Seneca South Carolina Hotels & Motels

Only hotels in Seneca are listed below. Search for cheap and discounted hotel and motel rates in or near Seneca, SC for your upcoming personal or group trip. We provide the best Seneca, South Carolina motel and hotel rooms. Browse the Seneca area hotels to find the perfect lodging! Please use the provided map of the Seneca hotels. Group booking? Search Seneca Group Hotel Discounts

The Seneca center point is about 6 miles west of Memorial Stadium and 6 miles west of Clemson Amtrak Station.

Known for its friendly atmosphere and small-town charm, Seneca, South Carolina, is just 10 miles west of Clemson. Whether you're visiting for work or fun, you'll appreciate the city's welcoming vibe, historic district, and beautiful setting. Get to know the City of Smiles and find out where to stay in Seneca. More from this guide...

Seneca Hotels, Motels & Accommodations

Best Western Seneca-Clemson in Seneca
+1-888-389-4121
511 Bypass Highway 123, Seneca, SC 29678 +1-888-389-4121
  • Mid-scale Rural property
  • 57 sleeping rooms in hotel
From£79
Very good 4.0 /5 Reviews Call BookMore Details
Fairfield Inn & Suites by Marriott Seneca Clemson Univ Area in Seneca
+1-888-675-2083
800 Us 123, Seneca, SC 29678 +1-888-675-2083
  • Cheap Rural property
  • 4 floors in hotel
From£47
Average 3.0 /5 Hotel Reviews Call BookMore Details
Hampton Inn & Suites Seneca Clemson Area Sc
+1-800-716-8490
1011 East North 1st St., Seneca, SC 29678 +1-800-716-8490
  • Affordable property
  • Fitness center on property
From£102
Very good 4.5 /5 Read Reviews Call BookMore Details
Days Inn by Wyndham Seneca / Clemson Area : 11015 North Radio Station Rd.
+1-800-805-5223
11015 North Radio Station Rd., Seneca, SC 29678 +1-800-805-5223
  • Inexpensive hotel
  • Check-in time: 2:00
From£47
Average 3.0 /5 Recent Reviews Call BookMore Details
Quality Inn Seneca US-123
+1-888-965-1860
226 Hitec Rd., Seneca, SC 29678 +1-888-965-1860
  • Midscale Lake property
  • Free complimentary breakfast
From£60
Very good 4.0 /5 Latest Reviews Call BookMore Details
TRU by Hilton Seneca Clemson
+1-888-788-5576
13050 Clemson Blvd., Seneca, SC 29678 +1-888-788-5576
  • Midscale Lake property
  • Fitness + Health Center
From£47
Very good 4.0 /5 Recent Reviews Call BookMore Details
Hampton Inn - Clemson
+1-888-897-9207
851 Tiger Blvd., Clemson, SC 29631 +1-888-897-9207 ~5.99 miles east of Seneca
  • Midscale Suburban property
  • Free breakfast available
From£83
Very good 4.0 /5 Review Score Call BookMore Details
Holiday Inn Express & Suites (Clemson University & Seneca Area) - Clemson
+1-888-311-4278
1381 Tiger Blvd., Clemson, SC 29631 +1-888-311-4278 ~6.80 miles east of Seneca
  • 3 star Downtown property
  • Free complimentary breakfast
From£86
Very good 4.5 /5 Hotel Reviews Call BookMore Details
Inn at Clemson
+1-888-469-4795
1303 Tiger Blvd., Clemson, SC 29631 +1-888-469-4795 ~6.80 miles east of Seneca
  • Low priced property
  • Fitness / Gym is on-site
From£60
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Days Inn by Wyndham Clemson - Clemson
+1-888-734-9421
1387 Tiger Blvd., Clemson, SC 29631 +1-888-734-9421 ~6.80 miles east of Seneca
  • Inexpensive property
  • Complimentary breakfast is offered
From£47
Average 3.0 /5 Review Score Call BookMore Details
Comfort Inn & Suites Clemson - University Area in Clemson
