Seneca South Carolina Hotels & Motels

Only hotels in Seneca are listed below. Search for cheap and discounted hotel and motel rates in or near Seneca, SC for your upcoming personal or group trip. We provide the best Seneca, South Carolina motel and hotel rooms. Browse the Seneca area hotels to find the perfect lodging! Please use the provided map of the Seneca hotels. Group booking? Search Seneca Group Hotel Discounts

The Seneca center point is about 6 miles west of Memorial Stadium and 6 miles west of Clemson Amtrak Station.

Known for its friendly atmosphere and small-town charm, Seneca, South Carolina, is just 10 miles west of Clemson. Whether you're visiting for work or fun, you'll appreciate the city's welcoming vibe, historic district, and beautiful setting. Get to know the City of Smiles and find out where to stay in Seneca. More from this guide...

Seneca Hotels/Accommodations

Best Western Seneca-Clemson : 511 Bypass Highway 123
+1-888-389-4121
511 Bypass Highway 123, Seneca, SC 29678 +1-888-389-4121
  • Midscale Rural property
  • Free complimentary breakfast
From$99
Very Good 4.0 /5 Reviews Call BookMore Details
Fairfield Inn & Suites by Marriott Seneca Clemson Univ Area : 800 Us 123
+1-888-675-2083
800 Us 123, Seneca, SC 29678 +1-888-675-2083
  • 2 star Rural hotel
  • Hotel has 102 rooms
From$60
Average 3.0 /5 Reviews Call BookMore Details
Hampton Inn & Suites Seneca Clemson Area Sc : 1011 East North 1st St.
+1-800-716-8490
1011 East North 1st St., Seneca, SC 29678 +1-800-716-8490
  • Three Star hotel
  • 100 sleeping rooms in hotel
From$129
Very Good 4.5 /5 Reviews Call BookMore Details
Days Inn by Wyndham Seneca / Clemson Area : 11015 North Radio Station Rd.
+1-800-805-5223
11015 North Radio Station Rd., Seneca, SC 29678 +1-800-805-5223
  • 2 star property
  • Check-in: 2:00
From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Quality Inn Seneca US-123 : 226 Hitec Rd.
+1-888-965-1860
226 Hitec Rd., Seneca, SC 29678 +1-888-965-1860
  • 3-star Lake property
  • Free comp. breakfast
From$76
Very Good 4.0 /5 Guest Reviews Call BookMore Details
TRU by Hilton Seneca Clemson
+1-888-788-5576
13050 Clemson Blvd., Seneca, SC 29678 +1-888-788-5576
  • Three Star Lake hotel
  • Check-in: 3:00pm
From$59
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Hampton Inn - Clemson
+1-888-897-9207
851 Tiger Blvd., Clemson, SC 29631 +1-888-897-9207 ~5.99 miles east of Seneca
  • Mid-scale Suburban hotel
  • 4 floors in hotel
From$104
Very Good 4.0 /5 Read Reviews Call BookMore Details
Holiday Inn Express & Suites (Clemson University & Seneca Area) : 1381 Tiger Blvd.
+1-888-311-4278
1381 Tiger Blvd., Clemson, SC 29631 +1-888-311-4278 ~6.80 miles east of Seneca
  • Three Star Downtown hotel
  • Hotel has a green policy Learn more
From$109
Very Good 4.5 /5 Reviews Call BookMore Details
Inn at Clemson
+1-888-469-4795
1303 Tiger Blvd., Clemson, SC 29631 +1-888-469-4795 ~6.80 miles east of Seneca
  • 2-star hotel
  • Check in: 3.00PM
From$76
Very Good 4.0 /5 Read Reviews Call BookMore Details
Days Inn by Wyndham Clemson
+1-888-734-9421
1387 Tiger Blvd., Clemson, SC 29631 +1-888-734-9421 ~6.80 miles east of Seneca
  • Cheap property
  • 46 rooms in hotel
From$59
Average 3.0 /5 Guest Reviews Call BookMore Details
Comfort Inn & Suites Clemson - University Area : 1305 Tiger Blvd.
+1-888-841-5292
1305 Tiger Blvd., Clemson, SC 29631 +1-888-841-5292 ~7.12 miles east of Seneca
  • 3 star Downtown hotel
  • 2 meeting rooms in hotel
From$80
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Best Western Plus Clemson Hotel & Conference Center : 1310 Tiger Blvd.
+1-888-455-5160
1310 Tiger Blvd., Clemson, SC 29631 +1-888-455-5160 ~7.28 miles east of Seneca
  • Economy Downtown hotel
  • Fitness center on property
From$84
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Rodeway Inn & Suites in Walhalla
+1-888-965-8297
901 East Main St., Walhalla, SC 29691 +1-888-965-8297 ~7.87 miles northwest of Seneca
  • Economy Mountain property
  • Check-in: 02:00 PM
From$50
Very Good 4.0 /5 Read Reviews Call BookMore Details
Courtyard Marriott Clemson : 201 Canoy Lane
+1-888-906-6358
201 Canoy Lane, Clemson, SC 29631 +1-888-906-6358 ~7.93 miles east of Seneca
  • Mid-scale hotel
  • Fitness center on property
From$114
Very Good 4.0 /5 Review Score Call BookMore Details
Econo Lodge in Clemson
+1-888-749-6785
106 Liberty Dr., Clemson, SC 29631 +1-888-749-6785 ~8.08 miles east of Seneca
