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Desoto Missouri Accommodations

Find hotels in Desoto using the list and search tools below. Search for the cheapest discounted hotel and motel rates in or near Desoto, MO for your corporate or personal leisure travel. We show the best Desoto Missouri hotel rooms. Review the Desoto hotel list below to find the perfect lodging. We also have a map of the Desoto hotels.

Desoto Hotels/Motels & Accommodations

Holiday Inn Club Vac Timber Creek in Desoto
+1-888-389-4121
4800 Us Highway 67, Desoto, MO 63020
  • Mid-scale hotel
  • Gym is available on property
From£71
Very good 4.5 /5 Read Reviews Call BookMore Details
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Holiday Inn Express Hotel & Suites Festus South St. Louis An I : 1802 Gamel Cemetery Rd.
+1-888-675-2083
1802 Gamel Cemetery Rd., Festus, MO 63028 ~9.29 miles northeast of Desoto
  • Low priced Highway hotel
  • Check-in: 3:00pm
From£71
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Comfort Inn Festus - St Louis South
+1-800-716-8490
1303 Veterans Blvd., Festus, MO 63028 Website ~9.49 miles northeast of Desoto
  • 3 star Suburban hotel
  • Hotel has 3 floors
From£35
Very good 4.0 /5 Read Reviews Call BookMore Details
Quality Inn Festus
+1-800-805-5223
1200 West Gannon Dr., Festus, MO 63028 Website ~9.52 miles northeast of Desoto
  • Mid-scale Suburban hotel
  • Hotel has 7 meeting rooms
From£57
Average 3.0 /5 Guest Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
+1-888-965-1860
1001 Veterans Blvd., Festus, MO 63028 ~9.71 miles northeast of Desoto
  • Three Star Suburban hotel
  • Free complimentary breakfast
From£63
Average 3.0 /5 Review Score Call BookMore Details
Super 8 by Wyndham Pevely
+1-888-788-5576
1711 Highway Z, Pevely, MO 63070 ~13.04 miles northeast of Desoto
  • Cheap property
  • Check-in time: 11:00 AM
From£27
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Super 8 by Wyndham Bonne Terre in Bonne Terre
+1-888-897-9207
8 Northwood Dr., Bonne Terre, MO 63628 ~14.95 miles south of Desoto
  • Two star property
  • Check in: 11:00 AM
From£47
Average 3.0 /5 Reviews Call BookMore Details
Motel 6 Bonne Terre Mo
+1-888-311-4278
1017 Highway K, Bonne Terre, MO 63628 ~15.14 miles south of Desoto
  • Low Cost property
From£47
Average 3.0 /5 Guest Reviews Call BookMore Details
Super 8 by Wyndham Potosi in Potosi
+1-888-469-4795
820 East High St., Potosi, MO 63664 ~18.93 miles southwest of Desoto
  • Low Cost Highway property
  • 48 sleeping rooms in hotel
From£38
Average 3.0 /5 Read Reviews Call BookMore Details
Quality Inn & Suites
+1-888-734-9421
3610 West Outer Rd., Arnold, MO 63010 Website ~20.99 miles northeast of Desoto
  • Low-priced Suburban hotel
  • Free breakfast
From£47
Average 3.0 /5 Hotel Reviews Call BookMore Details
Woodspring Suites St. Louis Arnold : 888 Arnold Commons Dr.
+1-888-841-5292
888 Arnold Commons Dr., Arnold, MO 63010 ~22.48 miles northeast of Desoto
  • Inexpensive Highway hotel
  • Hotel has 124 rooms
From£25
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Drury Inn & Suites St. Louis Arnold : 3800 State Rt 141
+1-888-455-5160
3800 State Rt 141, Arnold, MO 63010 ~22.60 miles northeast of Desoto
  • Midscale Suburban hotel
  • Hotel has 15 suites
From£97
Excellent 5.0 /5 Read Reviews Call BookMore Details
Pear Tree Inn St. Louis Arnold - Arnold
+1-888-965-8297
1201 Drury Lane, Arnold, MO 63010 ~23.18 miles northeast of Desoto
  • 3-star Suburban property
  • Check-in time: 3:00 PM
From£63
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Crown Pointe Lodge, BW Signature Collection in Farmington
+1-888-906-6358
4245 Hunt Rd., Farmington, MO 63640 ~23.30 miles south of Desoto
  • Affordable Golf Course property
  • 48 rooms in property
From£51
Very good 4.0 /5 Reviews Call BookMore Details
Best Western St. Louis Inn - Saint Louis
+1-888-749-6785
6224 Heimos Industrial Park Dr., Saint Louis, MO 63129 ~24.45 miles northeast of Desoto
  • Two-star Suburban hotel
  • Hotel has 87 rooms
From£32
Average 3.0 /5 Hotel Reviews Call BookMore Details
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Hampton Inn Farmington : 850 Valley Creek Dr.
+1-888-878-9982