+1-888-841-5292
1305 Tiger Blvd., Clemson, SC 29631 +1-888-841-5292 ~7.12 miles east of Seneca
  • Affordable Downtown property
  • Comp. Breakfast
From£63
Very good 4.0 /5 Recent Reviews Call BookMore Details
Best Western Plus Clemson Hotel & Conference Center : 1310 Tiger Blvd.
+1-888-455-5160
1310 Tiger Blvd., Clemson, SC 29631 +1-888-455-5160 ~7.28 miles east of Seneca
  • Two star Downtown property
  • Check in: 3:00 PM
From£67
Very good 4.0 /5 Latest Reviews Call BookMore Details
Rodeway Inn & Suites
+1-888-965-8297
901 East Main St., Walhalla, SC 29691 +1-888-965-8297 ~7.87 miles northwest of Seneca
  • Cheap Mountain hotel
  • 18 rooms in hotel
From£39
Very good 4.0 /5 Review Score Call BookMore Details
Courtyard Marriott Clemson
+1-888-906-6358
201 Canoy Lane, Clemson, SC 29631 +1-888-906-6358 ~7.93 miles east of Seneca
  • 3-star hotel
  • Hotel has 5 suites
From£90
Very good 4.0 /5 Recent Reviews Call BookMore Details
Econo Lodge in Clemson
+1-888-749-6785
106 Liberty Dr., Clemson, SC 29631 +1-888-749-6785 ~8.08 miles east of Seneca
  • 2 star property
From£47
Very good 4.0 /5 Recent Reviews Call BookMore Details
The Inn at Patrick Square - Clemson
+1-888-878-9982
115 Market St., Clemson, SC 29631 +1-888-878-9982 ~9.47 miles east of Seneca
  • Affordable Suburban property
  • Check in time: 4:00 PM
From£63
Average 3.0 /5 Read Reviews Call BookMore Details
Hampton Inn Anderson : 120 Insterstate Blvd.
+1-888-389-4485
120 Insterstate Blvd., Anderson, SC 29621 +1-888-389-4485 ~13.07 miles southeast of Seneca
  • Midscale Highway hotel
  • 3 floors in property
From£67
Average 3.0 /5 Hotel Reviews Call BookMore Details
Microtel Inn & Suites by Wyndham Anderson/Clemson - Anderson
+1-888-389-4121
102 Electric City Blvd., Anderson, SC 29621 +1-888-389-4121 ~15.54 miles east of Seneca
  • Low Cost Highway property
  • Check-in: 3:00PM
From£46
Average 3.0 /5 Read Reviews Call BookMore Details
Country Inn & Suites by Radisson, Anderson, SC
+1-888-675-2083
116 Interstate Blvd., Anderson, SC 29621 +1-888-675-2083 ~15.61 miles east of Seneca
  • 3-star Highway property
  • Free breakfast available
From£51
Very good 4.0 /5 Latest Reviews Call BookMore Details
Fairfield Inn & Suites by Marriott Anderson Clemson
+1-800-716-8490
117 Interstate Blvd., Anderson, SC 29621 +1-800-716-8490 ~15.61 miles east of Seneca
  • Mid-scale hotel
  • Hotel has 3 floors
From£71
Very good 4.0 /5 Read Reviews Call BookMore Details
Holiday Inn Express & Suites : 107 Interstate Blvd.
+1-800-805-5223
107 Interstate Blvd., Anderson, SC 29621 +1-800-805-5223 ~15.64 miles east of Seneca
  • Midscale Highway hotel
  • 17 suites in property
From£63
Very good 4.0 /5 Recent Reviews Call BookMore Details
Comfort Suites Anderson-Clemson : 118 Interstate Blvd.
+1-888-965-1860
118 Interstate Blvd., Anderson, SC 29621 Website +1-888-965-1860 ~15.73 miles east of Seneca
  • Low-priced Highway hotel
  • Hotel has 60 suites
From£51
Average 3.0 /5 Reviews Call BookMore Details
Rodeway Inn - Anderson
+1-888-788-5576
4515 Clemson Blvd., Anderson, SC 29621 +1-888-788-5576 ~15.94 miles southeast of Seneca
  • Inexpensive property
  • 50 rooms in property
From£47
Very good 4.0 /5 Reviews Call BookMore Details
Baymont by Wyndham Anderson Clemson in Anderson
+1-888-897-9207
128 Interstate Blvd., Anderson, SC 29621 +1-888-897-9207 ~15.97 miles east of Seneca
