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Desoto Missouri Accommodations

Find hotels in Desoto using the list and search tools below. Search for the cheapest discounted hotel and motel rates in or near Desoto, MO for your corporate or personal leisure travel. We show the best Desoto Missouri hotel rooms. Review the Desoto hotel list below to find the perfect lodging. We also have a map of the Desoto hotels.

Desoto Hotels, Motels & Accommodations

Holiday Inn Club Vac Timber Creek - Desoto
+1-888-389-4121
4800 Us Highway 67, Desoto, MO 63020
  • Three Star property
  • Hotel has 3 floors
From£72
Very good 4.5 /5 Hotel Reviews Call BookMore Details
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Holiday Inn Express Hotel & Suites Festus South St. Louis An I in Festus
+1-888-675-2083
1802 Gamel Cemetery Rd., Festus, MO 63028 ~9.29 miles northeast of Desoto
  • Two star Highway property
  • Fitness + Health Center
From£72
Very good 4.0 /5 Latest Reviews Call BookMore Details
Comfort Inn Festus - St Louis South : 1303 Veterans Blvd.
+1-800-716-8490
1303 Veterans Blvd., Festus, MO 63028 Website ~9.49 miles northeast of Desoto
  • 3 star Suburban hotel
  • Hotel has 89 rooms
From£36
Very good 4.0 /5 Latest Reviews Call BookMore Details
Quality Inn Festus : 1200 West Gannon Dr.
+1-800-805-5223
1200 West Gannon Dr., Festus, MO 63028 Website ~9.52 miles northeast of Desoto
  • 3-star Suburban property
  • Free breakfast available
From£58
Average 3.0 /5 Recent Reviews Call BookMore Details
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
+1-888-965-1860
1001 Veterans Blvd., Festus, MO 63028 ~9.71 miles northeast of Desoto
  • 3-star Suburban hotel
  • Check-in time: 3:00 PM
From£64
Average 3.0 /5 Guest Reviews Call BookMore Details
Super 8 by Wyndham Pevely
+1-888-788-5576
1711 Highway Z, Pevely, MO 63070 ~13.04 miles northeast of Desoto
  • Economy property
  • Check-in time: 11:00 AM
From£28
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Super 8 by Wyndham Bonne Terre in Bonne Terre
+1-888-897-9207
8 Northwood Dr., Bonne Terre, MO 63628 ~14.95 miles south of Desoto
  • Low-priced hotel
From£48
Average 3.0 /5 Hotel Reviews Call BookMore Details
Motel 6 Bonne Terre Mo in Bonne Terre
+1-888-311-4278
1017 Highway K, Bonne Terre, MO 63628 ~15.14 miles south of Desoto
  • Low Cost property
From£48
Average 3.0 /5 Recent Reviews Call BookMore Details
Super 8 by Wyndham Potosi
+1-888-469-4795
820 East High St., Potosi, MO 63664 ~18.93 miles southwest of Desoto
  • Low-priced Highway property
  • Hotel has 2 floors
From£39
Average 3.0 /5 Guest Reviews Call BookMore Details
Quality Inn & Suites
+1-888-734-9421
3610 West Outer Rd., Arnold, MO 63010 Website ~20.99 miles northeast of Desoto
  • Low Cost Suburban hotel
  • Comp. Breakfast
From£48
Average 3.0 /5 Recent Reviews Call BookMore Details
Woodspring Suites St. Louis Arnold
+1-888-841-5292
888 Arnold Commons Dr., Arnold, MO 63010 ~22.48 miles northeast of Desoto
  • Inexpensive Highway hotel
  • Check in time: 3 p.m.
From£25
Very good 4.0 /5 Recent Reviews Call BookMore Details
Drury Inn & Suites St. Louis Arnold : 3800 State Rt 141
+1-888-455-5160
3800 State Rt 141, Arnold, MO 63010 ~22.60 miles northeast of Desoto
  • Midscale Suburban property
  • Free breakfast available
From£99
Excellent 5.0 /5 Guest Reviews Call BookMore Details
Pear Tree Inn St. Louis Arnold in Arnold
+1-888-965-8297
1201 Drury Lane, Arnold, MO 63010 ~23.18 miles northeast of Desoto
  • 3-star Suburban hotel
  • 96 sleeping rooms in hotel
From£64
Very good 4.0 /5 Read Reviews Call BookMore Details
Crown Pointe Lodge, BW Signature Collection
+1-888-906-6358
4245 Hunt Rd., Farmington, MO 63640 ~23.30 miles south of Desoto
  • Mid-scale Golf Course property
  • Hotel has 17 suites
From£51
Very good 4.0 /5 Guest Reviews Call BookMore Details
Best Western St. Louis Inn
+1-888-749-6785
6224 Heimos Industrial Park Dr., Saint Louis, MO 63129 ~24.45 miles northeast of Desoto
  • Economical Suburban property
  • Complimentary breakfast is offered
From£33
Average 3.0 /5 Recent Reviews Call BookMore Details
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Hampton Inn Farmington : 850 Valley Creek Dr.
+1-888-878-9982
