Charleston Missouri Hotels & Motels

Find the perfect hotel in Charleston using our hotel guide provided below. Find discounted hotel accommodations in or close to Charleston, MO for your upcoming individual or group travel. Discover the most popular Charleston, Missouri hotel and motel rooms. Browse the Charleston area hotels to find the perfect lodging! Please use the provided map of the Charleston hotels. Coordinating a group? Get Charleston Group Hotel Rates

Charleston Hotels/Accommodations

Super 8 by Wyndham Charleston/Sikeston East MO - Charleston
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
310 South Story, Charleston, MO 63834 +1-888-389-4121
  • Two-star Highway hotel
  • Complimentary breakfast is offered
More Photos
From£32
Average 3.5 /5 Latest Reviews Call BookMore Details
Quality Inn Charleston - Sikeston - Charleston
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
102 Drake St., Charleston, MO 63834 +1-888-675-2083
  • 2 star Highway hotel
  • Free breakfast
More Photos
From£45
Average 3.0 /5 Hotel Reviews Call BookMore Details
Motel 6 Sikeston Mo - SIKESTON
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
110 South Interstate Dr., SIKESTON, MO 63801 +1-800-716-8490 ~11.02 miles west of Charleston
  • Low Cost property
More Photos
From£46
Average 3.0 /5 Read Reviews Call BookMore Details
Best Western Plus Sikeston
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
120 South Interstate Dr., Sikeston, MO 63801 +1-800-805-5223 ~11.05 miles west of Charleston
  • Two star Highway hotel
  • Hotel has a green policy Read more
More Photos
From£33
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Days Inn and Suites by Wyndham Sikeston
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
220 South Interstate Dr., Sikeston, MO 63801 +1-888-965-1860 ~11.09 miles west of Charleston
  • 2 star hotel
  • Check-in time: 03:00 PM
More Photos
From£46
Average 3.0 /5 Guest Reviews Call BookMore Details
Quality Inn Cairo I-57 - Cairo
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
13201 Kessler Rd., Cairo, IL 62914 +1-888-788-5576 ~11.20 miles northeast of Charleston
  • Midscale Highway property
  • 2 floors in hotel
More Photos
From£46
Poor 2.0 /5 Recent Reviews Call BookMore Details
Super 8 by Wyndham Sikeston/Miner Area : 2609 East Malone
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
2609 East Malone, Sikeston, MO 63801 +1-888-897-9207 ~11.36 miles west of Charleston
  • Two star Convention Center hotel
  • Free comp. breakfast
More Photos
From£46
Average 3.0 /5 Reviews Call BookMore Details
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) : 100 Matthews Lane
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
100 Matthews Lane, Sikeston, MO 63801 +1-888-311-4278 ~11.37 miles west of Charleston
  • 3-star Highway property
  • Free comp. breakfast
More Photos
From£61
Very good 4.0 /5 Reviews Call BookMore Details
Comfort Inn - Sikeston
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
109 Matthews Lane, Sikeston, MO 63801 +1-888-469-4795 ~11.40 miles west of Charleston
  • 3-star Highway hotel
  • Check in time: 11:00
More Photos
From£65
Average 3.0 /5 Read Reviews Call BookMore Details
Drury Inn & Suites Sikeston
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
2608 East Malone Ave., Sikeston, MO 63801 +1-888-734-9421 ~11.45 miles west of Charleston
  • Midscale Highway property
  • Fitness / Gym is on-site
More Photos
From£80
Very good 4.5 /5 Read Reviews Call BookMore Details
Pear Tree Inn Sikeston in Sikeston
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
2602 East Malone, Sikeston, MO 63801 +1-888-841-5292 ~11.45 miles west of Charleston
  • Three Star Suburban hotel
  • Hotel has an eco-friendly policy See more
More Photos
From£61
Average 3.0 /5 Hotel Reviews Call BookMore Details
Hampton Inn Sikeston - Sikeston
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
1240 Commerce Dr., Sikeston, MO 63801 +1-888-455-5160 ~14.31 miles west of Charleston
  • Affordable Rural property
  • Fitness / Gym is on-site