  • Inexpensive Highway property
  • Access to gym on-site
From£39
Average 3.0 /5 Guest Reviews Call BookMore Details
Days Inn by Wyndham Anderson - Anderson
+1-888-311-4278
1007 Smith Mill Rd., Anderson, SC 29625 +1-888-311-4278 ~16.04 miles southeast of Seneca
  • Two star Highway property
  • Check-in: 11:00 AM
From£39
Average 3.0 /5 Reviews Call BookMore Details
Hilton Garden Inn Anderson
+1-888-469-4795
115 Destination Blvd., Anderson, SC 29621 +1-888-469-4795 ~16.11 miles southeast of Seneca
  • Three Star Highway hotel
  • 124 sleeping rooms in hotel
From£63
Very good 4.0 /5 Read Reviews Call BookMore Details
Americas Best Value Inn Anderson, SC in Anderson
+1-888-734-9421
4020 Clemson Blvd., Anderson, SC 29621 +1-888-734-9421 ~17.45 miles southeast of Seneca
  • Two star Suburban hotel
  • Free comp. breakfast
From£42
Average 3.0 /5 Reviews Call BookMore Details
Holiday Inn Anderson, an IHG Hotel in Anderson
+1-888-841-5292
3509 Clemson Blvd., Anderson, SC 29621 +1-888-841-5292 ~18.40 miles southeast of Seneca
  • 3 star Downtown property
  • Access to gym on-site
From£67
Very good 4.5 /5 Hotel Reviews Call BookMore Details
Super 8 by Wyndham Anderson/Clemson Area
+1-888-455-5160
3302 Cinema Ave., Anderson, SC 29621 +1-888-455-5160 ~18.57 miles southeast of Seneca
  • Inexpensive hotel
  • Check in: 11:00 AM
From£47
Average 3.5 /5 Read Reviews Call BookMore Details
Quality Inn Clemson Near University - Anderson
+1-888-965-8297
3430 Clemson Blvd., Anderson, SC 29621 +1-888-965-8297 ~18.61 miles southeast of Seneca
  • Low-priced Suburban property
  • Gym is available on property
From£47
Average 3.0 /5 Read Reviews Call BookMore Details
Days Inn by Wyndham Lavonia - Lavonia
+1-888-906-6358
13705 Jones St., Lavonia, GA 30553 +1-888-906-6358 ~19.09 miles southwest of Seneca
  • 2 star Highway property
  • Free breakfast available
From£47
Very good 4.0 /5 Review Score Call BookMore Details
Super 8 by Wyndham Lavonia - Lavonia
+1-888-749-6785
14227 Jones St., Lavonia, GA 30553 +1-888-749-6785 ~19.12 miles southwest of Seneca
  • 2-star Highway property
  • Check in: 11:00 AM
From£47
Average 3.0 /5 Reviews Call BookMore Details
Quality Inn
+1-888-878-9982
890 Ross Place, Lavonia, GA 30553 +1-888-878-9982 ~19.18 miles southwest of Seneca
  • Economy hotel
  • Check-in: 11:00
From£34
Average 3.0 /5 Hotel Reviews Call BookMore Details
Horizon Inn & Suites : 3025 North Main St.
+1-888-389-4485
3025 North Main St., Anderson, SC 29621 +1-888-389-4485 ~19.24 miles southeast of Seneca
  • Inexpensive Downtown property
  • Check-in time: 3:00 PM
From£47
Average 3.0 /5 Latest Reviews Call BookMore Details
Holiday Inn Express Hotel & Suites Lavonia, an IHG Hotel - Lavonia
+1-888-389-4121
110 Owens Dr., Lavonia, GA 30553 +1-888-389-4121 ~19.25 miles southwest of Seneca
  • Affordable Rural hotel
  • Hotel has 72 rooms
From£87
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Hampton Inn & Suites Lavonia
+1-888-675-2083
115 Owens Dr., Lavonia, GA 30553 +1-888-675-2083 ~19.32 miles southwest of Seneca
  • Midscale Rural hotel
  • 4 floors in hotel
From£87
Very good 4.0 /5 Guest Reviews Call BookMore Details
Holiday Inn Express Anderson An Ihg Hotel - Anderson
+1-800-716-8490
410 Alliance Pkwy., Anderson, SC 29621 +1-800-716-8490 ~20.49 miles east of Seneca
  • Low-priced Highway hotel
