Desoto Missouri Accommodations

Find hotels in Desoto using the list and search tools below. Search for the cheapest discounted hotel and motel rates in or near Desoto, MO for your corporate or personal leisure travel. We show the best Desoto Missouri hotel rooms. Review the Desoto hotel list below to find the perfect lodging. We also have a map of the Desoto hotels.

Desoto Hotels & Accommodations

Holiday Inn Club Vac Timber Creek : 4800 Us Highway 67
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
4800 Us Highway 67, Desoto, MO 63020 +1-888-389-4121
  • Midscale property
  • 3 floors in property
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From$90
Very Good 4.5 /5 Recent Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS, an I : 1802 Gamel Cemetery Rd.
+1-888-675-2083

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New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
1802 Gamel Cemetery Rd., Festus, MO 63028 +1-888-675-2083 ~9.29 miles northeast of Desoto
  • Inexpensive Highway hotel
  • Hotel has 86 rooms
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From$90
Very Good 4.0 /5 Review Score Call BookMore Details
Comfort Inn Festus - St Louis South : 1303 Veterans Blvd.
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
1303 Veterans Blvd., Festus, MO 63028 Website +1-800-716-8490 ~9.49 miles northeast of Desoto
  • 3-star Suburban property
  • Free comp. breakfast
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From$45
Very Good 4.0 /5 Reviews Call BookMore Details
Quality Inn Festus
+1-800-805-5223

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New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
1200 West Gannon Dr., Festus, MO 63028 Website +1-800-805-5223 ~9.52 miles northeast of Desoto
  • 3 star Suburban hotel
  • 7 conference rooms in property
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From$72
Average 3.0 /5 Recent Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Festus - St. Louis South in Festus
+1-888-965-1860

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New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
1001 Veterans Blvd., Festus, MO 63028 +1-888-965-1860 ~9.71 miles northeast of Desoto
  • Three Star Suburban property
  • Free comp. breakfast
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From$80
Average 3.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Pevely
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
1711 Highway Z, Pevely, MO 63070 +1-888-788-5576 ~13.04 miles northeast of Desoto
  • Low-priced hotel
  • Check in time: 11:00 AM
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From$35
Very Good 4.0 /5 Read Reviews Call BookMore Details
Super 8 by Wyndham Bonne Terre : 8 Northwood Dr.
+1-888-897-9207

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New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
8 Northwood Dr., Bonne Terre, MO 63628 +1-888-897-9207 ~14.95 miles south of Desoto
  • Low Cost hotel
  • Check in: 11:00 AM
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From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Motel 6 Bonne Terre Mo
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
1017 Highway K, Bonne Terre, MO 63628 +1-888-311-4278 ~15.14 miles south of Desoto
  • Cheap hotel
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From$60
Average 3.0 /5 Review Score Call BookMore Details
Super 8 by Wyndham Potosi - Potosi
+1-888-469-4795

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New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
820 East High St., Potosi, MO 63664 +1-888-469-4795 ~18.93 miles southwest of Desoto
  • Inexpensive Highway hotel
  • 2 floors in hotel
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From$49
Average 3.0 /5 Reviews Call BookMore Details
Quality Inn & Suites : 3610 West Outer Rd.
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
3610 West Outer Rd., Arnold, MO 63010 Website +1-888-734-9421 ~20.99 miles northeast of Desoto
  • Two star Suburban property
  • Has environment-friendly policy Read more
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From$60
Average 3.0 /5 Latest Reviews Call BookMore Details
Woodspring Suites St. Louis Arnold in Arnold
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
888 Arnold Commons Dr., Arnold, MO 63010 +1-888-841-5292 ~22.48 miles northeast of Desoto
  • 2-star Highway property
  • Check-in: 3 p.m.
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From$32
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Drury Inn & Suites St. Louis Arnold : 3800 State Rt 141
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
3800 State Rt 141, Arnold, MO 63010 +1-888-455-5160 ~22.60 miles northeast of Desoto
  • Mid-scale Suburban property
  • 155 sleeping rooms in hotel
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From$123
Excellent 5.0 /5 Reviews Call BookMore Details
Pear Tree Inn St. Louis Arnold
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
1201 Drury Lane, Arnold, MO 63010 +1-888-965-8297 ~23.18 miles northeast of Desoto
  • Three Star Suburban hotel
  • Hotel has an eco-friendly policy See more
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From$80
Very Good 4.0 /5 Reviews Call BookMore Details
Crown Pointe Lodge, BW Signature Collection
+1-888-906-6358

