Sikeston Missouri Accommodations

Find the perfect hotel in Sikeston using our hotel guide provided below. Search for cheap and discounted hotel and motel rates in or near Sikeston, MO for your business or personal leisure travel. We list the best Sikeston Missouri hotel rooms. Review the Sikeston hotel list below to find the perfect lodging. We also have a map of the Sikeston hotels. Coordinating a group? Get Sikeston Group Hotel Discounts

"Welcome to Sikeston, Missouri: The Best of Missouri’s Bountiful Bootheel"

Sikeston is a city located in both southern Scott County and northern New Madrid County in the state of Missouri. The town is situated north of Missouri's 'Bountiful Bootheel,' although many locals consider Sikeston a part of it, even calling it 'The Best of Missouri's Bountiful Bootheel'. Once a region of cypress swamps and forested prairies, Sikeston is now lined with businesses and older historic architecture. More from this guide...

Sikeston Hotels & Accommodations

Hampton Inn Sikeston
+1-888-389-4121
1240 Commerce Dr., Sikeston, MO 63801 +1-888-389-4121
  • 3 star Rural hotel
  • 4 floors in hotel
From$80
Average 3.0 /5 Reviews Call BookMore Details
Holiday Inn Express & Suites Sikeston An Ihg Hotel - Sikeston
+1-888-675-2083
115 Hospitality Dr., Sikeston, MO 63801 +1-888-675-2083
  • Three Star Rural property
  • Hotel has 73 rooms
From$80
Average 3.0 /5 Guest Reviews Call BookMore Details
Pear Tree Inn Sikeston
+1-800-716-8490
2602 East Malone, Sikeston, MO 63801 +1-800-716-8490
  • Three Star Suburban hotel
  • Hotel has an eco-friendly policy See more
From$80
Average 3.0 /5 Reviews Call BookMore Details
Drury Inn & Suites Sikeston - Sikeston
+1-800-805-5223
2608 East Malone Ave., Sikeston, MO 63801 +1-800-805-5223
  • Affordable Highway property
  • Hotel has an eco-friendly policy See policy
From$104
Very Good 4.5 /5 Read Reviews Call BookMore Details
Comfort Inn in Sikeston
+1-888-965-1860
109 Matthews Lane, Sikeston, MO 63801 +1-888-965-1860
  • Three Star Highway hotel
  • 64 rooms in property
From$85
Average 3.0 /5 Recent Reviews Call BookMore Details
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) - Sikeston
+1-888-788-5576
100 Matthews Lane, Sikeston, MO 63801 +1-888-788-5576
  • Midscale Highway hotel
  • Free breakfast
From$80
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Super 8 by Wyndham Sikeston/Miner Area : 2609 East Malone
+1-888-897-9207
2609 East Malone, Sikeston, MO 63801 +1-888-897-9207
  • 2 star Convention Center hotel
  • Check in: 01:00
From$60
Average 3.0 /5 Read Reviews Call BookMore Details
Best Western Plus Sikeston - Sikeston
+1-888-311-4278
120 South Interstate Dr., Sikeston, MO 63801 +1-888-311-4278
  • 2 star Highway property
  • Check-in: 03:00
From$43
Very Good 4.0 /5 Read Reviews Call BookMore Details
Days Inn and Suites by Wyndham Sikeston
+1-888-469-4795
220 South Interstate Dr., Sikeston, MO 63801 +1-888-469-4795
  • Inexpensive property
  • Check in: 03:00 PM
From$60
Average 3.0 /5 Read Reviews Call BookMore Details
Motel 6 Sikeston Mo : 110 South Interstate Dr.
+1-888-734-9421
110 South Interstate Dr., SIKESTON, MO 63801 +1-888-734-9421
  • Cheap property
From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Quality Inn Charleston - Sikeston
+1-888-841-5292
102 Drake St., Charleston, MO 63834 +1-888-841-5292 ~12.72 miles east of Sikeston
  • Cheap Highway hotel
  • Gym / Fitness Center Available
From$59
Average 3.0 /5 Read Reviews Call BookMore Details
Super 8 by Wyndham Charleston/Sikeston East MO : 310 South Story
+1-888-455-5160
310 South Story, Charleston, MO 63834 +1-888-455-5160 ~14.40 miles east of Sikeston
  • Economy Highway property
  • Free breakfast available
From$42
Average 3.5 /5 Guest Reviews Call BookMore Details
Econo Lodge Dexter : 913 Outer Rd.
+1-888-965-8297
913 Outer Rd., Dexter, MO 63841 +1-888-965-8297 ~22.31 miles west of Sikeston
  • Low Cost property
  • Check in: 11:00