850 Valley Creek Dr., Farmington, MO 63640 ~24.74 miles south of Desoto
  • 3-star Highway hotel
  • 3 floors in property
From£64
Average 3.0 /5 Guest Reviews Call BookMore Details
Super 8 by Wyndham Farmington in Farmington
+1-888-389-4485
930 Valley Creek Dr., Farmington, MO 63640 ~24.81 miles south of Desoto
  • Economy property
  • 60 rooms in hotel
From£39
Average 3.0 /5 Review Score Call BookMore Details
Holiday Inn Express & Suites Farmington, an IHG Hotel - Farmington
+1-888-389-4121
820 Market St., Farmington, MO 63640 ~24.84 miles south of Desoto
  • Midscale Rural property
  • Check-in time: 3:00pm
From£80
Very good 4.0 /5 Latest Reviews Call BookMore Details
Quality Inn Farmington
+1-888-675-2083
1400 West Liberty St., Farmington, MO 63640 ~25.67 miles south of Desoto
  • 3-star Rural hotel
  • 48 rooms in hotel
From£64
Average 3.0 /5 Latest Reviews Call BookMore Details
America's Best Inn Eureka - Eureka
+1-800-716-8490
1725 West 5th St., Eureka, MO 63025 ~25.91 miles north of Desoto
  • Inexpensive Highway property
  • Check in: 11.00am
Super 8 by Wyndham Eureka/Six Flags Nearby : 1733 West 5th St.
+1-800-805-5223
1733 West 5th St., Eureka, MO 63025 ~25.97 miles north of Desoto
  • Low-priced Highway property
  • Check in time: ex. 3:00 PM
From£48
Average 3.0 /5 Read Reviews Call BookMore Details
Baymont Inn and Suites by Wyndham Farmington, MO
+1-888-965-1860
1625 West Columbia St., Farmington, MO 63640 ~26.01 miles south of Desoto
  • Midscale Highway hotel
  • Complimentary breakfast is offered
From£64
Average 3.0 /5 Guest Reviews Call BookMore Details
Fairfield Inn N Ste St. Louis South
+1-888-788-5576
4318 Butler Hill Rd., St Louis, MO 63128 ~26.12 miles northeast of Desoto
  • Mid-scale property
  • Check-in: 15:00
From£72
Average 3.0 /5 Latest Reviews Call BookMore Details
Holiday Inn Express & Suites St. Louis South - I-55, an IHG Hotel : 4250 Midamerica Ln
+1-888-897-9207
4250 Midamerica Ln, St. Louis, MO 63129 ~26.15 miles northeast of Desoto
  • Mid-scale Suburban hotel
  • Hotel has 17 suites
From£64
Average 3.0 /5 Guest Reviews Call BookMore Details
Quality Inn Near Six Flags St. Louis
+1-888-311-4278
1400 West Osage St., Pacific, MO 63069 ~26.20 miles northwest of Desoto
  • 3 star Rural hotel
  • Hotel has 46 rooms
From£64
Very good 4.0 /5 Guest Reviews Call BookMore Details
Hampton Inn & Suites St. Louis/South I-55 - St. Louis
+1-888-469-4795
4200 Midamerica Ln, St. Louis, MO 63129 ~26.21 miles northeast of Desoto
  • Affordable Suburban property
  • 4 floors in hotel
From£64
Very good 4.0 /5 Guest Reviews Call BookMore Details
Comfort Inn Near Six Flags St. Louis : 1320 Thornton St.
+1-888-734-9421
1320 Thornton St., Pacific, MO 63069 Website ~26.31 miles northwest of Desoto
  • Mid-scale Highway property
  • Hotel has 70 rooms
From£71
Average 3.0 /5 Latest Reviews Call BookMore Details
Holiday Inn St. Louis West Six Flags, an IHG Hotel - Eureka
+1-888-841-5292
4901 Six Flags Rd., Eureka, MO 63025 ~26.44 miles north of Desoto
  • 3-star Suburban property
  • Hotel has 3 floors
From£104
Average 3.0 /5 Read Reviews Call BookMore Details
Super 8 by Wyndham Waterloo : 112 Warren Dr.
+1-888-455-5160
112 Warren Dr., Waterloo, IL 62298 ~26.69 miles northeast of Desoto
  • Inexpensive Rural property
  • Free breakfast
From£48
Average 3.5 /5 Guest Reviews Call BookMore Details
Super 8 by Wyndham St. Clair MO
+1-888-965-8297
1010 South Outer Rd., Saint Clair, MO 63077 ~27.54 miles northwest of Desoto
  • Inexpensive Highway property
  • 3 floors in hotel
From£48
Average 3.0 /5 Hotel Reviews Call BookMore Details
Pinemark Inn & Suites - St. Clair
+1-888-906-6358
866 South Outer Rd., St. Clair, MO 63077 ~27.61 miles northwest of Desoto
  • Two-star Highway property
  • 3 suites in property
From£49
Very good 4.0 /5 Review Score Call BookMore Details
Hampton Inn St. Louis Southwest in St. Louis
+1-888-749-6785
9 Lambert Drury Dr., St. Louis, MO 63088 ~27.69 miles north of Desoto
  • Midscale Suburban hotel
  • 4 floors in hotel
From£60
Very good 4.5 /5 Read Reviews Call BookMore Details
Drury Inn & Suites St. Louis Southwest
+1-888-878-9982
5 Lambert Drury Place (I 44 & 141), St. Louis, MO 63088 ~27.70 miles north of Desoto
  • Affordable Suburban property