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New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
4245 Hunt Rd., Farmington, MO 63640 +1-888-906-6358 ~23.30 miles south of Desoto
  • Three Star Golf Course hotel
  • Hotel has 3 floors
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From$65
Very Good 4.0 /5 Read Reviews Call BookMore Details
Best Western St. Louis Inn
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
6224 Heimos Industrial Park Dr., Saint Louis, MO 63129 +1-888-749-6785 ~24.45 miles northeast of Desoto
  • Two-star Suburban property
  • 3 floors in hotel
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From$41
Average 3.0 /5 Guest Reviews Call BookMore Details
Hampton Inn Farmington : 850 Valley Creek Dr.
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
850 Valley Creek Dr., Farmington, MO 63640 +1-888-878-9982 ~24.74 miles south of Desoto
  • Midscale Highway property
  • Hotel has 6 meeting rooms
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From$80
Average 3.0 /5 Reviews Call BookMore Details
Super 8 by Wyndham Farmington : 930 Valley Creek Dr.
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
930 Valley Creek Dr., Farmington, MO 63640 +1-888-389-4485 ~24.81 miles south of Desoto
  • Cheap hotel
  • Check-in: 3:00 pm
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From$49
Average 3.0 /5 Read Reviews Call BookMore Details
Holiday Inn Express & Suites Farmington, an IHG Hotel
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
820 Market St., Farmington, MO 63640 +1-888-389-4121 ~24.84 miles south of Desoto
  • 3 star Rural hotel
  • Check-in: 3:00pm
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From$99
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Fairfield by Marriott : 1680 Fenton Business Park Court
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
1680 Fenton Business Park Court, Fenton, MO 63026 +1-888-675-2083 ~25.52 miles north of Desoto
  • Three Star Suburban hotel
  • Hotel has 102 rooms
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From$80
Average 3.0 /5 Review Score Call BookMore Details
Quality Inn Farmington - Farmington
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
1400 West Liberty St., Farmington, MO 63640 +1-800-716-8490 ~25.67 miles south of Desoto
  • Midscale Rural property
  • 48 rooms in property
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From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
America's Best Inn Eureka : 1725 West 5th St.
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
1725 West 5th St., Eureka, MO 63025 +1-800-805-5223 ~25.91 miles north of Desoto
  • Low Cost Highway hotel
  • Check-in time: 11.00am
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From$60
Poor 2.0 /5 Guest Reviews Call BookMore Details
Super 8 by Wyndham Eureka/Six Flags Nearby in Eureka
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
1733 West 5th St., Eureka, MO 63025 +1-888-965-1860 ~25.97 miles north of Desoto
  • Low priced Highway property
  • Free complimentary breakfast
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From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Baymont Inn and Suites by Wyndham Farmington, MO - Farmington
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
1625 West Columbia St., Farmington, MO 63640 +1-888-788-5576 ~26.01 miles south of Desoto
  • Mid-scale Highway hotel
  • Hotel has 94 rooms
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From$80
Average 3.0 /5 Read Reviews Call BookMore Details
Fairfield Inn N Ste St. Louis South in St Louis
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
4318 Butler Hill Rd., St Louis, MO 63128 +1-888-897-9207 ~26.12 miles northeast of Desoto
  • Mid-scale hotel
  • Check in: 15:00
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From$90
Average 3.0 /5 Latest Reviews Call BookMore Details
Holiday Inn Express & Suites St. Louis South - I-55, an IHG Hotel : 4250 Midamerica Ln
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
4250 Midamerica Ln, St. Louis, MO 63129 +1-888-311-4278 ~26.15 miles northeast of Desoto
  • Affordable Suburban hotel
  • Check in time: 3p
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From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
Quality Inn Near Six Flags St. Louis
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