From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Travelodge by Wyndham Dexter : 1608 West Business U.s. 60
+1-888-906-6358
1608 West Business U.s. 60, Dexter, MO 63841 +1-888-906-6358 ~23.06 miles west of Sikeston
  • 3-star property
From$67
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Quality Inn Cairo I-57
+1-888-749-6785
13201 Kessler Rd., Cairo, IL 62914 +1-888-749-6785 ~23.62 miles east of Sikeston
  • 3-star Highway hotel
  • Check in: 3 pm
Travel Inn : 301 Route Ad
+1-888-878-9982
301 Route Ad, Marston, MO 63866 +1-888-878-9982 ~25.50 miles south of Sikeston
  • Low-priced Highway property
  • Hotel has 60 rooms
Travel Inn
+1-888-389-4485
301 State Highway Ad, Martson, MO 63866 +1-888-389-4485 ~25.66 miles south of Sikeston
  • Cheap property
Red Roof Inn Marston
+1-888-389-4121
501 South Outer Rd., Marston, MO 63866 +1-888-389-4121 ~25.88 miles south of Sikeston
  • Low Cost hotel
  • 63 rooms in hotel
From$60
Average 3.0 /5 Latest Reviews Call BookMore Details
Candlewood Suites Cape Girardeau, an IHG Hotel
+1-888-675-2083
485 South Mount Auburn Rd., Cape Girardeau, MO 65703 +1-888-675-2083 ~27.56 miles north of Sikeston
  • Cheap Highway hotel
  • 85 rooms in property
From$69
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Hampton Inn Cape Girardeau I 55 East in Cape Girardeau
+1-800-716-8490
207 South Mount Auburn Rd., Cape Girardeau, MO 63703 +1-800-716-8490 ~28.24 miles north of Sikeston
  • Mid-scale Highway property
  • Check-in: 15:00
From$80
Excellent 5.0 /5 Guest Reviews Call BookMore Details
Fairfield Inn & Suites Cape Girardeau
+1-800-805-5223
433 Cape West Crossing, Cape Girardeay, MO 63703 +1-800-805-5223 ~28.28 miles north of Sikeston
  • 3-star hotel
From$80
Average 3.0 /5 Latest Reviews Call BookMore Details
Pear Tree Inn Cape Girardeau West
+1-888-965-1860
103 Cape West Pkwy., Cape Girardeau, MO 63701 +1-888-965-1860 ~28.29 miles north of Sikeston
  • Inexpensive hotel
  • Hotel has 81 rooms
From$59
Average 3.0 /5 Read Reviews Call BookMore Details
Holiday Inn Express & Suites Cape Girardeau I 55 : 3253 William St.
+1-888-788-5576
3253 William St., Cape Girardeau, MO 63701 +1-888-788-5576 ~28.33 miles north of Sikeston
  • Midscale property
  • Check in time: 11:00
From$80
Very Good 4.5 /5 Hotel Reviews Call BookMore Details
Victorian Inn & Suites
+1-888-897-9207
3256 William St., Cape Girardeau, MO 63703 +1-888-897-9207 ~28.38 miles north of Sikeston
  • Affordable Golf Course property
  • Check in time: 3:00 pm
From$79
Average 3.0 /5 Recent Reviews Call BookMore Details
Auburn Place Hotel & Suites - Cape Girardeau
+1-888-311-4278
3265 Williams St., Cape Girardeau, MO 63702 +1-888-311-4278 ~28.39 miles north of Sikeston
  • Midscale Highway hotel
  • Hotel has 2 floors
From$58
Very Good 4.5 /5 Read Reviews Call BookMore Details
Drury Suites Cape Girardeau - Cape Girardeau
+1-888-469-4795
3303 Campster Dr., Cape Girardeau, MO 63701 +1-888-469-4795 ~28.41 miles north of Sikeston
  • Midscale Highway hotel
  • Check-in time: 3:00 PM
From$85
Very Good 4.5 /5 Guest Reviews Call BookMore Details
Pear Tree Inn Cape Girardeau Medical Center in Cape Girardeau
+1-888-734-9421
3248 William St., Cape Girardeau, MO 63701 +1-888-734-9421 ~28.43 miles north of Sikeston
  • Cheap Highway hotel
  • Check in time: 3:00 pm
From$66
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Drury Lodge
+1-888-841-5292
104 South Vantage Dr., Cape Girardeau, MO 63701 +1-888-841-5292 ~28.63 miles north of Sikeston
  • Affordable Highway property
  • Comp. Breakfast
From$80
Average 3.0 /5 Latest Reviews Call BookMore Details
Drury Plaza Hotel & Conference Center Cape Girardeau
+1-888-455-5160
3351 Percy Dr., Cape Girardeau, MO 63701 +1-888-455-5160 ~28.65 miles north of Sikeston
  • Midscale hotel
  • 52 suites in property
From$59
Average 3.0 /5 Hotel Reviews Call BookMore Details
Courtyard by Marriott Cape Girardeau Downtown : 400 Broadway St.
+1-888-965-8297