850 Valley Creek Dr., Farmington, MO 63640 ~24.74 miles south of Desoto
  • 3 star Highway property
  • 64 sleeping rooms in hotel
From£63
Average 3.0 /5 Guest Reviews Call BookMore Details
Super 8 by Wyndham Farmington
+1-888-389-4485
930 Valley Creek Dr., Farmington, MO 63640 ~24.81 miles south of Desoto
  • 2 star property
  • Complimentary breakfast is offered
From£38
Average 3.0 /5 Review Score Call BookMore Details
Holiday Inn Express & Suites Farmington, an IHG Hotel : 820 Market St.
+1-888-389-4121
820 Market St., Farmington, MO 63640 ~24.84 miles south of Desoto
  • Midscale Rural hotel
  • 20 suites in hotel
From£78
Very good 4.0 /5 Guest Reviews Call BookMore Details
Quality Inn Farmington : 1400 West Liberty St.
+1-888-675-2083
1400 West Liberty St., Farmington, MO 63640 ~25.67 miles south of Desoto
  • 3-star Rural property
  • Hotel has 48 rooms
From£63
Average 3.0 /5 Review Score Call BookMore Details
America's Best Inn Eureka
+1-800-716-8490
1725 West 5th St., Eureka, MO 63025 ~25.91 miles north of Desoto
  • Low-priced Highway property
Super 8 by Wyndham Eureka/Six Flags Nearby : 1733 West 5th St.
+1-800-805-5223
1733 West 5th St., Eureka, MO 63025 ~25.97 miles north of Desoto
  • 2-star Highway property
  • Free complimentary breakfast
From£47
Average 3.0 /5 Reviews Call BookMore Details
Baymont Inn and Suites by Wyndham Farmington, MO
+1-888-965-1860
1625 West Columbia St., Farmington, MO 63640 ~26.01 miles south of Desoto
  • Affordable Highway property
  • 3 conference rooms in property
From£63
Average 3.0 /5 Reviews Call BookMore Details
Fairfield Inn N Ste St. Louis South - St Louis
+1-888-788-5576
4318 Butler Hill Rd., St Louis, MO 63128 ~26.12 miles northeast of Desoto
  • 3 star property
From£71
Average 3.0 /5 Read Reviews Call BookMore Details
Holiday Inn Express & Suites St. Louis South - I-55, an IHG Hotel
+1-888-897-9207
4250 Midamerica Ln, St. Louis, MO 63129 ~26.15 miles northeast of Desoto
  • Three Star Suburban hotel
  • Hotel has an eco-friendly policy Learn more
From£63
Average 3.0 /5 Guest Reviews Call BookMore Details
Quality Inn Near Six Flags St. Louis
+1-888-311-4278
1400 West Osage St., Pacific, MO 63069 ~26.20 miles northwest of Desoto
  • Mid-scale Rural property
  • 46 rooms in property
From£63
Very good 4.0 /5 Read Reviews Call BookMore Details
Hampton Inn & Suites St. Louis/South I-55
+1-888-469-4795
4200 Midamerica Ln, St. Louis, MO 63129 ~26.21 miles northeast of Desoto
  • Midscale Suburban property
  • 92 rooms in property
From£63
Very good 4.0 /5 Read Reviews Call BookMore Details
Comfort Inn Near Six Flags St. Louis
+1-888-734-9421
1320 Thornton St., Pacific, MO 63069 Website ~26.31 miles northwest of Desoto
  • 3 star Highway hotel
  • 70 rooms in hotel
From£70
Average 3.0 /5 Hotel Reviews Call BookMore Details
Holiday Inn St. Louis West Six Flags, an IHG Hotel - Eureka
+1-888-841-5292
4901 Six Flags Rd., Eureka, MO 63025 ~26.44 miles north of Desoto
  • Three Star Suburban property
  • Gym / Fitness Center Available
From£102
Average 3.0 /5 Recent Reviews Call BookMore Details
Super 8 by Wyndham Waterloo - Waterloo
+1-888-455-5160
112 Warren Dr., Waterloo, IL 62298 ~26.69 miles northeast of Desoto
  • Two-star Rural hotel
  • Check in time: 3:00 PM
From£47
Average 3.5 /5 Hotel Reviews Call BookMore Details
Super 8 by Wyndham St. Clair MO : 1010 South Outer Rd.
+1-888-965-8297
1010 South Outer Rd., Saint Clair, MO 63077 ~27.54 miles northwest of Desoto
  • 2 star Highway property
  • Free comp. breakfast
From£47
Average 3.0 /5 Read Reviews Call BookMore Details
Pinemark Inn & Suites in St. Clair
+1-888-906-6358
866 South Outer Rd., St. Clair, MO 63077 ~27.61 miles northwest of Desoto
  • 2-star Highway property
  • Free breakfast available
From£48
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Hampton Inn St. Louis Southwest
+1-888-749-6785
9 Lambert Drury Dr., St. Louis, MO 63088 ~27.69 miles north of Desoto
  • Three Star Suburban hotel
  • Complimentary breakfast is offered
From£59
Very good 4.5 /5 Guest Reviews Call BookMore Details
Drury Inn & Suites St. Louis Southwest - St. Louis
+1-888-878-9982
5 Lambert Drury Place (I 44 & 141), St. Louis, MO 63088 ~27.70 miles north of Desoto