More Photos
From£61
Average 3.0 /5 Hotel Reviews Call BookMore Details
Holiday Inn Express & Suites Sikeston An Ihg Hotel - Sikeston
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
115 Hospitality Dr., Sikeston, MO 63801 +1-888-965-8297 ~14.33 miles west of Charleston
  • Midscale Rural hotel
  • Fitness / Gym is on-site
More Photos
From£61
Average 3.0 /5 Read Reviews Call BookMore Details
Americas Best Value Inn Ullin Mounds
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
128 Cheekwood Lane, Ullin, IL 62992 +1-888-906-6358 ~25.98 miles north of Charleston
  • Economical hotel
  • Check in time: 15:00
More Photos
From£46
Average 3.0 /5 Hotel Reviews Call BookMore Details
Courtyard by Marriott Cape Girardeau Downtown - Cape Girardeau
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
400 Broadway St., Cape Girardeau, MO 63701 +1-888-749-6785 ~28.56 miles north of Charleston
  • Mid-scale Downtown property
  • 78 rooms in property
More Photos
From£61
Very good 4.0 /5 Review Score Call BookMore Details
Candlewood Suites Cape Girardeau by IHG in Cape Girardeau
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
485 South Mount Auburn Rd., Cape Girardeau, MO 65703 +1-888-878-9982 ~28.61 miles northwest of Charleston
  • Low Cost Highway hotel
  • 85 suites in hotel
More Photos
From£53
Very good 4.0 /5 Read Reviews Call BookMore Details
Hampton Inn Cape Girardeau I 55 East - Cape Girardeau
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
207 South Mount Auburn Rd., Cape Girardeau, MO 63703 +1-888-389-4485 ~29.33 miles northwest of Charleston
  • 3-star Highway hotel
  • Free complimentary breakfast
More Photos
From£61
Excellent 5.0 /5 Hotel Reviews Call BookMore Details
Victorian Inn & Suites - Cape Girardeau
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
3256 William St., Cape Girardeau, MO 63703 +1-888-389-4121 ~29.40 miles northwest of Charleston
  • 3 star Golf Course property
  • Check-in: 3:00 pm
More Photos
From£61
Average 3.0 /5 Read Reviews Call BookMore Details
Auburn Place Hotel & Suites : 3265 Williams St.
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
3265 Williams St., Cape Girardeau, MO 63702 +1-888-675-2083 ~29.41 miles northwest of Charleston
  • Mid-scale Highway hotel
  • Check in time: 0300 pm
More Photos
From£44
Very good 4.5 /5 Guest Reviews Call BookMore Details
Holiday Inn Express & Suites Cape Girardeau I 55 - Cape Girardeau
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
3253 William St., Cape Girardeau, MO 63701 +1-800-716-8490 ~29.43 miles northwest of Charleston
  • Mid-scale property
  • Gym is available on property
More Photos
From£61
Very good 4.5 /5 Review Score Call BookMore Details
Fairfield Inn & Suites Cape Girardeau - Cape Girardeay
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
433 Cape West Crossing, Cape Girardeay, MO 63703 +1-800-805-5223 ~29.46 miles northwest of Charleston
  • 3-star hotel
  • Hotel has 22 suites
More Photos
From£61
Average 3.0 /5 Latest Reviews Call BookMore Details
Pear Tree Inn Cape Girardeau West : 103 Cape West Pkwy.
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
103 Cape West Pkwy., Cape Girardeau, MO 63701 +1-888-965-1860 ~29.49 miles northwest of Charleston
  • Low-priced hotel
  • Hotel has an eco-friendly policy See more
More Photos
From£45
Average 3.0 /5 Read Reviews Call BookMore Details
Pear Tree Inn Cape Girardeau Medical Center in Cape Girardeau
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
3248 William St., Cape Girardeau, MO 63701 +1-888-788-5576 ~29.50 miles northwest of Charleston
  • Low Cost Highway hotel
  • 78 rooms in property
More Photos
From£50
Very good 4.0 /5 Latest Reviews Call BookMore Details
Drury Suites Cape Girardeau - Cape Girardeau
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
3303 Campster Dr., Cape Girardeau, MO 63701 +1-888-897-9207 ~29.60 miles northwest of Charleston
  • Three Star Highway property
  • Hotel has an eco-friendly policy See policy
More Photos
From£65
Very good 4.5 /5 Guest Reviews Call BookMore Details