400 Broadway St., Cape Girardeau, MO 63701 +1-888-965-8297 ~28.89 miles north of Sikeston
  • Three Star Downtown property
  • 78 sleeping rooms in hotel
From$80
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Quality Inn - Cape Girardeau
+1-888-906-6358
2011 North Kingshighway St., Cape Girardeau, MO 63701 Website +1-888-906-6358 ~30.77 miles north of Sikeston
  • Two star hotel
  • 49 rooms in property
From$60
Very Good 4.0 /5 Recent Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Jackson / Cape Girardeau
+1-888-749-6785
3003 South Old Orchard Rd., Jackson, MO 63755 +1-888-749-6785 ~31.91 miles north of Sikeston
  • Mid-scale Highway hotel
  • Fitness / Gym is on-site
From$85
Very Good 4.0 /5 Read Reviews Call BookMore Details
Comfort Suites Jackson-Cape Girardeau - Jackson
+1-888-878-9982
2904 Old Orchard Rd., Jackson, MO 63755 Website +1-888-878-9982 ~32.09 miles north of Sikeston
  • 3-star Highway property
  • Free breakfast available
From$65
Average 3.0 /5 Hotel Reviews Call BookMore Details
Comfort Suites
+1-888-389-4485
2904 Old Orchard Rd., Jackson, 63755 United States +1-888-389-4485 ~32.09 miles north of Sikeston
  • Four star Highway property
  • Hotel has 3 floors
From$125
Average 3.0 /5 Reviews Call BookMore Details
Americas Best Value Inn Ullin Mounds : 128 Cheekwood Lane
+1-888-389-4121
128 Cheekwood Lane, Ullin, IL 62992 +1-888-389-4121 ~35.03 miles northeast of Sikeston
  • Inexpensive property
  • Check in time: 15:00
From$60
Average 3.0 /5 Review Score Call BookMore Details
Drury Inn & Suites Jackson Missouri
+1-888-675-2083
225 Drury Lane, Jackson, MO 63755 +1-888-675-2083 ~37.27 miles north of Sikeston
  • 3-star Suburban property
  • 24 suites in property
From$79
Very Good 4.5 /5 Hotel Reviews Call BookMore Details
Sleep Inn & Mainstay Suites : 1111 Blue Heron Lane
+1-800-716-8490
1111 Blue Heron Lane, Union City, TN 38261 +1-800-716-8490 ~42.44 miles southeast of Sikeston
  • Economy Rural property
  • 40 sleeping rooms in hotel
From$60
Average 3.0 /5 Latest Reviews Call BookMore Details
Sleep Inn Union City
+1-800-805-5223
1111b Blue Heron Lane, Union City, TN 38261 +1-800-805-5223 ~43.32 miles southeast of Sikeston
  • Economical Rural hotel
  • Check in time: 3:00 PM
From$78
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Country Hearth Inn & Suites Union City : 2009 West Reelfoot Ave.
+1-888-965-1860
2009 West Reelfoot Ave., Union City, TN 38261 +1-888-965-1860 ~43.40 miles southeast of Sikeston
  • Low-priced Highway hotel
  • Check-in: 3:00 PM
From$71
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Quality Inn Union City Us 51 in Union City
+1-888-788-5576
2201 West Reelfoot Ave., Union City, TN 38261 +1-888-788-5576 ~43.47 miles southeast of Sikeston
  • Affordable Rural hotel
  • Check in: 3:00pm
From$69
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Mainstay Suites
+1-888-897-9207
1111a Blue Heron Lane, Union City, TN 38261 +1-888-897-9207 ~43.51 miles southeast of Sikeston
  • 2 star Rural hotel
  • Hotel has an eco-friendly policy Read more
From$85
Average 3.0 /5 Guest Reviews Call BookMore Details
Holiday Inn Express - Union City
+1-888-311-4278
810 Bream Blvd., Union City, TN 38261 +1-888-311-4278 ~43.51 miles southeast of Sikeston
  • Midscale Rural hotel
  • Check-in time: 3:00PM
From$60
Very Good 4.0 /5 Read Reviews Call BookMore Details
Rosewood Inn - Union City
+1-888-469-4795
1400 Vaden St., Union City, TN 38261 +1-888-469-4795 ~43.55 miles southeast of Sikeston
  • Affordable property
  • 47 rooms in property
Drury Inn & Suites Hayti / Caruthersville in Hayti
+1-888-734-9421
1317 Mo 84, Hayti, MO 63851 +1-888-734-9421 ~43.77 miles south of Sikeston
  • Mid-scale Suburban hotel
  • 97 rooms in property
From$93
Average 3.0 /5 Reviews Call BookMore Details
Hotel 7 Inn Anna : 100 Richview Dr.
+1-888-841-5292
100 Richview Dr., Anna, IL 62906 +1-888-841-5292 ~44.20 miles northeast of Sikeston
  • Low Cost property
From$60
Very Good 4.0 /5 Guest Reviews Call BookMore Details

