Star Rating
Hotel Name
Price Range (USD) to
Amenities
+ More

Hotels Near South Main - Houston Texas

Accommodations near South Main are provided below in the order of their distance. Explore our hotel guide to find lodging near South Main (in South Main) for your upcoming individual or group travel. We sell the best lodging close to South Main so you can review the discounted South Main lodging below and uncover the perfect hotel. Planning a meeting? Find a South Main group discount

Lodging & Accommodations close to South Main

Bayou City Event Center : 9401 Knight Rd.
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
9401 Knight Rd., Houston, TX 77045 ~0.21 miles east of South Main
~3 minute walk
  • Low priced hotel
More Photos hotel room
From$60
Average 3.0 /5 Review Score Call BookMore Details
Tired of clicking around? Talk to an expert Hotel Planner: (855) 276-7561 or say...
alexa hotel planner skill"Alexa, ask Hotel Planner to make a new reservation near South Main" Get Alexa Skill →
Wyndham Houston near NRG Park/Medical Center
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
8686 Kirby Dr., Houston, TX 77054 ~1.06 miles northwest of South Main
~19 minute walk
  • Affordable Convention Center property
  • Hotel has 8 meeting rooms
More Photos Image of Wyndham Houston near NRG Park/Medical Center
From$75
Average 3.0 /5 Read Reviews Call BookMore Details
Quality Inn & Suites NRG Park - Medical Center - Houston
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
2364 South Loop West, Houston, TX 77054 ~1.08 miles northwest of South Main
~19 minute walk
  • Two-star Highway property
  • Check in time: 3:00 pm
More Photos Photo of Quality Inn & Suites NRG Park - Medical Center
From$60
Average 3.0 /5 Latest Reviews Call BookMore Details
Wingate by Wyndham Near Nrg Park / Medical Center
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
8600 Kirby Dr., Houston, TX 77054 ~1.10 miles northwest of South Main
~19 minute walk
  • Midscale Convention Center hotel
  • Airport shuttle provided
More Photos Image of Wingate by Wyndham Near Nrg Park / Medical Center
From$80
Poor 2.0 /5 Review Score Call BookMore Details
Best Way Inn Houston - Medical Center : 3100 Holmes Rd.
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
3100 Holmes Rd., Houston, TX 77051 ~1.42 miles east of South Main
~25 minute walk
  • Two-star hotel
  • 42 sleeping rooms in hotel
More Photos Image of Best Way Inn Houston - Medical Center
From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
Extended Stay America - Houston - Med Ctr-NRG Park-Fannin in Houston
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
7979 Fannin, Houston, TX 77054 ~1.48 miles north of South Main
~26 minute walk
  • Cheap Convention Center property
  • 153 sleeping rooms in hotel
More Photos Exterior of Extended Stay America - Houston - Med Ctr-NRG Park-Fannin
From$49
Poor 2.5 /5 Reviews Call BookMore Details
Candlewood Suites Houston Medical Center, an IHG Hotel : 10025 South Main St.
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
10025 South Main St., Houston, TX 77025 ~1.55 miles west of South Main
  • Economical Highway hotel
  • Hotel has 80 rooms
More Photos Photo of Candlewood Suites Houston Medical Center, an IHG Hotel
From$54
Average 3.0 /5 Read Reviews Call BookMore Details
Holiday Inn Houston S - Nrg Area - Medical Center, an IHG Hotel : 8111 Kirby Dr.
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
8111 Kirby Dr., Houston, TX 77054 ~1.63 miles north of South Main
  • Three Star Suburban hotel
  • 6 suites in hotel
More Photos Photo of Holiday Inn Houston S - Nrg Area - Medical Center, an IHG Hotel
From$126
Average 3.5 /5 Guest Reviews Call BookMore Details
Rest Up Inn : 10015 South Main St.
+1-888-469-4795

How should we direct your call?

New Reservations: +1-888-469-4795 Group Sales: +1-888-494-8863
10015 South Main St., Houston, TX 77025 ~1.67 miles west of South Main
  • 2-star Convention Center hotel
  • 2 floors in hotel
More Photos Exterior of Rest Up Inn
From$40
Poor 2.0 /5 Read Reviews Call BookMore Details
Extended Stay America Suites Houston Med Ctr NRG Park Kirby
+1-888-734-9421

How should we direct your call?

New Reservations: +1-888-734-9421 Group Sales: +1-888-494-8863
1303 La Concha Ln, Houston, TX 77054 ~1.68 miles north of South Main
  • 2-star Convention Center property
  • Free breakfast available
More Photos Image of Extended Stay America Suites Houston Med Ctr NRG Park Kirby
From$41
Average 3.0 /5 Reviews Call BookMore Details
Holiday Inn Express & Suites Houston S - Medical Ctr Area
+1-888-841-5292

How should we direct your call?