  • 3-star Suburban hotel
  • 7 floors in hotel
From£66
Very good 4.5 /5 Recent Reviews Call BookMore Details
Hampton Inn St. Louis Columbia
+1-888-389-4485
165 Admiral Trost Dr., Columbia, IL 62236 ~27.77 miles northeast of Desoto
  • 3-star Suburban hotel
  • 2 meeting rooms in hotel
From£63
Average 3.0 /5 Guest Reviews Call BookMore Details
Holiday Inn Express St. Louis West Fenton
+1-888-389-4121
1848 Bowles Ave., Fenton, MO 63026 ~28.01 miles north of Desoto
  • Mid-scale Suburban property
  • Free breakfast available
From£63
Very good 4.0 /5 Guest Reviews Call BookMore Details
Motel 6 Fenton Mo
+1-888-675-2083
1860 Bowles Ave., Fenton, MO 63026 ~28.03 miles north of Desoto
  • Economy property
From£47
Average 3.0 /5 Guest Reviews Call BookMore Details
Wingate by Wyndham St. Louis / Fenton Route 66
+1-800-716-8490
1100 South Highway Dr., Fenton, MO 63026 ~28.15 miles north of Desoto
  • Midscale Suburban hotel
  • Hotel has a green policy See more
From£63
Average 3.0 /5 Review Score Call BookMore Details
Drury Inn & Suites St. Louis Fenton - Fenton
+1-800-805-5223
1088 South Highway Dr., Fenton, MO 63026 ~28.26 miles north of Desoto
  • Mid-scale Suburban property
  • Hotel has 137 rooms
From£74
Very good 4.0 /5 Recent Reviews Call BookMore Details
Extended Stay America Suites St. Louis Fenton in Fenton
+1-888-965-1860
1662 Fenton Business Park Court, Fenton, MO 63026 ~28.29 miles north of Desoto
  • 3 star Suburban hotel
  • 3 floors in hotel
From£63
Average 3.0 /5 Read Reviews Call BookMore Details
Americas Best Value Inn St. Louis South in St. Louis
+1-888-788-5576
6602 South Lindbergh Blvd., St. Louis, MO 63123 ~28.30 miles northeast of Desoto
  • Low-priced Suburban hotel
  • Complimentary breakfast is offered
Best Western Plus Fenton
+1-888-897-9207
1680 Fenton Business Park Court, Fenton, MO 63026 ~28.36 miles north of Desoto
  • Mid-scale Suburban property
  • Hotel has 3 floors
From£51
Average 3.0 /5 Review Score Call BookMore Details
Super 8 by Wyndham Fenton/St. Louis Area
+1-888-311-4278
650 South Highway Dr., Fenton, MO 63026 ~28.38 miles north of Desoto
  • Cheap hotel
  • Check-in: 15:00
Aviator Hotel & Suites South I 55 Best Western Signature Collecti
+1-888-469-4795
6921 South Lindbergh Blvd., St Louis, MO 63125 ~28.39 miles northeast of Desoto
  • Three Star Suburban property
  • Hotel has 4 floors
From£63
Average 3.0 /5 Review Score Call BookMore Details
Microtel Inn & Suites by Wyndham Sainte Genevieve
+1-888-734-9421
21958 Highway 32, Sainte Genevieve, MO 63670 ~29.61 miles east of Desoto
  • Inexpensive Highway property
  • Free comp. breakfast
From£59
Very good 4.0 /5 Recent Reviews Call BookMore Details
Days Inn by Wyndham St. Louis Lindbergh Boulevard : 3660 South Lindbergh Blvd.
+1-888-841-5292
3660 South Lindbergh Blvd., St Louis, MO 63127 ~29.65 miles north of Desoto
  • 3-star Suburban hotel
  • Free breakfast available
From£54
Average 3.0 /5 Latest Reviews Call BookMore Details
Holiday Inn St. Louis Sw Route 66 An Ihg Hotel
+1-888-455-5160
10709 Watson Rd., St. Louis, MO 63127 ~29.82 miles north of Desoto
  • Three Star Suburban property
  • 12 suites in hotel
From£62
Average 3.0 /5 Read Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham in Saint Louis
+1-888-965-8297
1580 South Kirkwood Rd., Saint Louis, MO 63127 ~29.89 miles north of Desoto
  • 3 star Suburban property
  • Complimentary breakfast is offered
From£79
Average 3.0 /5 Latest Reviews Call BookMore Details
Best Western St. Louis-Kirkwood Route 66
+1-888-906-6358
1200 South Kirkwood Rd., Saint Louis, MO 63122 ~30.33 miles north of Desoto
  • 3-star Suburban property
  • Free breakfast available
From£55
Very good 4.0 /5 Read Reviews Call BookMore Details
The Wildwood Hotel
+1-888-749-6785
2801 Fountain Place, Wildwood, MO 63040 ~30.80 miles north of Desoto
  • Four star Suburban hotel
  • 5 floors in property
From£79
Very good 4.0 /5 Reviews Call BookMore Details
Super 8 by Wyndham Union - Union
+1-888-878-9982
1015 East Main St., Union, MO 63084 ~31.93 miles northwest of Desoto
  • Economy Rural hotel
  • Check in: 11:00 AM
From£53
Average 3.0 /5 Read Reviews Call BookMore Details