Next: See My Sikeston Hotels with Pricing

When is the Best Time to Visit Sikeston, MO?

Sikeston is less temperate compared to other tourist destinations worldwide. The best time to visit the city for ideal weather is in April, May, or June, considering that the humidity and temperatures make the season feel moderate. However, May is also among the busiest months for tourism in the city. You will find that February and March are also peak season for tourism.

Tourists are least likely to visit in November because the season is starting to get cold. Prices for flights and hotel rooms are most expensive during the busiest months, but you can get better deals by booking them earlier. You could also visit Sikeston in the less popular months. During these times, you can score more affordable prices and enjoy a more peaceful vacation. Even if the colder weather may not be ideal for most outdoor activities.

Which Hotels in Sikeston, MO Offer the Best Discounts?

If you're an AAA member, Sikeston has a variety of hotel options that offer great discounts! Super 8 by Wyndham Sikeston is known for their accommodating staff and offers a discount for AAA members. The hotel also offers connecting/adjoining rooms which are subject to availability, with daily housekeeping and other conveniences such as desks, microwaves, and hair dryers.

When you stay at Comfort Inn & Suites Sikeston, you have access to recreation activities nearby such as an indoor pool and a fitness center. The hotel also offers wheelchair accessible parking, free self-parking, and a safe-deposit box at the front desk. AAA members can enjoy a discount.

For those who want to stay connected even away from home, take a look at the Quality Inn Charleston I 57 in Drake St. Charleston is known for its high speed wired and wireless internet access, free local calls, and daily USA TODAY newspapers. It also provides great meeting space and fresh coffee and tea in the lobby, available 24 hours every day. A discount is available for AAA members.