New Reservations: +1-888-841-5292 Group Sales: +1-888-494-8863
9300 South Main St., Houston, TX 77025 ~1.69 miles northwest of South Main
  • Low Cost Downtown property
  • 30 suites in property
More Photos Image of Holiday Inn Express & Suites Houston S - Medical Ctr Area
From$99
Very Good 4.0 /5 Reviews Call BookMore Details
Comfort Suites near Texas Medical Center - NRG Stadium : 1055 Mcnee Rd.
+1-888-455-5160

How should we direct your call?

New Reservations: +1-888-455-5160 Group Sales: +1-888-494-8863
1055 Mcnee Rd., Houston, TX 77054 ~1.73 miles northwest of South Main
  • Affordable Convention Center hotel
  • Gym is available on property
More Photos Photo of Comfort Suites near Texas Medical Center - NRG Stadium
From$80
Very Good 4.0 /5 Review Score Call BookMore Details
Staybridge Suites Houston - Medical Center, an IHG Hotel : 9000 South Main St.
+1-888-965-8297

How should we direct your call?

New Reservations: +1-888-965-8297 Group Sales: +1-888-494-8863
9000 South Main St., Houston, TX 77025 ~1.76 miles northwest of South Main
  • Mid-scale Downtown hotel
  • Complimentary breakfast is offered
More Photos Photo of Staybridge Suites Houston - Medical Center, an IHG Hotel
From$83
Average 3.0 /5 Review Score Call BookMore Details
More Homes & Apts at Booking.com

Book online or call +1-800-219-2797

Booking for Homes and Apartments
Go to BookingGo to Booking
Motel 6 Houston, TX - Medical Center/NRG Stadium - Houston
+1-888-906-6358

How should we direct your call?

New Reservations: +1-888-906-6358 Group Sales: +1-888-494-8863
3223 South Loop West, Houston, TX 77025 ~1.76 miles west of South Main
  • 2-star property
  • Hotel has 2 floors
More Photos Photo of Motel 6 Houston, TX - Medical Center/NRG Stadium
From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Studio 6 Houston Tx Medical Center Nrg Stadium
+1-888-749-6785

How should we direct your call?

New Reservations: +1-888-749-6785 Group Sales: +1-888-494-8863
3223 B South Loop West, Houston, TX 77025 ~1.77 miles west of South Main
  • Low-priced property
  • Check in time: 3:00 PM
More Photos Exterior of Studio 6 Houston Tx Medical Center Nrg Stadium
From$45
Poor 2.0 /5 Recent Reviews Call BookMore Details
Need some questions answered? Talk to an expert Hotel Planner: (855) 276-7561 or say...
alexa hotel planner skill"Alexa, ask Hotel Planner to make a new reservation near South Main" Get Alexa Skill →
Springhill Suites Marriott Medical Center Nrg Park - Houston
+1-888-878-9982

How should we direct your call?

New Reservations: +1-888-878-9982 Group Sales: +1-888-494-8863
1400 Old Spanish Trail, Houston, TX 77054 ~1.78 miles north of South Main
  • Three Star Downtown hotel
  • Comp. Breakfast
More Photos Exterior of Springhill Suites Marriott Medical Center Nrg Park
From$80
Average 3.0 /5 Guest Reviews Call BookMore Details
Sonder Nrg Park in Houston
+1-888-389-4485

How should we direct your call?

New Reservations: +1-888-389-4485 Group Sales: +1-888-494-8863
8700 South Main St., Houston, TX 77025 ~1.85 miles northwest of South Main
  • Three Star Downtown hotel
  • Check in: 4:00 PM
More Photos Exterior of Sonder Nrg Park
From$85
Average 3.0 /5 Latest Reviews Call BookMore Details
Hampton Inn & Suites Houston Medical Center Nrg Park in Houston
+1-888-389-4121

How should we direct your call?

New Reservations: +1-888-389-4121 Group Sales: +1-888-494-8863
1715 Old Spanish Trail, Houston, TX 77054 ~1.89 miles north of South Main
  • 3-star Convention Center property
  • Free comp. breakfast
More Photos Photo of Hampton Inn & Suites Houston Medical Center Nrg Park
From$69
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Residence Inn Houston Medical Center / Nrg Park : 7807 Kirby Dr.
+1-888-675-2083

How should we direct your call?

New Reservations: +1-888-675-2083 Group Sales: +1-888-494-8863
7807 Kirby Dr., Houston, TX 77030 ~1.93 miles north of South Main
  • 3-star Downtown hotel
  • 16 floors in hotel
More Photos Exterior of Residence Inn Houston Medical Center / Nrg Park
From$109
Very Good 4.0 /5 Latest Reviews Call BookMore Details
Americas Best Value Inn NRG Park Medical Center
+1-800-716-8490

How should we direct your call?