1400 West Osage St., Pacific, MO 63069 +1-888-469-4795 ~26.20 miles northwest of Desoto
  • Mid-scale Rural property
  • Free complimentary breakfast
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From$80
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Hampton Inn & Suites St. Louis/South I-55
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
4200 Midamerica Ln, St. Louis, MO 63129 +1-888-734-9421 ~26.21 miles northeast of Desoto
  • Mid-scale Suburban hotel
  • Free comp. breakfast
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From$80
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Comfort Inn Near Six Flags St. Louis
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
1320 Thornton St., Pacific, MO 63069 Website +1-888-841-5292 ~26.31 miles northwest of Desoto
  • Three Star Highway property
  • Hotel has 2 suites
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From$88
Average 3.0 /5 Review Score Call BookMore Details
Holiday Inn St. Louis West Six Flags, an IHG Hotel
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
4901 Six Flags Rd., Eureka, MO 63025 +1-888-455-5160 ~26.44 miles north of Desoto
  • Affordable Suburban hotel
  • 4 conference rooms in property
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From$129
Average 3.0 /5 Hotel Reviews Call BookMore Details
Super 8 by Wyndham Waterloo : 112 Warren Dr.
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
112 Warren Dr., Waterloo, IL 62298 +1-888-965-8297 ~26.69 miles northeast of Desoto
  • Economy Rural property
  • Check in: 3:00 PM
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From$60
Average 3.5 /5 Hotel Reviews Call BookMore Details
Super 8 by Wyndham St. Clair MO
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
1010 South Outer Rd., Saint Clair, MO 63077 +1-888-906-6358 ~27.54 miles northwest of Desoto
  • 2-star Highway hotel
  • Hotel has 3 floors
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From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Pinemark Inn & Suites
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
866 South Outer Rd., St. Clair, MO 63077 +1-888-749-6785 ~27.61 miles northwest of Desoto
  • 2 star Highway property
  • 3 suites in hotel
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From$61
Very Good 4.0 /5 Read Reviews Call BookMore Details
Hampton Inn St. Louis Southwest
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
9 Lambert Drury Dr., St. Louis, MO 63088 +1-888-878-9982 ~27.69 miles north of Desoto
  • 3-star Suburban property
  • 4 floors in property
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From$75
Very Good 4.5 /5 Guest Reviews Call BookMore Details
Drury Inn & Suites St. Louis Southwest in St. Louis
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
5 Lambert Drury Place (I 44 & 141), St. Louis, MO 63088 +1-888-389-4485 ~27.70 miles north of Desoto
  • Midscale Suburban property
  • 7 floors in property
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From$84
Very Good 4.5 /5 Recent Reviews Call BookMore Details
Hampton Inn St. Louis Columbia : 165 Admiral Trost Dr.
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
165 Admiral Trost Dr., Columbia, IL 62236 +1-888-389-4121 ~27.77 miles northeast of Desoto
  • Mid-scale Suburban property
  • Check in time: 3:00 PM
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From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Holiday Inn Express St. Louis West Fenton in Fenton
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
1848 Bowles Ave., Fenton, MO 63026 +1-888-675-2083 ~28.01 miles north of Desoto
  • Three Star Suburban hotel
  • Hotel has an eco-friendly policy Learn more
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From$80
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Motel 6 Fenton Mo : 1860 Bowles Ave.
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
1860 Bowles Ave., Fenton, MO 63026 +1-800-716-8490 ~28.03 miles north of Desoto
  • Economy property
  • 58 sleeping rooms in hotel
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From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Wingate by Wyndham St. Louis / Fenton Route 66
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
1100 South Highway Dr., Fenton, MO 63026 +1-800-805-5223 ~28.15 miles north of Desoto
  • Mid-scale Suburban hotel
  • Check in: 3:00 PM
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From$80