Drury Plaza Hotel & Conference Center Cape Girardeau
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
3351 Percy Dr., Cape Girardeau, MO 63701 +1-888-311-4278 ~29.76 miles northwest of Charleston
  • Affordable hotel
  • 8 floors in property
More Photos
From£45
Average 3.0 /5 Recent Reviews Call BookMore Details
Drury Lodge
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
104 South Vantage Dr., Cape Girardeau, MO 63701 +1-888-469-4795 ~29.77 miles northwest of Charleston
  • 3-star Highway property
  • Fitness center on property
More Photos
From£61
Average 3.0 /5 Recent Reviews Call BookMore Details
Travel Inn - Marston
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
301 Route Ad, Marston, MO 63866 +1-888-734-9421 ~31.28 miles southwest of Charleston
  • Economy Highway hotel
  • Hotel has 60 rooms
More Photos
From£30
Poor 2.5 /5 Read Reviews Call BookMore Details
Travel Inn : 301 State Highway Ad
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
301 State Highway Ad, Martson, MO 63866 +1-888-841-5292 ~31.46 miles southwest of Charleston
  • Low priced property
More Photos
From£46
Poor 2.5 /5 Latest Reviews Call BookMore Details
Red Roof Inn Marston
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
501 South Outer Rd., Marston, MO 63866 +1-888-455-5160 ~31.61 miles southwest of Charleston
  • Low priced property
  • 2 floors in hotel
More Photos
From£46
Average 3.0 /5 Latest Reviews Call BookMore Details
Quality Inn
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
2011 North Kingshighway St., Cape Girardeau, MO 63701 Website +1-888-965-8297 ~31.73 miles northwest of Charleston
  • Economical property
  • Check-in time: 3:00 PM
More Photos
From£46
Very good 4.0 /5 Hotel Reviews Call BookMore Details
TRU by Hilton Cape Girardeau : 2520 Veterans Memorial Dr.
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
2520 Veterans Memorial Dr., Cape Girardeau, MO 63701 +1-888-906-6358 ~32.92 miles northwest of Charleston
  • 3-star Highway hotel
  • Fitness center on property
More Photos
From£61
Average 3.0 /5 Review Score Call BookMore Details
La Quinta Inn & Suites by Wyndham Jackson / Cape Girardeau
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
3003 South Old Orchard Rd., Jackson, MO 63755 +1-888-749-6785 ~33.46 miles northwest of Charleston
  • 3 star Highway property
  • Check in: 03:00
More Photos
From£65
Very good 4.0 /5 Review Score Call BookMore Details
Comfort Suites Jackson-Cape Girardeau in Jackson
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
2904 Old Orchard Rd., Jackson, MO 63755 Website +1-888-878-9982 ~33.57 miles northwest of Charleston
  • 3 star Highway property
  • Check in: 3.00 pm
More Photos
From£50
Average 3.0 /5 Recent Reviews Call BookMore Details
Comfort Suites : 2904 Old Orchard Rd.
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
2904 Old Orchard Rd., Jackson, 63755 United States +1-888-389-4485 ~33.57 miles northwest of Charleston
  • High-end Highway property
  • Hotel has 64 rooms
More Photos
From£96
Average 3.0 /5 Latest Reviews Call BookMore Details
Residence Inn by Marriott Paducah
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
3900 Coleman Crossing Circle, Paducah, KY 42001 +1-888-389-4121 ~34.97 miles east of Charleston
  • Affordable Suburban property
  • Free breakfast
More Photos
From£68
Very good 4.0 /5 Read Reviews Call BookMore Details
Pear Tree Inn Paducah
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
5006 Hinkleville Rd., Paducah, KY 42001 +1-888-675-2083 ~35.47 miles east of Charleston
  • Cheap Suburban property
  • Hotel has an eco-friendly policy Read more
More Photos
From£42
Very good 4.0 /5 Review Score Call BookMore Details
Econo Lodge Dexter - Dexter
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
913 Outer Rd., Dexter, MO 63841 +1-800-716-8490 ~36.12 miles west of Charleston
  • Low-priced hotel
  • 38 rooms in hotel
More Photos
From£46
Average 3.0 /5 Read Reviews Call BookMore Details
Harrah's Metropolis Hotel & Casino - Metropolis
