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65280 Hotels/Accommodations

America's Value Inn Mexico in Mexico
+1-888-389-4121
4224 South Clark St., Mexico, MO 65265 ~11.59 miles west of 65280
  • Low Cost Airport hotel
  • Check in time: 2:00 pm
From$35
Very Good 4.0 /5 Latest Reviews Call BookMore Details
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Days Inn by Wyndham Mexico : 2902 South Clark
+1-888-675-2083
2902 South Clark, Mexico, MO 65265 ~11.66 miles west of 65280
  • Cheap Suburban hotel
  • Free complimentary breakfast
From$60
Average 3.0 /5 Read Reviews Call BookMore Details
Best Western Teal Lake Inn
+1-800-716-8490
3602 South Clark St., Mexico, MO 65265 ~12.16 miles west of 65280
  • 3-star Suburban property
  • Check-in time: 03:00
From$65
Very Good 4.0 /5 Read Reviews Call BookMore Details
Country Hearth Inn & Suites Mexico - Mexico
+1-800-805-5223
900 Vance Rd., Mexico, MO 65265 ~12.90 miles west of 65280
  • Affordable Highway hotel
  • Free complimentary breakfast
From$44
Average 3.5 /5 Read Reviews Call BookMore Details
Baymont by Wyndham
+1-888-965-1860
5750 Jade Rd., Kingdom City, MO 65262 ~22.09 miles southwest of 65280
  • Economical hotel
  • Check in time: 3:00 PM
From$73
Average 3.0 /5 Review Score Call BookMore Details
Super 8 by Wyndham Kingdom City : 3370 Gold Ave.
+1-888-788-5576
3370 Gold Ave., Kingdom City, MO 65262 ~22.55 miles southwest of 65280
  • Two star Suburban property
  • Free breakfast
From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Quality Inn in Kingdom City
+1-888-897-9207
3207 County Rd. 211, Kingdom City, MO 65262 ~22.57 miles southwest of 65280
  • Midscale Highway hotel
  • Hotel has 59 rooms
From$80
Average 3.0 /5 Read Reviews Call BookMore Details
Holiday Inn Express & Suites Kingdom City, an IHG Hotel in Kingdom City
+1-888-311-4278
3257 County Rd. 211, Kingdom City, MO 65262 ~22.64 miles southwest of 65280
  • Low priced property
  • Fitness center on property
From$60
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Days Inn by Wyndham Kingdom City
+1-888-469-4795
3391 County Rd. 211, Kingdom City, MO 65262 ~22.69 miles southwest of 65280
  • Low priced Highway hotel
  • Check-in time: 15:00
From$60
Average 3.0 /5 Reviews Call BookMore Details
Americas Best Value Inn New Florence in New Florence
+1-888-734-9421
202 Clark Dr., New Florence, MO 63363 ~23.05 miles southeast of 65280
  • Cheap property
  • 2 floors in property
Knights Inn New Florence
+1-888-841-5292
403 Booneslick Rd., New Florence, MO 63363 ~23.11 miles southeast of 65280
  • Two star hotel
From$60
Average 3.0 /5 Reviews Call BookMore Details
America's Best Inn New Florence
+1-888-455-5160
1 Proactive Dr., New Florence, MO 63363 ~23.37 miles southeast of 65280
  • Two star property
From$60
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Baymont by Wyndham Fulton : 2205 Cardinal Dr.
+1-888-965-8297
2205 Cardinal Dr., Fulton, MO 65251 ~26.78 miles southwest of 65280
  • Affordable Rural property
  • Access to gym on-site
From$60
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Motel 70
+1-888-906-6358
930 Tree Farm Rd., High Hill, MO 65330 ~27.28 miles southeast of 65280
  • Cheap hotel
  • Check-in: 1:00 PM
From$30
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Super 8 by Wyndham Bowling Green
+1-888-749-6785
1216 East Champ Clark Dr., Bowling Green, MO 63334 ~28.26 miles east of 65280
  • 2 star Rural hotel
  • 64 rooms in hotel
From$56
Very Good 4.0 /5 Recent Reviews Call BookMore Details
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Amerihost Inn & Suites Fulton - Fulton
+1-888-878-9982
556 Amerihost Dr., Fulton, MO 65251 ~28.66 miles southwest of 65280
  • Economy Highway property
  • Fitness center on property
From$60
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
FairBridge Inn Express, Monroe City
+1-888-389-4485
3 Gateway Sq. Dr., Monroe City, MO 63456 ~32.31 miles north of 65280
  • 2 star Suburban property
  • Free breakfast available