  • Fitness / Gym is on-site
From£67
Very good 4.5 /5 Read Reviews Call BookMore Details
Hampton Inn St. Louis Columbia in Columbia
+1-888-389-4485
165 Admiral Trost Dr., Columbia, IL 62236 ~27.77 miles northeast of Desoto
  • 3 star Suburban hotel
  • Hotel has 3 floors
From£64
Average 3.0 /5 Recent Reviews Call BookMore Details
Holiday Inn Express St. Louis West Fenton : 1848 Bowles Ave.
+1-888-389-4121
1848 Bowles Ave., Fenton, MO 63026 ~28.01 miles north of Desoto
  • Affordable Suburban hotel
  • 3 floors in hotel
From£64
Very good 4.0 /5 Read Reviews Call BookMore Details
Motel 6 Fenton Mo - Fenton
+1-888-675-2083
1860 Bowles Ave., Fenton, MO 63026 ~28.03 miles north of Desoto
  • Economical hotel
From£48
Average 3.0 /5 Review Score Call BookMore Details
Wingate by Wyndham St. Louis / Fenton Route 66 in Fenton
+1-800-716-8490
1100 South Highway Dr., Fenton, MO 63026 ~28.15 miles north of Desoto
  • Mid-scale Suburban hotel
  • Fitness center on property
From£64
Average 3.0 /5 Reviews Call BookMore Details
Heritage Inn & Suites St. Louis / Fenton Trademark by Wyndham - Fenton
+1-800-805-5223
1088 South Highway Dr., Fenton, MO 63026 ~28.20 miles north of Desoto
  • Midscale Suburban hotel
  • 4 floors in property
From£64
Average 3.0 /5 Reviews Call BookMore Details
Extended Stay America Suites St. Louis Fenton
+1-888-965-1860
1662 Fenton Business Park Court, Fenton, MO 63026 ~28.29 miles north of Desoto
  • Affordable Suburban hotel
  • Free complimentary breakfast
From£64
Average 3.0 /5 Read Reviews Call BookMore Details
Americas Best Value Inn St. Louis South : 6602 South Lindbergh Blvd.
+1-888-788-5576
6602 South Lindbergh Blvd., St. Louis, MO 63123 ~28.30 miles northeast of Desoto
  • Low priced Suburban hotel
  • Hotel has 3 floors
From£39
Poor 2.0 /5 Read Reviews Call BookMore Details
Best Western Plus Fenton
+1-888-897-9207
1680 Fenton Business Park Court, Fenton, MO 63026 ~28.36 miles north of Desoto
  • Midscale Suburban property
  • 102 rooms in hotel
From£64
Average 3.0 /5 Recent Reviews Call BookMore Details
Super 8 by Wyndham Fenton/St. Louis Area : 650 South Highway Dr.
+1-888-311-4278
650 South Highway Dr., Fenton, MO 63026 ~28.38 miles north of Desoto
  • 2 star hotel
Aviator Hotel & Suites South I 55 Best Western Signature Collecti : 6921 South Lindbergh Blvd.
+1-888-469-4795
6921 South Lindbergh Blvd., St Louis, MO 63125 ~28.39 miles northeast of Desoto
  • 3-star Suburban hotel
  • Access to gym on-site
From£64
Average 3.0 /5 Hotel Reviews Call BookMore Details
Microtel Inn & Suites by Wyndham Sainte Genevieve : 21958 Highway 32
+1-888-734-9421
21958 Highway 32, Sainte Genevieve, MO 63670 ~29.61 miles east of Desoto
  • 2 star Highway hotel
  • Free breakfast available
From£60
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Days Inn by Wyndham St. Louis Lindbergh Boulevard - St Louis
+1-888-841-5292
3660 South Lindbergh Blvd., St Louis, MO 63127 ~29.65 miles north of Desoto
  • 3 star Suburban property
  • Hotel has 2 floors
From£55
Average 3.0 /5 Reviews Call BookMore Details
Holiday Inn St. Louis Sw Route 66 An Ihg Hotel
+1-888-455-5160
10709 Watson Rd., St. Louis, MO 63127 ~29.82 miles north of Desoto
  • Midscale Suburban hotel
  • 213 rooms in hotel
From£63
Average 3.0 /5 Review Score Call BookMore Details
La Quinta Inn & Suites by Wyndham
+1-888-965-8297
1580 South Kirkwood Rd., Saint Louis, MO 63127 ~29.89 miles north of Desoto
  • Midscale Suburban property
  • Check in time: 3:00PM
From£80
Average 3.0 /5 Read Reviews Call BookMore Details
Best Western St. Louis-Kirkwood Route 66 in Saint Louis
+1-888-906-6358
1200 South Kirkwood Rd., Saint Louis, MO 63122 ~30.33 miles north of Desoto
  • Three Star Suburban hotel
  • Comp. Breakfast
From£56
Very good 4.0 /5 Hotel Reviews Call BookMore Details
The Wildwood Hotel in Wildwood
+1-888-749-6785
2801 Fountain Place, Wildwood, MO 63040 ~30.80 miles north of Desoto
  • 4-star Suburban hotel
  • Check in: 04:00 PM
From£80
Very good 4.0 /5 Hotel Reviews Call BookMore Details
Super 8 by Wyndham Union - Union
+1-888-878-9982
1015 East Main St., Union, MO 63084 ~31.93 miles northwest of Desoto
  • Low priced Rural property
  • Comp. Breakfast
From£54
Average 3.0 /5 Review Score Call BookMore Details