  • 12 suites in hotel
From£47
Very good 4.0 /5 Latest Reviews Call BookMore Details
Hampton Inn Anderson/ Alliance Business Park - Anderson
+1-800-805-5223
411 Alliance Pkwy., Anderson, SC 29621 +1-800-805-5223 ~20.50 miles east of Seneca
  • Cheap Highway hotel
  • Fitness / Gym is on-site
From£67
Very good 4.0 /5 Reviews Call BookMore Details
Quality Inn : 106 Stephen Circle
+1-888-965-1860
106 Stephen Circle, Toccoa, GA 30577 +1-888-965-1860 ~21.80 miles west of Seneca
  • Two star Downtown hotel
  • Access to gym on-site
From£39
Average 3.0 /5 Read Reviews Call BookMore Details
Country Hearth Inn & Suites Toccoa in Toccoa
+1-888-788-5576
273 North Brd. St., Toccoa, GA 30577 +1-888-788-5576 ~22.81 miles west of Seneca
  • Cheap property
  • 40 rooms in hotel
From£42
Very good 4.0 /5 Recent Reviews Call BookMore Details
Hampton Inn Hartwell
+1-888-897-9207
1357 East Franklin St., Hartwell, GA 30643 +1-888-897-9207 ~22.96 miles south of Seneca
  • Affordable Rural property
  • Hotel has 9 suites
From£78
Very good 4.0 /5 Recent Reviews Call BookMore Details
Quality Inn Hartwell
+1-888-311-4278
1091 East Franklin St., Hartwell, GA 30643 +1-888-311-4278 ~22.98 miles south of Seneca
  • 3 star Downtown property
  • Free breakfast
From£48
Very good 4.0 /5 Review Score Call BookMore Details
Days Inn by Wyndham Easley/Greenville/Clemson Area : 121 Days Inn Dr.
+1-888-469-4795
121 Days Inn Dr., Easley, SC 29640 +1-888-469-4795 ~23.82 miles east of Seneca
  • Two star Downtown property
  • 7 suites in property
From£31
Average 3.0 /5 Reviews Call BookMore Details
Quality Inn & Suites : 5539 Calhoun Memorial Highway
+1-888-734-9421
5539 Calhoun Memorial Highway, Easley, SC 29640 Website +1-888-734-9421 ~23.96 miles east of Seneca
  • Cheap property
  • 2 meeting rooms in hotel
From£55
Average 3.0 /5 Reviews Call BookMore Details
Baymont by Wyndham Easley/Greenville
+1-888-841-5292
211 Dayton School Rd., Easley, SC 29642 +1-888-841-5292 ~24.56 miles east of Seneca
  • Low priced Highway property
  • Check-in time: 11:00 AM
From£49
Average 3.0 /5 Guest Reviews Call BookMore Details
Hampton Inn Easley - Easley
+1-888-455-5160
8 Southern Center Court, Easley, SC 29642 +1-888-455-5160 ~25.79 miles east of Seneca
  • Three Star Suburban hotel
  • Free breakfast
From£79
Very good 4.5 /5 Recent Reviews Call BookMore Details
Kingwood Resort
+1-888-965-8297
401 Country Club Dr., Clayton, GA 30525 +1-888-965-8297 ~26.30 miles west of Seneca
  • 3 star Resort hotel
  • Gym is available on property
From£63
Very good 4.0 /5 Recent Reviews Call BookMore Details
Super 8 by Wyndham Piedmont Greenville Area
+1-888-906-6358
3104 Highway 153, Piedmont, SC 29673 +1-888-906-6358 ~28.23 miles east of Seneca
  • Two star Highway hotel
  • Check-in: 2:00PM
From£47
Very good 4.0 /5 Read Reviews Call BookMore Details
Best Western Plus Greenville South in Piedmont
+1-888-749-6785
70 Kalyns Way, Piedmont, SC 29673 +1-888-749-6785 ~28.32 miles east of Seneca
  • Three Star Highway property
  • Hotel has 13 suites
From£58
Very good 4.0 /5 Review Score Call BookMore Details
Comfort Suites Greenville South : 10 Kalyns Way
+1-888-878-9982
10 Kalyns Way, Piedmont, SC 29673 Website +1-888-878-9982 ~28.33 miles east of Seneca
  • Three Star Highway hotel
  • 82 sleeping rooms in hotel
From£55
Very good 4.0 /5 Hotel Reviews Call BookMore Details