Last, but not least, consider staying at the Econo Lodge Dexter along Outer Rd. Dexter not only offers AAA discounts, but is incredibly convenient with its proximity to the airport. The motel also offers designated smoking areas and includes amenities such as 32-inch flat-screen televisions with satellite programming for the entertainment of their guests and free Wi-Fi access.

What are Some of the Best Value Options in Sikeston, MO?

You may want to consider some hotel options which not only meet your needs but throw in a few extra perks with your accommodation to make sure you're getting the best value for your money. Located along East Malone Ave., there's always something for everyone in Drury Inn & Suites because they offer a complimentary breakfast that includes make-your-own Belgian waffles, scrambled eggs, sausage, fresh fruit, oatmeal, biscuits, and gravy. The hotel also provides group discounts. Conveniences include a self-controlled heating/cooling system, an ice maker, and ironing facilities.

Alternatively, Pear Tree Inn Sikeston also offers complimentary breakfast and group discounts. However, the one thing that sets this hotel apart from others is its green eco-friendly policy and commitment to green sustainability through their small efforts such as their shower amenity dispensers that reduce contribution to landfills. Also, their towel program aims to decrease water consumption. They even reduce plastic waste through their recycled key program. Not only does the hotel give you great value, but their policies make it great for the environment, too.

What Is There To Explore in Sikeston, MO?

Of course, a visit isn't only about relaxation, but also an adventure! Sikeston has a list of popular tourist destinations for you to visit.

Restored in 1916, Sikeston Depot & Museum has a historic museum and art gallery featuring local and visiting artists. Its cultural center also displays traveling exhibits from national museums. This spot is popular for romantic dates and for families.

Dine at the best restaurants in Cape Girardeau and experience the excitement of their casino with tables games, slots, video poker, and live entertainment! Isle Casino Cape Girardeau is surely a stop for those looking to have a good time. You can also test your golfing skills at Boot Heel Golf Club, an 18-hole Boot Heel course featuring 6,891 yards of golf. This may be a challenging but fun experience for both you and your loved ones.

Malco Sikeston Cinema and Grill is perfect for a family night out or even a lovely date. It is a newer theater in town that also serves up some really good food. When you are done with your dinner and a movie, take a stroll down the lane and window shop. This area is surrounded by the cutest little shops. This can be an incredibly romantic way to wind down your evening walking hand in hand together; simply chatting while taking in all the unique things to see on this street.

The list goes on for Sikeston, but it's always up to you to decide what is best do with your visit. Whether you're just paying a quick visit or looking into an extended stay, Sikeston will surely have the hotel options to accommodate you, your loved ones, and especially your travel needs.

Recent traveler reviews of Sikeston, MO

Below are reviews of the city of Sikeston, MO from an actual visitor's perspective.

"Lamberts!"
Score 5.0 / 5

Lamberts. Lol

Cindy J., from 02-Nov-2024
"Very Nice City"
Score 5.0 / 5

Looks like a very nice city! If you like the South, come to this area!

Tom K., from 07-Oct-2024
"Lamberts!"
Score 5.0 / 5

Lamberts!

Ricky J., from 24-Sep-2024
"Amenities, shopping and restaurants!"
Score 5.0 / 5

Amenities, shopping and restaurants!

Marjorie B., from 06-Aug-2024
"Lamberts!"
Score 5.0 / 5

Lamberts!

Patrice R., from 04-Aug-2024
"The room was clean, comfortable. The staff was friendly. "
Score 5.0 / 5

The room was clean, comfortable. The staff was friendly. Easy to get around the city very nice area good restaurants with good food

Barbara S., from 08-Jul-2024
"Quick & Easy"
Score 4.0 / 5

Quick check-in process. Location right off the highway.

Geoffrey C., from 06-Jul-2024
"Great selection of places to eat."
Score 5.0 / 5

Great selection of places to eat.

Judith C., from 04-Jul-2024
"Clean!"
Score 4.0 / 5

Clean!

Beverly W., from 28-Jun-2024
"Beautiful Parks by Rodeo Grounds"
Score 4.0 / 5

The parks by the rodeo grounds are beautifully kept up.

