Accommodations close to Mayo Clinic are shown in the list below sorted in the order of their distance (closest first). Browse our hotels to find accommodations near Mayo Clinic (Mayo Clinic) for your leisure or corporate trips. Mayo Clinic is located at 4500 San Pablo Rd S. We show the best lodging close to Mayo Clinic so you can review the available Mayo Clinic lodging below and securely book your ideal hotel.
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Book online or call +1-800-219-2797
Residence Inn Jacksonville East, Hampton Inn Jacksonville Beach and Courtyard by Marriott Jacksonville Beach Oceanfront are the best rated hotels based on customer reviews in the last 365 days.
Enso, Ponte Vedra Inn & Club and The Lodge and Club at Ponte Vedra Beach are the top 3 luxury hotels near Mayo Clinic.
Courtyard by Marriott Jacksonville at Mayo Clinic Campus, The Inn at Mayo Clinic, and Residence Inn Jacksonville East are the properties closest to Mayo Clinic.
The Inn at Mayo Clinic, Margaritaville Jacksonville and Ponte Vedra Inn & Club are the best rated independent hotels (not part of a big brand).
Residence Inn Jacksonville East, Courtyard by Marriott Jacksonville Beach Oceanfront and Courtyard by Marriott Oceanfront Jacksonville Beach are the best rated Marriott/Starwood branded hotels (based on customer reviews score).
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area, an IH, Holiday Inn Express Jacksonville Beach, an IHG Hotel and Holiday Inn Express & Suites Jacksonville Town Center are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).