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Graph: Upcoming 20 Days of Desoto Hotel Rates

Rates shown are nightly rates before taxes and do not necessarily reflect all Desoto, MO discounts available. The chart reflects the cheapest Desoto hotel for each day and each star rating category.

FAQs about hotels in Desoto

What are the top reviewed hotels in Desoto?

Drury Inn & Suites St. Louis Arnold, Holiday Inn Club Vac Timber Creek and Hampton Inn St. Louis Southwest are the best rated hotels based on customer reviews in the last 365 days.

What are the most high-end hotels in Desoto?

The Wildwood Hotel, Holiday Inn Club Vac Timber Creek and Comfort Inn Festus - St Louis South are the top 3 luxury hotels near Desoto city center.

What hotels are closest to the city center of Desoto?

Holiday Inn Club Vac Timber Creek, Holiday Inn Express Hotel & Suites Festus South St. Louis An I, and Comfort Inn Festus - St Louis South are the properties closest to Desoto city center.

What are the most popular independent hotels in Desoto?

Pinemark Inn & Suites, The Wildwood Hotel and America's Best Inn Eureka are the best rated independent hotels (not part of a big brand).

What are the most popular Choice Hotels branded hotels in Desoto?

Comfort Inn Festus - St Louis South, Woodspring Suites St. Louis Arnold and Quality Inn Near Six Flags St. Louis are the best rated Choice Hotels branded hotels (based on HotelPlanner reviews score).

What are the most popular Best Western hotels in Desoto?

Crown Pointe Lodge, BW Signature Collection, Best Western St. Louis-Kirkwood Route 66 and Best Western St. Louis Inn are the best rated Best Western branded hotels (based on user reviews score).

What are the most popular IHG hotels in Desoto?

Holiday Inn Club Vac Timber Creek, Holiday Inn Express Hotel & Suites Festus South St. Louis An I and Holiday Inn Express & Suites Farmington, an IHG Hotel are the best rated Intercontinental Hotel Group (IHG) branded hotels (based on user reviews score).

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