Deborah B., from 22-Jun-2024
"Balloon Fest"
Score 5.0 / 5

There was a balloon fest in town when we were there. Very beautiful. Everything was easy to access.

Pam K., from 22-Jun-2024
"Safe Area Near Lambert's Cafe"
Score 5.0 / 5

The area feels safe. Lambert's Cafe has good food.

Jennea A., from 18-Jun-2024
"Close to I-55"
Score 5.0 / 5

Close to Interstate 55.

Joyce H., from 10-Jun-2024
"The room was clean, comfortable. The staff was friendly."
Score 5.0 / 5

The room was clean, comfortable. The staff was friendly. The Mexican restaurant El Napalito was so good, and the staff is excellent. This area is full of good people

Teresa C., from 11-May-2024
"Lamberts!"
Score 5.0 / 5

Lamberts!

Bill R., from 24-Feb-2024
"Good Japanese Restaurant"
Score 5.0 / 5

We ate at Watami Japanese Restaurant. It was a nice restaurant and their food was good.

Heidi W., from 19-Feb-2024
"Lambert's Cafe!"
Score 5.0 / 5

Lambert's has delicious food!

Rita M., from 28-Dec-2023
"Fantastic Food & Fun at Lambert's!"
Score 5.0 / 5

Loved Lambert's Cafe! Fantastic food and fun...melt in your mouth rolls!

Rita M., from 28-Dec-2023
"Lambert's!"
Score 5.0 / 5

Lambert's!

Diana M., from 21-Dec-2023
"Downtown Shopping Area!"
Score 5.0 / 5

Downtown shopping area!

Dan C., from 18-Dec-2023
"Lambert's!"
Score 5.0 / 5

We met with some friends and ate at Lambert's!

Edward D., from 21-Nov-2023
"Excellent Chinese Restaurant!"
Score 4.0 / 5

Chinese restaurant is excellent!

Linda S., from 17-Sep-2023
"So Convenient!"
Score 5.0 / 5

I like how everthing i needed was on one street!

Michael L., from 29-Jun-2023
"Lambert’s was a great asset!"
Score 4.0 / 5

Lambert's was a great asset!

Enoch O., from 28-May-2023
"Very clean, comfortable, staff is very friendly and helpful."
Score 4.0 / 5

Very clean, comfortable, staff is very friendly and helpful. Customer service excellent.

Shelton B., from 12-May-2023
"Good Restaurants!"
Score 4.0 / 5

Good restaurant experiences. God's Country! Very friendly folks everywhere!

Nile M., from 21-Apr-2023
"Beds were comfortable. Bathrooms were clean."
Score 4.0 / 5

Beds were comfortable. Bathrooms were clean. Peaceful, clean and friendly

Kimble A., from 06-Apr-2023
"Plenty of restaurants!"
Score 4.0 / 5

Plenty of restaurants!

Larry P., from 28-Mar-2023
"The rooms were very clean, and the bed was comfortable. "
Score 4.0 / 5

We were there for two nights. Very pleased with the breakfast. Very clean. Nice worker bees!!!

Jewel W., from 17-Mar-2023
"Conveniently Located Hotel"
Score 4.0 / 5

Convenient location with very easy access to I-55.

Diane S., from 01-Feb-2023
"Lamberts Cafe!"
Score 4.0 / 5

Lamberts Cafe!

Brian R., from 26-Jan-2023
"Lamberts Cafe is the Best!!!!"
Score 5.0 / 5

Lamberts Cafe is the best!!!!

Brian R., from 22-Jan-2023
"Grecian Steakhouse was excellent."
Score 4.0 / 5

The clerk at the Pear Tree Inn suggested we try eating at the Grecian Steakhouse and it was excellent.

Susan K., from 31-Oct-2022
"Sikeston Rodeo"
Score 5.0 / 5

Sikeston Rodeo was great!

Joseph H., from 13-Aug-2022
"Clean Room"
Score 5.0 / 5

Lamberts small town feel ... glad it had a walmart.

Bonnie S., from 13-Jun-2022
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