  • Low Cost hotel
From$60
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
The Inn at Patrick Square in Clemson
+1-888-878-9982
115 Market St., Clemson, SC 29631 +1-888-878-9982 ~9.47 miles east of Seneca
  • Mid-scale Suburban property
  • 45 rooms in property
From$80
Average 3.0 /5 Reviews Call BookMore Details
Hampton Inn Anderson - Anderson
+1-888-389-4485
120 Insterstate Blvd., Anderson, SC 29621 +1-888-389-4485 ~13.07 miles southeast of Seneca
  • Midscale Highway property
  • 2 suites in property
From$84
Average 3.0 /5 Reviews Call BookMore Details
Microtel Inn & Suites by Wyndham Anderson/Clemson
+1-888-389-4121
102 Electric City Blvd., Anderson, SC 29621 +1-888-389-4121 ~15.54 miles east of Seneca
  • Cheap Highway hotel
  • 16 suites in hotel
From$58
Average 3.0 /5 Hotel Reviews Call BookMore Details
Country Inn & Suites by Radisson, Anderson, SC
+1-888-675-2083
116 Interstate Blvd., Anderson, SC 29621 +1-888-675-2083 ~15.61 miles east of Seneca
  • Midscale Highway property
  • Comp. Breakfast
From$65
Very Good 4.0 /5 Review Score Call BookMore Details
Fairfield Inn & Suites by Marriott Anderson Clemson
+1-800-716-8490
117 Interstate Blvd., Anderson, SC 29621 +1-800-716-8490 ~15.61 miles east of Seneca
  • Affordable property
  • 3 floors in property
From$90
Very Good 4.0 /5 Review Score Call BookMore Details
Holiday Inn Express & Suites
+1-800-805-5223
107 Interstate Blvd., Anderson, SC 29621 +1-800-805-5223 ~15.64 miles east of Seneca
  • Affordable Highway hotel
  • Check in: 3:00PM
From$80
Very Good 4.0 /5 Reviews Call BookMore Details
Comfort Suites Anderson-Clemson
+1-888-965-1860
118 Interstate Blvd., Anderson, SC 29621 Website +1-888-965-1860 ~15.73 miles east of Seneca
  • 2-star Highway hotel
  • Check-in time: 3:00pm
From$64
Average 3.0 /5 Review Score Call BookMore Details
Rodeway Inn in Anderson
+1-888-788-5576
4515 Clemson Blvd., Anderson, SC 29621 +1-888-788-5576 ~15.94 miles southeast of Seneca
  • Low Cost hotel
  • 50 sleeping rooms in hotel
From$60
Very Good 4.0 /5 Read Reviews Call BookMore Details
Baymont by Wyndham Anderson Clemson
+1-888-897-9207
128 Interstate Blvd., Anderson, SC 29621 +1-888-897-9207 ~15.97 miles east of Seneca
  • Cheap Highway property
  • Check-in time: 03:00pm
From$50
Average 3.0 /5 Read Reviews Call BookMore Details
Days Inn by Wyndham Anderson - Anderson
+1-888-311-4278
1007 Smith Mill Rd., Anderson, SC 29625 +1-888-311-4278 ~16.04 miles southeast of Seneca
  • Economy Highway property
  • Check in time: 11:00 AM
From$50
Average 3.0 /5 Reviews Call BookMore Details
Hilton Garden Inn Anderson in Anderson
+1-888-469-4795
115 Destination Blvd., Anderson, SC 29621 +1-888-469-4795 ~16.11 miles southeast of Seneca
  • Three Star Highway hotel
  • Check-in time: 3:00PM
From$80
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Americas Best Value Inn Anderson, SC
+1-888-734-9421
4020 Clemson Blvd., Anderson, SC 29621 +1-888-734-9421 ~17.45 miles southeast of Seneca
  • Economical Suburban property
  • 2 floors in hotel
From$53
Average 3.0 /5 Reviews Call BookMore Details
Holiday Inn Anderson, an IHG Hotel : 3509 Clemson Blvd.
+1-888-841-5292
3509 Clemson Blvd., Anderson, SC 29621 +1-888-841-5292 ~18.40 miles southeast of Seneca
  • 3-star Downtown hotel
  • Hotel has 2 meeting rooms
From$85
Very Good 4.5 /5 Recent Reviews Call BookMore Details
Super 8 by Wyndham Anderson/Clemson Area
+1-888-455-5160
3302 Cinema Ave., Anderson, SC 29621 +1-888-455-5160 ~18.57 miles southeast of Seneca
  • Economical property
From$60
Average 3.5 /5 Read Reviews Call BookMore Details
Quality Inn Clemson Near University
+1-888-965-8297
3430 Clemson Blvd., Anderson, SC 29621 +1-888-965-8297 ~18.61 miles southeast of Seneca
  • Economy Suburban property
  • 2 floors in property
From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Days Inn by Wyndham Lavonia
+1-888-906-6358
13705 Jones St., Lavonia, GA 30553 +1-888-906-6358 ~19.09 miles southwest of Seneca
  • Economical Highway property
  • Free complimentary breakfast
From$60
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Lavonia : 14227 Jones St.
+1-888-749-6785
14227 Jones St., Lavonia, GA 30553 +1-888-749-6785 ~19.12 miles southwest of Seneca
  • Cheap Highway hotel
From$60
Average 3.0 /5 Reviews Call BookMore Details
Quality Inn in Lavonia
+1-888-878-9982
890 Ross Place, Lavonia, GA 30553 +1-888-878-9982 ~19.18 miles southwest of Seneca