From$60
Average 3.0 /5 Read Reviews Call BookMore Details
Super 8 by Wyndham Columbia East : 5700 Freedom Dr.
+1-888-389-4121
5700 Freedom Dr., Columbia, MO 65202 ~34.76 miles west of 65280
  • Two star Highway hotel
  • Comp. Breakfast
From$60
Average 3.0 /5 Reviews Call BookMore Details
Holiday Inn Columbia East, an IHG Hotel
+1-888-675-2083
915 Port Way, Columbia, MO 65201 ~34.92 miles west of 65280
  • Economical Suburban property
  • Check-in: 4:00PM
From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Hilton Garden Inn Columbia
+1-800-716-8490
3300 Vandiver Dr., Columbia, MO 65202 ~36.20 miles west of 65280
  • 3 star Suburban hotel
  • Check-in time: 3:00PM
From$93
Very Good 4.0 /5 Guest Reviews Call BookMore Details
Springhill Suites by Marriott Columbia
+1-800-805-5223
3415 Clark Lane, Columbia, MO 65202 ~36.29 miles west of 65280
  • Midscale Highway hotel
  • Gym is available on property
From$129
Average 3.0 /5 Recent Reviews Call BookMore Details
Residence Inn by Marriott Columbia in Columbia
+1-888-965-1860
1100 Woodland Springs Court, Columbia, MO 65202 ~36.30 miles west of 65280
  • Three Star Suburban hotel
  • Gym is available on property
From$80
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Candlewood Suites Columbia East, an IHG Hotel
+1-888-788-5576
1400 Creekwood Pkwy., Columbia, MO 65202 ~36.37 miles west of 65280
  • Low Cost Suburban property
  • Check-in time: 3:00pm
From$55
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Fairfield by Marriott : 1115 Woodland Springs Court
+1-888-897-9207
1115 Woodland Springs Court, Columbia, MO 65202 ~36.38 miles west of 65280
  • Mid-scale Highway property
  • 91 sleeping rooms in hotel
From$80
Average 3.0 /5 Hotel Reviews Call BookMore Details
Hampton Inn Columbia
+1-888-311-4278
3410 Clark Lane, Columbia, MO 65202 ~36.44 miles west of 65280
  • Affordable Highway hotel
  • Gym is available on property
From$109
Very Good 4.0 /5 Reviews Call BookMore Details
Motel 6 Columbia East Mo
+1-888-469-4795
3402 Interstate 70 Dr. Southeast, Columbia, MO 65201 ~36.44 miles west of 65280
  • Low-priced property
  • 61 sleeping rooms in hotel
From$60
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Super 8 by Wyndham Columbia Clark Lane
+1-888-734-9421
3216 Clark Lane, Columbia, MO 65202 ~36.53 miles west of 65280
  • Low Cost Highway hotel
  • Hotel has 6 suites
Staybridge Suites Columbia, an IHG Hotel - Columbia
+1-888-841-5292
805 Keene St., Columbia, MO 65201 ~36.60 miles west of 65280
  • 3 star Suburban property
  • Free comp. breakfast
From$66
Very Good 4.5 /5 Read Reviews Call BookMore Details
Quality Inn & Suites Columbia I-70 : 801 Keene St.
+1-888-455-5160
801 Keene St., Columbia, MO 65201 ~36.60 miles west of 65280
  • Economy Downtown property
  • Has environment-friendly policy See policy
From$60
Average 3.0 /5 Guest Reviews Call BookMore Details
Howard Johnson Inn Columbia
+1-888-965-8297
3100 I 70 Dr. Southeast, Columbia, MO 65201 ~36.62 miles west of 65280
  • Inexpensive Highway hotel
  • Access to gym on-site
From$60
Average 3.0 /5 Reviews Call BookMore Details
Drury Plaza Hotel Columbia East - Columbia
+1-888-906-6358
3100 Interstate 70 Dr. Se, Columbia, MO 65201 ~36.63 miles west of 65280
  • Three Star Suburban hotel
  • Complimentary breakfast is offered
From$136
Average 3.0 /5 Hotel Reviews Call BookMore Details
Country Inn & Suites by Radisson, Columbia, MO : 817 North Keene St.
+1-888-749-6785
817 North Keene St., Columbia, MO 65201 ~36.67 miles west of 65280
  • Midscale Highway hotel
  • Free complimentary breakfast
From$80
Very Good 4.5 /5 Latest Reviews Call BookMore Details
Quality Inn & Suites Columbia I-70 : 801 North Keene St.
+1-888-878-9982
801 North Keene St., Columbia, MO 65201 ~36.71 miles west of 65280
  • Three Star Downtown hotel
  • Hotel has an eco-friendly policy Learn more
From$52
Average 3.5 /5 Review Score Call BookMore Details
Best Western Plus Columbia Inn in Columbia
+1-888-389-4485
