and Fairfield by Marriott are the best rated Marriott/Starwood branded hotels (based on customer reviews score).
Comfort Inn Festus - St Louis South, Woodspring Suites St. Louis Arnold and Quality Inn Near Six Flags St. Louis are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).
Crown Pointe Lodge, BW Signature Collection, Best Western St. Louis-Kirkwood Route 66 and Best Western St. Louis Inn are the best rated Best Western branded hotels (based on user reviews score).
Holiday Inn Club Vac Timber Creek, Holiday Inn Express Hotel & Suites Festus South St. Louis An I and Holiday Inn Express & Suites Farmington, an IHG Hotel are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).