  • Cheap hotel
  • 65 rooms in hotel
From$43
Average 3.0 /5 Hotel Reviews Call BookMore Details
Horizon Inn & Suites in Anderson
+1-888-389-4485
3025 North Main St., Anderson, SC 29621 +1-888-389-4485 ~19.24 miles southeast of Seneca
  • Two-star Downtown property
  • 2 floors in property
From$60
Average 3.0 /5 Read Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites Lavonia, an IHG Hotel in Lavonia
+1-888-389-4121
110 Owens Dr., Lavonia, GA 30553 +1-888-389-4121 ~19.25 miles southwest of Seneca
  • 3 star Rural hotel
  • Hotel has an eco-friendly policy Read more
From$110
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Hampton Inn & Suites Lavonia
+1-888-675-2083
115 Owens Dr., Lavonia, GA 30553 +1-888-675-2083 ~19.32 miles southwest of Seneca
  • 3 star Rural hotel
  • Gym / Fitness Center Available
From$110
Very Good 4.0 /5 Read Reviews Call BookMore Details
Holiday Inn Express Anderson An Ihg Hotel in Anderson
+1-800-716-8490
410 Alliance Pkwy., Anderson, SC 29621 +1-800-716-8490 ~20.49 miles east of Seneca
  • Cheap Highway property
  • Gym / Fitness Center Available
From$60
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Hampton Inn Anderson/ Alliance Business Park in Anderson
+1-800-805-5223
411 Alliance Pkwy., Anderson, SC 29621 +1-800-805-5223 ~20.50 miles east of Seneca
  • Two star Highway hotel
  • Fitness + Health Center
From$85
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Quality Inn
+1-888-965-1860
106 Stephen Circle, Toccoa, GA 30577 +1-888-965-1860 ~21.80 miles west of Seneca
  • Low Cost Downtown property
  • Gym / Fitness Center Available
From$49
Average 3.0 /5 Review Score Call BookMore Details
Country Hearth Inn & Suites Toccoa in Toccoa
+1-888-788-5576
273 North Brd. St., Toccoa, GA 30577 +1-888-788-5576 ~22.81 miles west of Seneca
  • Low-priced hotel
  • Free complimentary breakfast
From$53
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Hampton Inn Hartwell : 1357 East Franklin St.
+1-888-897-9207
1357 East Franklin St., Hartwell, GA 30643 +1-888-897-9207 ~22.96 miles south of Seneca
  • 3-star Rural property
  • Hotel has 9 suites
From$98
Very Good 4.0 /5 Review Score Call BookMore Details
Quality Inn Hartwell in Hartwell
+1-888-311-4278
1091 East Franklin St., Hartwell, GA 30643 +1-888-311-4278 ~22.98 miles south of Seneca
  • Affordable Downtown property
  • 2 floors in hotel
From$61
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Days Inn by Wyndham Easley/Greenville/Clemson Area : 121 Days Inn Dr.
+1-888-469-4795
121 Days Inn Dr., Easley, SC 29640 +1-888-469-4795 ~23.82 miles east of Seneca
  • Cheap Downtown property
  • Free breakfast
From$40
Average 3.0 /5 Recent Reviews Call BookMore Details
Quality Inn & Suites
+1-888-734-9421
5539 Calhoun Memorial Highway, Easley, SC 29640 Website +1-888-734-9421 ~23.96 miles east of Seneca
  • Cheap hotel
  • Hotel has 86 rooms
From$69
Average 3.0 /5 Hotel Reviews Call BookMore Details
Baymont by Wyndham Easley/Greenville : 211 Dayton School Rd.
+1-888-841-5292
211 Dayton School Rd., Easley, SC 29642 +1-888-841-5292 ~24.56 miles east of Seneca
  • Low Cost Highway property
  • Fitness / Gym is on-site
From$62
Average 3.0 /5 Review Score Call BookMore Details
Hampton Inn Easley
+1-888-455-5160
8 Southern Center Court, Easley, SC 29642 +1-888-455-5160 ~25.79 miles east of Seneca
  • Affordable Suburban hotel
  • Free comp. breakfast
From$99
Very Good 4.5 /5 Latest Reviews Call BookMore Details
Kingwood Resort
+1-888-965-8297
401 Country Club Dr., Clayton, GA 30525 +1-888-965-8297 ~26.30 miles west of Seneca
  • 3-star Resort property
  • 48 rooms in property
From$79
Very Good 4.0 /5 Reviews Call BookMore Details
Super 8 by Wyndham Piedmont Greenville Area - Piedmont
+1-888-906-6358
3104 Highway 153, Piedmont, SC 29673 +1-888-906-6358 ~28.23 miles east of Seneca
  • 2 star Highway hotel
  • 46 rooms in hotel
From$60
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Best Western Plus Greenville South
+1-888-749-6785
70 Kalyns Way, Piedmont, SC 29673 +1-888-749-6785 ~28.32 miles east of Seneca
  • Midscale Highway property
  • Hotel has 60 rooms
From$73
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Comfort Suites Greenville South
+1-888-878-9982
10 Kalyns Way, Piedmont, SC 29673 Website +1-888-878-9982 ~28.33 miles east of Seneca
  • Three Star Highway property
  • Fitness + Health Center
From$69
Very Good 4.0 /5 Recent Reviews Call BookMore Details