2904 Clark Ln, Columbia, MO 65202 ~36.74 miles west of 65280
  • 2 star Suburban property
  • Has environment-friendly policy Learn more
From$80
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Wingate by Wyndham - Columbia in Columbia
+1-888-389-4121
3101 Wingate Court, Columbia, MO 65201 ~36.78 miles west of 65280
  • Midscale Highway hotel
  • 81 sleeping rooms in hotel
From$89
Very Good 4.0 /5 Read Reviews Call BookMore Details
Ramada Inn & Suites in Columbia
+1-888-675-2083
901 Conley Rd., Columbia, MO 65201 ~36.83 miles west of 65280
  • Low-priced Highway hotel
  • Hotel has 28 suites
From$54
Average 3.5 /5 Latest Reviews Call BookMore Details
Baymont by Wyndham Hannibal - Hannibal
+1-800-716-8490
4141 Market St., Hannibal, MO 63401 ~37.02 miles northeast of 65280
  • Two-star Convention Center hotel
  • Gym is available on property
From$35
Average 3.0 /5 Latest Reviews Call BookMore Details
Days Inn by Wyndham Hannibal in Hannibal
+1-800-805-5223
4070 Market St., Hannibal, MO 63401 ~37.06 miles northeast of 65280
  • 2 star hotel
  • 63 sleeping rooms in hotel
From$60
Average 3.0 /5 Hotel Reviews Call BookMore Details
Comfort Inn & Suites - Hannibal
+1-888-965-1860
4000 Market St., Hannibal, MO 63401 ~37.10 miles northeast of 65280
  • Inexpensive Highway hotel
  • Access to gym on-site
From$75
Very Good 4.0 /5 Recent Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites Columbia Univ Area-Hwy 63, an
+1-888-788-5576
1402 Cinnamon Hill Lane, Columbia, MO 65201 ~37.59 miles west of 65280
  • 3-star Highway hotel
  • Fitness + Health Center
From$80
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Budget Host Inn - Columbia
+1-888-897-9207
900 Vandiver Dr., Columbia, MO 65202 ~38.13 miles west of 65280
  • Low Cost Highway hotel
  • 2 floors in hotel
From$40
Average 3.0 /5 Guest Reviews Call BookMore Details
Motel 6 Hannibal, MO in Hannibal
+1-888-311-4278
123 Huckleberry Heights Dr., Hannibal, MO 63401 ~38.16 miles northeast of 65280
  • Low-priced property
  • Check in time: 14:00
From$60
Average 3.5 /5 Reviews Call BookMore Details
Super 8 by Wyndham Hannibal : 120 Huckleberry Heights Dr.
+1-888-469-4795
120 Huckleberry Heights Dr., Hannibal, MO 63401 ~38.21 miles northeast of 65280
  • 2 star Highway property
  • 2 floors in property
From$60
Average 3.0 /5 Latest Reviews Call BookMore Details
Sleep Inn & Suites
+1-888-734-9421
105 Lakeside Dr., Hannibal, MO 63401 ~38.23 miles north of 65280
  • Low priced hotel
  • Fitness + Health Center
From$109
Very Good 4.0 /5 Reviews Call BookMore Details
Courtyard by Marriott Columbia Missouri - Columbia
+1-888-841-5292
3301 Lemone Industrial Blvd., Columbia, MO 65201 ~38.29 miles southwest of 65280
  • 3-star Highway property
  • 4 suites in property
From$99
Very Good 4.5 /5 Hotel Reviews Call BookMore Details
Baymont by Wyndham Warrenton in Warrenton
+1-888-455-5160
425 East Veterans Memorial Pkwy., Warrenton, MO 63383 ~38.55 miles southeast of 65280
  • 2-star Rural property
  • 62 rooms in property
From$60
Average 3.0 /5 Recent Reviews Call BookMore Details
TownePlace Suites by Marriott Columbia
+1-888-965-8297
4400 Nocona Pkwy., Columbia, MO 65201 ~38.55 miles southwest of 65280
  • Midscale hotel
  • Access to gym on-site
From$85
Average 3.0 /5 Reviews Call BookMore Details
Quality Inn & Suites Hannibal
+1-888-906-6358
120 Lindsey Dr., Hannibal, MO 63401 ~38.55 miles north of 65280
  • 3-star hotel
  • Gym / Fitness Center Available
From$67
Very Good 4.0 /5 Hotel Reviews Call BookMore Details
Red Roof Inn Columbia, MO
+1-888-749-6785
201 East Texas Ave., Columbia, MO 65202 ~38.57 miles west of 65280
  • 3-star Suburban property
  • 2 floors in hotel
From$44
Average 3.0 /5 Review Score Call BookMore Details
The Broadway Columbia a Doubletree by Hilton - Columbia
+1-888-878-9982
1111 East Broadway, Columbia, MO 65201 ~38.59 miles west of 65280
  • High end Downtown property
  • 6 floors in hotel
From$143
Very Good 4.0 /5 Reviews Call BookMore Details