Average 3.0 /5 Read Reviews Call BookMore Details
Drury Inn & Suites St. Louis Fenton : 1088 South Highway Dr.
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
1088 South Highway Dr., Fenton, MO 63026 +1-888-965-1860 ~28.26 miles north of Desoto
  • Mid-scale Suburban hotel
  • Hotel has 11 suites
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From$94
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Extended Stay America Suites St. Louis Fenton in Fenton
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
1662 Fenton Business Park Court, Fenton, MO 63026 +1-888-788-5576 ~28.29 miles north of Desoto
  • 3 star Suburban property
  • Free comp. breakfast
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From$80
Average 3.0 /5 Read Reviews Call BookMore Details
Americas Best Value Inn St. Louis South - St. Louis
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
6602 South Lindbergh Blvd., St. Louis, MO 63123 +1-888-897-9207 ~28.30 miles northeast of Desoto
  • 2-star Suburban hotel
  • Free breakfast available
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From$49
Poor 2.0 /5 Review Score Call BookMore Details
Super 8 by Wyndham Fenton/St. Louis Area - Fenton
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
650 South Highway Dr., Fenton, MO 63026 +1-888-311-4278 ~28.38 miles north of Desoto
  • Economy property
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From$60
Poor 2.0 /5 Hotel Reviews Call BookMore Details
Aviator Hotel & Suites South I 55 Best Western Signature Collecti in St Louis
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
6921 South Lindbergh Blvd., St Louis, MO 63125 +1-888-469-4795 ~28.39 miles northeast of Desoto
  • Affordable Suburban property
  • 149 rooms in property
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From$80
Average 3.0 /5 Guest Reviews Call BookMore Details
Microtel Inn & Suites by Wyndham Sainte Genevieve - Sainte Genevieve
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
21958 Highway 32, Sainte Genevieve, MO 63670 +1-888-734-9421 ~29.61 miles east of Desoto
  • Cheap Highway hotel
  • Check-in time: 3:00 pm
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From$75
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Days Inn by Wyndham St. Louis Lindbergh Boulevard - St Louis
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
3660 South Lindbergh Blvd., St Louis, MO 63127 +1-888-841-5292 ~29.65 miles north of Desoto
  • 3-star Suburban hotel
  • Free breakfast available
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From$69
Average 3.0 /5 Review Score Call BookMore Details
Holiday Inn St. Louis Sw Route 66 An Ihg Hotel - St. Louis
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
10709 Watson Rd., St. Louis, MO 63127 +1-888-455-5160 ~29.82 miles north of Desoto
  • Affordable Suburban hotel
  • 12 suites in property
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From$79
Average 3.0 /5 Latest Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham - Saint Louis
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
1580 South Kirkwood Rd., Saint Louis, MO 63127 +1-888-965-8297 ~29.89 miles north of Desoto
  • Midscale Suburban property
  • Access to gym on-site
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From$100
Average 3.0 /5 Guest Reviews Call BookMore Details
Best Western St. Louis-Kirkwood Route 66 - Saint Louis
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
1200 South Kirkwood Rd., Saint Louis, MO 63122 +1-888-906-6358 ~30.33 miles north of Desoto
  • 3 star Suburban hotel
  • Complimentary breakfast is offered
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From$70
Very Good 4.0 /5 Reviews Call BookMore Details
The Wildwood Hotel
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
2801 Fountain Place, Wildwood, MO 63040 +1-888-749-6785 ~30.80 miles north of Desoto
  • Four star Suburban hotel
  • Hotel has 5 floors
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From$100
Very Good 4.0 /5 Read Reviews Call BookMore Details
Super 8 by Wyndham Union
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
1015 East Main St., Union, MO 63084 +1-888-878-9982 ~31.93 miles northwest of Desoto
  • 2-star Rural property
  • Comp. Breakfast
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From$67
Average 3.0 /5 Latest Reviews Call BookMore Details

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