Next: See My Seneca Hotels with Pricing

When should you visit Seneca, SC?

To experience the city at its liveliest, don't miss Seneca Fest. This annual event takes place at the end of May and features a full lineup of musical performances, action-packed wrestling matches, and family-friendly activities.

To plan your trip around the area's best weather, consider visiting during the spring or fall when high temperatures usually top out in the low 80s or high 70s. Summers can get very hot in Seneca, with highs in the 90s, and winters can get chilly, with lows around 30. Although August tends to be the wettest month of the year, winter is rainy season in Seneca. If you visit during the winter, bundle up and wear a waterproof jacket to stay warm and dry.

Winter is low season in Seneca, and you're most likely to find great discounts on hotels in January or February. For low rates on accommodations during high season, start planning in advance, and look for group rates.

What hotels in Seneca, SC offer the best discounts?

Looking for the best deals and discounts on Seneca hotels? Browse some of the best group rates in the area.

Senior travelers and AARP members can get discounts at the Best Western Executive Inn in Seneca. This centrally located hotel has both suites and standard rooms, and you'll appreciate the outdoor pool and the complimentary breakfast served each morning.

AAA members can get low rates at the Baymont Inn & Suites in Anderson. This mid-range hotel has a long list of extras, including free breakfast, a fitness center, an outdoor pool, and a meeting room available for reservation.

Government employees and members of the military can save at the Rodeway Inn in nearby Anderson. This budget-friendly hotel has 50 affordable rooms with basics like mini-fridges, microwaves, and coffee makers, and the hotel offers easy access to Interstate 85.

Where are the hotels with the most value in Seneca, South Carolina

It's easy to balance price with amenities when you book one of the best value options in Seneca. Take a look at the area's best mid-range hotels.

When you want to stay in the heart of Seneca, the Quality Inn offers plenty of value in a convenient location. This mid-range hotel has over 60 well-equipped guest rooms, along with a fitness center, an outdoor pool, and free Wi-Fi. You'll love the signature Q Beds, and after a great night's sleep, you'll be ready to dig into the complimentary breakfast spread. This Quality Inn welcomes up to two pets per room, making it easy to travel with your furry family members.