Next: Show All Available 65280 Hotels with Pricing

Graph: Upcoming 20 Days of 65280 Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Mexico, MO discounts available. The chart reflects the cheapest Mexico hotel for each day and each star rating category.

FAQs about hotels near 65280

What are the top rated hotels near 65280?

Staybridge Suites Columbia, an IHG Hotel, Country Inn & Suites by Radisson, Columbia, MO and Courtyard by Marriott Columbia Missouri are the best rated hotels based on customer reviews in the last 365 days.

What are the most high-end hotels near 65280?

The Broadway Columbia a Doubletree by Hilton, Best Western Teal Lake Inn and Country Hearth Inn & Suites Mexico are the top 3 luxury hotels near 65280.

What hotels are closest to the area of 65280?

America's Value Inn Mexico, Days Inn by Wyndham Mexico, and Best Western Teal Lake Inn are the properties closest to 65280.

How much does a cheap hotel near 65280 cost per night?

In the last year, a 2 star hotel near 65280 can be as cheap as $63.47 per night. (based on HotelPlanner prices)

How much does a 3 star hotel near 65280 cost per night?

In the last year, the average 3 star hotel near 65280 has been $98.83 per night. (based on HotelPlanner prices)

How much does a higher-end hotel near 65280 cost?

In the last year, the average 4 star hotel near 65280 has been $160.00 per night. (based on HotelPlanner prices)

What are the most popular independent hotels near 65280?

Staybridge Suites Columbia, an IHG Hotel, America's Value Inn Mexico and America's Best Inn New Florence are the best rated independent hotels (not part of a big brand).

What are the best Marriott hotels near 65280?

Courtyard by Marriott Columbia Missouri, Residence Inn by Marriott Columbia and Springhill Suites by Marriott Columbia are the best rated Marriott/Starwood branded hotels (based on customer reviews score).

What are the best Choice Hotels branded hotels near 65280?

Comfort Inn & Suites - Hannibal, Sleep Inn & Suites and Quality Inn & Suites Hannibal are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the best Best Western hotels near 65280?

Best Western Teal Lake Inn and Best Western Plus Columbia Inn are the best rated Best Western branded hotels (based on user reviews score).

What are the most popular IHG hotels near 65280?

Holiday Inn Express & Suites Kingdom City, an IHG Hotel, Candlewood Suites Columbia East, an IHG Hotel and Holiday Inn Express Hotel & Suites Columbia Univ Area-Hwy 63, an are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

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