Next: See My Desoto Hotels with Pricing

Graph: Upcoming 20 Days of Desoto Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Desoto, MO discounts available. The chart reflects the cheapest Desoto hotel for each day and each star rating category.

FAQs about hotels in Desoto

What are the top reviewed hotels in Desoto?

Drury Inn & Suites St. Louis Arnold, Holiday Inn Club Vac Timber Creek and Hampton Inn St. Louis Southwest are the best rated hotels based on customer reviews in the last 365 days.

What are the most high-end hotels in Desoto?

The Wildwood Hotel, Holiday Inn Club Vac Timber Creek and Comfort Inn Festus - St Louis South are the top 3 luxury hotels near Desoto city center.

What hotels are closest to the city center of Desoto?

Holiday Inn Club Vac Timber Creek, Holiday Inn Express Hotel & Suites Festus South St. Louis An I, and Comfort Inn Festus - St Louis South are the properties closest to Desoto city center.

What are the most popular independent hotels in Desoto?

Pinemark Inn & Suites, The Wildwood Hotel and America's Best Inn Eureka are the best rated independent hotels (not part of a big brand).

What are the most popular Choice Hotels branded hotels in Desoto?

Comfort Inn Festus - St Louis South, Woodspring Suites St. Louis Arnold and Quality Inn Near Six Flags St. Louis are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the most popular Best Western hotels in Desoto?

Crown Pointe Lodge, BW Signature Collection, Best Western St. Louis-Kirkwood Route 66 and Best Western St. Louis Inn are the best rated Best Western branded hotels (based on user reviews score).

What are the most popular IHG hotels in Desoto?

Holiday Inn Club Vac Timber Creek, Holiday Inn Express Hotel & Suites Festus South St. Louis An I and Holiday Inn Express & Suites Farmington, an IHG Hotel are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

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