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
100 East Front St., Metropolis, IL 62960 +1-800-805-5223 ~36.52 miles east of Charleston
  • High end hotel
  • Hotel has 252 rooms
More Photos
From£123
Very good 4.0 /5 Read Reviews Call BookMore Details
Baymont by Wyndham Metropolis in Metropolis
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
203 East Front St., Metropolis, IL 62960 +1-888-965-1860 ~36.55 miles east of Charleston
  • 2-star Riverfront property
  • 117 sleeping rooms in hotel
More Photos
From£34
Average 3.0 /5 Recent Reviews Call BookMore Details
Sleep Inn & Mainstay Suites
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
1111 Blue Heron Lane, Union City, TN 38261 +1-888-788-5576 ~36.64 miles southeast of Charleston
  • Two-star Rural property
  • 40 sleeping rooms in hotel
More Photos
From£46
Average 3.0 /5 Recent Reviews Call BookMore Details
Travelodge by Wyndham Dexter - Dexter
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
1608 West Business U.s. 60, Dexter, MO 63841 +1-888-897-9207 ~36.87 miles west of Charleston
  • 3 star hotel
More Photos
From£51
Very good 4.0 /5 Guest Reviews Call BookMore Details
 Econo Lodge Paducah West I-24
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
5120 Hinkleville Rd., Paducah, KY 42001 +1-888-311-4278 ~37.23 miles east of Charleston
  • Cheap Airport hotel
  • 75 sleeping rooms in hotel
More Photos
From£46
Average 3.0 /5 Guest Reviews Call BookMore Details
Drury Suites Paducah
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
2930 James Sanders Blvd., Paducah, KY 42001 +1-888-469-4795 ~37.34 miles east of Charleston
  • Mid-scale Suburban property
  • Access to gym on-site
More Photos
From£76
Very good 4.0 /5 Guest Reviews Call BookMore Details
Quality Suites Paducah I-24
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
2880 James Sanders Blvd., Paducah, KY 42001 Website +1-888-734-9421 ~37.41 miles east of Charleston
  • Cheap Highway hotel
  • Free comp. breakfast
More Photos
From£46
Average 3.0 /5 Recent Reviews Call BookMore Details
Sleep Inn Union City
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
1111b Blue Heron Lane, Union City, TN 38261 +1-888-841-5292 ~37.44 miles southeast of Charleston
  • Cheap Rural property
  • 40 rooms in property
More Photos
From£60
Very good 4.0 /5 Guest Reviews Call BookMore Details
Comfort Inn & Suites near Six Flags in Lithia Springs
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
960 West Pointe Court, Lithia Springs, GA 30122 Website +1-888-455-5160 ~37.46 miles east of Charleston
  • Mid-scale Downtown property
  • Free breakfast available
More Photos
From£54
Very good 4.0 /5 Guest Reviews Call BookMore Details
Country Inn & Suites by Radisson, Paducah, KY
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
145 Mcbride Lane, Paducah, KY 42001 +1-888-965-8297 ~37.46 miles east of Charleston
  • Three Star Highway hotel
  • 60 rooms in hotel
More Photos
From£37
Very good 4.0 /5 Recent Reviews Call BookMore Details
Baymont by Wyndham Paducah
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
5300 Old Cairo Rd., Paducah, KY 42001 +1-888-906-6358 ~37.50 miles east of Charleston
  • Mid-scale property
  • 74 rooms in hotel
More Photos
From£30
Poor 2.0 /5 Reviews Call BookMore Details
Hotel 7 Inn
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
5001 Hinkleville Rd., Paducah, KY 42001 +1-888-749-6785 ~37.51 miles east of Charleston
  • 2 star hotel
More Photos
From£46
Average 3.0 /5 Read Reviews Call BookMore Details
Econo Lodge in Metropolis
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
1415 East 5th St., Metropolis, IL 62960 +1-888-878-9982 ~37.60 miles east of Charleston
  • Low-priced property
More Photos
From£46
Terrible 1.0 /5 Recent Reviews Call BookMore Details

Next: See My Charleston Hotels with Pricing

Recent traveler reviews of Charleston, MO

Below are reviews of the city of Charleston, MO from an actual visitor's perspective.

"Easily Accessible"
Score 5.0 / 5

Easily accessible.

Mamon T., from 07-Dec-2023
Back to Top