Next: See My Seneca Hotels with Pricing

When should you visit Seneca, SC?

To experience the city at its liveliest, don't miss Seneca Fest. This annual event takes place at the end of May and features a full lineup of musical performances, action-packed wrestling matches, and family-friendly activities.

To plan your trip around the area's best weather, consider visiting during the spring or fall when high temperatures usually top out in the low 80s or high 70s. Summers can get very hot in Seneca, with highs in the 90s, and winters can get chilly, with lows around 30. Although August tends to be the wettest month of the year, winter is rainy season in Seneca. If you visit during the winter, bundle up and wear a waterproof jacket to stay warm and dry.

Winter is low season in Seneca, and you're most likely to find great discounts on hotels in January or February. For low rates on accommodations during high season, start planning in advance, and look for group rates.

What hotels in Seneca, SC offer the best discounts?

Looking for the best deals and discounts on Seneca hotels? Browse some of the best group rates in the area.

Senior travelers and AARP members can get discounts at the Best Western Executive Inn in Seneca. This centrally located hotel has both suites and standard rooms, and you'll appreciate the outdoor pool and the complimentary breakfast served each morning.

AAA members can get low rates at the Baymont Inn & Suites in Anderson. This mid-range hotel has a long list of extras, including free breakfast, a fitness center, an outdoor pool, and a meeting room available for reservation.

Government employees and members of the military can save at the Rodeway Inn in nearby Anderson. This budget-friendly hotel has 50 affordable rooms with basics like mini-fridges, microwaves, and coffee makers, and the hotel offers easy access to Interstate 85.

Where are the hotels with the most value in Seneca, South Carolina

It's easy to balance price with amenities when you book one of the best value options in Seneca. Take a look at the area's best mid-range hotels.

When you want to stay in the heart of Seneca, the Quality Inn offers plenty of value in a convenient location. This mid-range hotel has over 60 well-equipped guest rooms, along with a fitness center, an outdoor pool, and free Wi-Fi. You'll love the signature Q Beds, and after a great night's sleep, you'll be ready to dig into the complimentary breakfast spread. This Quality Inn welcomes up to two pets per room, making it easy to travel with your furry family members.

Nestled in nearby Clemson, the Best Western Plus University Inn & Conference Center is a smart choice for both leisure and business travelers. Settle into your modern guest room, grab a bite to eat at the full-service restaurant, and catch up on work in the business center. This Best Western also has six available conference rooms and an average group discount of over 20 percent, making this mid-range hotel excellent for groups visiting the Seneca area.