Nestled in nearby Clemson, the Best Western Plus University Inn & Conference Center is a smart choice for both leisure and business travelers. Settle into your modern guest room, grab a bite to eat at the full-service restaurant, and catch up on work in the business center. This Best Western also has six available conference rooms and an average group discount of over 20 percent, making this mid-range hotel excellent for groups visiting the Seneca area.

Also located in Clemson, Comfort Inn Clemson SC (Clemson University & Seneca Area) features three meeting rooms and an average group discount of over 15 percent. This mid-range hotel has guest rooms equipped with microwaves, coffee makers, and mini-fridges as well as an outdoor pool that's ideal for cooling off on a hot summer day. In the morning, don't miss the free breakfast bar, which includes biscuits and gravy, fresh waffles, pastries, and coffee.

What can't-miss attractions should you see in Seneca, SC?

With its equal doses of historical charm and natural beauty, Seneca has a little something for every visitor. Take a stroll through the Seneca Historic District to enjoy this South Carolina gem's small-town appeal and marvel at the many homes and churches that date back to the 19th century.

Located in the heart of the Seneca Historic District, the Lunney House Museum is an essential stop for history buffs. A stunning example of the architecture that defined the New South in the early 20th century, this home features impressive details like a sparkling chandelier, an intricately carved oak mantel, a 19th-century grand piano, and art glass windows. Take a self-guided tour of the house museum or check the museum's calendar for special events.

To gain a more comprehensive picture of Seneca's history, you'll also want to visit the Bertha Lee Strickland Cultural Museum. This fascinating museum explores the history of African-American culture and Oconee County residents through a variety of permanent and temporary exhibitions.

If you're traveling with kids in tow, you'll also want to visit the World of Energy at Oconee Nuclear. This interactive museum is a fun place for kids of all ages to learn about electricity, energy, and local nature and wildlife.

Next, experience Seneca's natural beauty firsthand with a visit to South Cove County Park. Located on the shores of Lake Keowee, this park is perfect for swimming, sunbathing, boating, and fishing. You can also take advantage of the tennis courts, picnic areas, and playgrounds all year round. If you didn't bring your own boat, you'll find canoe, kayak, and pontoon boat rentals at Lake Keowee Marina and many other local spots.

Why wait to book your trip? Find the ideal place to stay and start designing your Seneca itinerary.

What did travelers think of the city of Seneca?

Below are reviews of the city of Seneca, SC from an actual visitor's perspective.

"The View!"
Score 4.0 / 5

The view!

Tammy S., from 25-Jun-2024
"Beautiful Water Views!"
Score 5.0 / 5

Beautiful views of water!

Tammy S., from 25-Jun-2024
"Convenient to Shops & Restaurants"
Score 5.0 / 5

The shops and restaurants being close to the hotel was very convenient.

Kristin M., from 23-Jun-2024
"Nostalgic Drive-In and Jazz"
Score 5.0 / 5

We were given a recommendation for a great burger joint. Time Drive-In! Suggest y'all check it out. It was a throw back to when burgers were good and service meant something! Seneca is a fun town to walk in the downtown area, lots to see. Thursday night jazz was fun.

Kelly J., from 16-Jun-2024
"Nice City"
Score 5.0 / 5

It's a nice city.

Richard S., from 17-Dec-2023
"Nice town and great restaurant!"
Score 5.0 / 5

Nice and clean little town and a great restaurant, Seneca family restaurant.

Warren C., from 14-Oct-2023
"Good Location"
Score 5.0 / 5

The hotel was easy to find.

Dwight H., from 29-Sep-2023
"Great Places to Eat!"
Score 4.0 / 5

Friendly people and great places to eat. Example, Blue Marble Deli and Tipsy Taco.

Andrew S., from 14-May-2023
"Very Pretty Area"
Score 5.0 / 5

Very pretty area!

Debora L., from 15-Apr-2023
"Nice Place & Good Restaurants"
Score 5.0 / 5

Nice place to visit. Good restaurants.

Barry P., from 27-Mar-2023
"Nice Small Town "
Score 5.0 / 5

Seneca is a very nice small town. It has what you need for a short visit.

Jerry A., from 21-Mar-2023
"Nice Place"
Score 4.0 / 5

Nice place and good place to visit.

Peter B., from 15-Oct-2022
"Central to Lake Hartwell, Lake Jocassee & Lake Keowee"
Score 4.0 / 5

The main reason I like Seneca is the city's central proximity to Lake Hartwell, Lake Jocassee, and Lake Keowee.

John M., from 26-Jun-2022
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