New Reservations: +1-800-716-8490 Group Sales: +1-888-494-8863
7905 South Main St., Houston, TX 77025 ~1.95 miles north of South Main
  • Economy Suburban property
  • 70 sleeping rooms in hotel
More Photos Image of Americas Best Value Inn NRG Park Medical Center
From$72
Average 3.0 /5 Read Reviews Call BookMore Details
Hotel Ylem
+1-800-805-5223

How should we direct your call?

New Reservations: +1-800-805-5223 Group Sales: +1-888-494-8863
8080 South Main St., Houston, TX 77025 ~1.95 miles north of South Main
  • Midscale Downtown property
  • 3 floors in property
More Photos Image of Hotel Ylem
From$80
Average 3.0 /5 Recent Reviews Call BookMore Details
Hyatt Place
+1-888-965-1860

How should we direct your call?

New Reservations: +1-888-965-1860 Group Sales: +1-888-494-8863
7329a Fannin St., Houston, TX 77030 ~1.96 miles north of South Main
  • Mid-scale hotel
More Photos hotel room
From$80
Average 3.0 /5 Latest Reviews Call BookMore Details
Hyatt Place Hyatt House Houston Medical Center - Houston
+1-888-788-5576

How should we direct your call?

New Reservations: +1-888-788-5576 Group Sales: +1-888-494-8863
7329 Fannin St., Houston, TX 77030 ~1.96 miles north of South Main
  • Midscale Suburban property
  • Complimentary breakfast is offered
More Photos Image of Hyatt Place Hyatt House Houston Medical Center
From$99
Average 3.0 /5 Latest Reviews Call BookMore Details
The Reside - Houston
+1-888-897-9207

How should we direct your call?

New Reservations: +1-888-897-9207 Group Sales: +1-888-494-8863
7755 South Main St., Houston, TX 77054 ~2.03 miles north of South Main
  • Mid-scale Downtown property
  • Hotel has 36 rooms
More Photos Image of The Reside
From$55
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Moody Manor - Houston
+1-888-311-4278

How should we direct your call?

New Reservations: +1-888-311-4278 Group Sales: +1-888-494-8863
7706 Main St., Houston, TX 77030 ~2.07 miles north of South Main
  • Affordable Downtown property
  • Check-in: 3:00pm
More Photos Image of Moody Manor
From$69
Average 3.5 /5 Latest Reviews Call BookMore Details

Next: Show All Available South Main Hotels with Pricing

Bar Chart: Upcoming 20 Days of South Main Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Southside Place, TX discounts available. The chart reflects the cheapest Southside Place hotel for each day and each star rating category.

What are the best hotels near South Main?

HotelDescriptionLink
1. Holiday Inn Houston S - Nrg Area - Medical Center, an IHG Hotel The Holiday Inn Houston S - Nrg Area - Medical Center, an IHG Hotel is a well-liked 3 star hotel located about 1.6 miles north of South Main and about a 3 min. drive by car. With a guest review score of 3.5 out of 5, this makes it one of the terrific lodging options near South Main. 3.5 /5 Guest Reviews

1 Best Hotels near South Main

FAQs about hotels near South Main

What are the top reviewed hotels near South Main?

Holiday Inn Express & Suites Houston S - Medical Ctr Area, Comfort Suites near Texas Medical Center - NRG Stadium and Hampton Inn & Suites Houston Medical Center Nrg Park are the best rated hotels based on customer reviews in the last 365 days.

What are the upper-end hotels near South Main?

Wyndham Houston near NRG Park, Wingate by Wyndham Near Nrg Park and Holiday Inn Houston S - Nrg Area - Medical Center, an IHG Hotel are the top 3 luxury hotels near South Main.

What hotels are closest to the area of South Main?

Bayou City Event Center, Wyndham Houston near NRG Park, and Quality Inn & Suites NRG Park - Medical Center are the properties closest to South Main.

How much does a cheap hotel near South Main cost per night?

In the last year, a 2 star hotel near South Main can be as cheap as $53.07 per night. (based on HotelPlanner prices)

How much does a 3 star hotel near South Main cost per night?

In the last year, the average 3 star hotel near South Main has been $91.80 per night. (based on HotelPlanner prices)

How much does a luxury hotel near South Main cost?

In the last year, the average 4 star hotel near South Main has been $104.50 per night. (based on HotelPlanner prices)

What are the most popular independent hotels near South Main?

The Reside, Moody Manor and Bayou City Event Center are the best rated independent hotels (not part of a big brand).

What are the best Marriott hotels near South Main?

Residence Inn Houston Medical Center and Springhill Suites Marriott Medical Center Nrg Park are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the most popular Choice Hotels branded hotels near South Main?

Comfort Suites near Texas Medical Center - NRG Stadium and Quality Inn & Suites NRG Park - Medical Center are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the most popular IHG hotels near South Main?

Holiday Inn Express & Suites Houston S - Medical Ctr Area, Holiday Inn Houston S - Nrg Area - Medical Center, an IHG Hotel and Candlewood Suites Houston Medical Center, an IHG Hotel are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

Back to Top