Also located in Clemson, Comfort Inn Clemson SC (Clemson University & Seneca Area) features three meeting rooms and an average group discount of over 15 percent. This mid-range hotel has guest rooms equipped with microwaves, coffee makers, and mini-fridges as well as an outdoor pool that's ideal for cooling off on a hot summer day. In the morning, don't miss the free breakfast bar, which includes biscuits and gravy, fresh waffles, pastries, and coffee.

What can't-miss attractions should you see in Seneca, SC?

With its equal doses of historical charm and natural beauty, Seneca has a little something for every visitor. Take a stroll through the Seneca Historic District to enjoy this South Carolina gem's small-town appeal and marvel at the many homes and churches that date back to the 19th century.

Located in the heart of the Seneca Historic District, the Lunney House Museum is an essential stop for history buffs. A stunning example of the architecture that defined the New South in the early 20th century, this home features impressive details like a sparkling chandelier, an intricately carved oak mantel, a 19th-century grand piano, and art glass windows. Take a self-guided tour of the house museum or check the museum's calendar for special events.

To gain a more comprehensive picture of Seneca's history, you'll also want to visit the Bertha Lee Strickland Cultural Museum. This fascinating museum explores the history of African-American culture and Oconee County residents through a variety of permanent and temporary exhibitions.

If you're traveling with kids in tow, you'll also want to visit the World of Energy at Oconee Nuclear. This interactive museum is a fun place for kids of all ages to learn about electricity, energy, and local nature and wildlife.

Next, experience Seneca's natural beauty firsthand with a visit to South Cove County Park. Located on the shores of Lake Keowee, this park is perfect for swimming, sunbathing, boating, and fishing. You can also take advantage of the tennis courts, picnic areas, and playgrounds all year round. If you didn't bring your own boat, you'll find canoe, kayak, and pontoon boat rentals at Lake Keowee Marina and many other local spots.

Why wait to book your trip? Find the ideal place to stay and start designing your Seneca itinerary.

What did travelers think of the city of Seneca?

Below are reviews of the city of Seneca, SC from an actual visitor's perspective.

"The View!"
Score 4.0 / 5

The view!

Tammy S., from 25-Jun-2024
"Beautiful Water Views!"
Score 5.0 / 5

Beautiful views of water!

Tammy S., from 25-Jun-2024
"Convenient to Shops & Restaurants"
Score 5.0 / 5

The shops and restaurants being close to the hotel was very convenient.

Kristin M., from 23-Jun-2024
"Nostalgic Drive-In and Jazz"
Score 5.0 / 5

We were given a recommendation for a great burger joint. Time Drive-In! Suggest y'all check it out. It was a throw back to when burgers were good and service meant something! Seneca is a fun town to walk in the downtown area, lots to see. Thursday night jazz was fun.

Kelly J., from 16-Jun-2024
"Nice City"
Score 5.0 / 5

It's a nice city.

Richard S., from 17-Dec-2023
"Nice town and great restaurant!"
Score 5.0 / 5

Nice and clean little town and a great restaurant, Seneca family restaurant.

Warren C., from 14-Oct-2023
"Good Location"
Score 5.0 / 5

The hotel was easy to find.

Dwight H., from 29-Sep-2023
"Great Places to Eat!"
Score 4.0 / 5

Friendly people and great places to eat. Example, Blue Marble Deli and Tipsy Taco.

Andrew S., from 14-May-2023
"Very Pretty Area"
Score 5.0 / 5

Very pretty area!

Debora L., from 15-Apr-2023
"Nice Place & Good Restaurants"
Score 5.0 / 5

Nice place to visit. Good restaurants.

Barry P., from 27-Mar-2023
"Nice Small Town "
Score 5.0 / 5

Seneca is a very nice small town. It has what you need for a short visit.

Jerry A., from 21-Mar-2023
"Nice Place"
Score 4.0 / 5

Nice place and good place to visit.

Peter B., from 15-Oct-2022
"Central to Lake Hartwell, Lake Jocassee & Lake Keowee"
Score 4.0 / 5

The main reason I like Seneca is the city's central proximity to Lake Hartwell, Lake Jocassee, and Lake Keowee.

John M., from 26-Jun-2022
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